New Insights on Tramadol and Immunomodulation

Saeed, Iqira; Caze, Adam La; Hollmann, Markus W.; Shaw, Paul N.; Parat, Marie-Odile

doi:10.1007/s11912-021-01121-y

Cited by 9 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 32 The immunomodulatory effects of Tramadol are primarily attributed to the activation of central monoamine neurotransmitters through the regulated inhibition of serotonin and norepinephrine reuptake by central neurons. 33 Lipid-soluble inhalation anesthetics, namely halothane, isoflurane, and sevoflurane, have been observed to impact the membrane structure of polymorphonuclear leukocytes (PMNs), resulting in a reduction of their functionality. This effect is attributed to the weakening of the expression of the adhesion molecule CD11b and the inhibition of PMN adhesion to endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of Anesthetic Drugs’ Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives

Wang,

Sun,

et al. 2023

DDDT

View full text Add to dashboard Cite

The objective of this study is to conduct a bibliometric analysis of the present status, areas of focus, and upcoming developments in the research of anesthetic drugs and their impact on immune function, along with other related research domains. Methods: From January 1, 2008 to June 9, 2023, A thorough exploration of anesthetic drug-related literature pertaining to immune function was carried out through the utilization of the Web of Science. The bibliometric analysis was predominantly executed by means of CiteSpace, GraphPad Prism 8.0, and the acquisition of data regarding the country, institution, author, journal, and keywords associated with each publication. Results: This study analyzed a comprehensive total of 318 publications, consisting of 228 articles and 90 reviews, to determine the publication output of anesthetic drugs on immune function. Notably, China exhibited the highest publication output with (109, 34.28%) articles. Among the institutions analyzed, Harvard University was found to be the most productive with (12, 3.77%) publications. The study findings indicate that Buggy, Donal J (5, 1.57%) and Yuki, Koichi (5, 1.57%) had the highest publication records. Anesthesiology was the most frequently cited journal with a total of (206) citations. The results also revealed that "surgery" was the most frequently used keyword, appearing (48 times), followed by "general anesthesia" (41 times) and "breast cancer" (37 times). The study has identified several current areas of interest, with a particular emphasis on "metastasis", "inflammation", "recurrence", "anesthesia technique", and "induction". It is anticipated that forthcoming research endeavors will concentrate on exploring the impacts of isoflurane, sevoflurane, and ketamine on immune function. Conclusion:This study provided a thorough analysis of the research trends and developments in investigating the impact of anesthetic drugs on immune function, incorporating pertinent research and collaborative entities such as authors, institutions, and countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of Anesthetic Drugs’ Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives

Wang,

Sun,

et al. 2023

DDDT

View full text Add to dashboard Cite

show abstract

“…The immunomodulatory effects of tramadol have previously been shown to cause immunoenhancement via significantly enhanced NK cell activity and IL-2 production when administered acutely, but with ongoing chronic administration these immune effects disappeared (131). In other studies, the use of tramadol has been shown to preserve, but not stimulate, immune function when compared to other opioids such as morphine (132). This includes in vitro studies showing that morphine decreased monocyte phagocytosis but tramadol did not (133); morphine, methadone, and oxycodone inhibited IL-6 production but tramadol did not (134); that NK cell count decreases were less pronounced in gastric patients administered tramadol compared to morphine (135); and that tramadol administration reduced localized oedema and hyperalgesia without affecting immune mechanisms (136).…”

Section: Opioidsmentioning

confidence: 97%

The impact of stress and anesthesia on animal models of infectious disease

Layton

Beggs

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Stress and general anesthesia have an impact on the functional response of the organism due to the detrimental effects on cardiovascular, immunological, and metabolic function, which could limit the organism's response to an infectious event. Animal studies have formed an essential step in understanding and mitigating infectious diseases, as the complexities of physiology and immunity cannot yet be replicated in vivo. Using animals in research continues to come under increasing societal scrutiny, and it is therefore crucial that the welfare of animals used in disease research is optimized to meet both societal expectations and improve scientific outcomes. Everyday management and procedures in animal studies are known to cause stress, which can not only cause poorer welfare outcomes, but also introduces variables in disease studies. Whilst general anesthesia is necessary at times to reduce stress and enhance animal welfare in disease research, evidence of physiological and immunological disruption caused by general anesthesia is increasing. To better understand and quantify the effects of stress and anesthesia on disease study and welfare outcomes, utilizing the most appropriate animal monitoring strategies is imperative. This article aims to analyze recent scientific evidence about the impact of stress and anesthesia as uncontrolled variables, as well as reviewing monitoring strategies and technologies in animal models during infectious diseases.

show abstract

“…It does not inhibit the immune system like other opioids. 57 Unfortunately, tramadol is rarely used in oncology due to its weak analgesic effect and unpleasant side effects at higher doses.…”

Section: Pathophysiology Of Metastasismentioning

confidence: 99%

The influence of anaesthesia on cancer growth

Potocnik,

Kerin-Povsic,

Markovic-Bozic

2024

Radiology and Oncology

View full text Add to dashboard Cite

Background Oncological patients make up a large proportion of all surgical patients. Through its influence on the patient’s inflammatory and immune system, the choice of anaesthetic technique has an indirect impact on the health of the individual patient and on public health. Both the specific and the non-specific immune system have a major influence on the recurrence of carcinomas. The pathophysiological basis for growth and metastasis after surgery is the physiological response to stress. Inflammation is the organism’s universal response to stress. Anaesthetics and adjuvants influence perioperative inflammation in different ways and have an indirect effect on tumour growth and metastasis. In vitro studies have shown how individual anaesthetics influence the growth and spread of cancer, but clinical studies have not confirmed these results. Nevertheless, it is advisable to use an anaesthetic that has shown lesser effect on the growth of cancer cells in vitro. Conclusions In this review, we focus on the area of the effects of anaesthesia on tumour growth. The field is still relatively unexplored, there are only few clinical prospective studies and their results are controversial. Based on the review of new research findings we report on recommendations about anaesthetics and anaesthetic techniques that might be preferable for oncological surgical procedures.

show abstract

New Insights on Tramadol and Immunomodulation

Cited by 9 publications

References 48 publications

Bibliometric Analysis of Anesthetic Drugs’ Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives

Bibliometric Analysis of Anesthetic Drugs’ Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives

The impact of stress and anesthesia on animal models of infectious disease

The influence of anaesthesia on cancer growth

Contact Info

Product

Resources

About