New insights on the structure of hexagonally faceted platelets from hydrophobically modified chitosan and α-cyclodextrin

Ahmed, Zeeshan; Malli, Sophia; Diaz-Salmeron, Raul; Destruel, Pierre-Louis; Costa, Antonio Da; Porcher, Florence; Ponchel, Gilles; Bouchemal, Kawthar

doi:10.1016/j.ijpharm.2018.06.035

Cited by 10 publications

(3 citation statements)

References 32 publications

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“…[56] Ahmed et al also reported that chitosan modified with various types of alkyl chains formed elastic dome-shaped particles. [57] These results further confirmed the aggregation tendency of polysaccharide chains with anionic groups, and corresponding changes of molecular morphology were observed following the selenylation of GG. Based on the results, Se-GG 3 might provide more negatively charged groups, which enhanced the inter-and intra-molecular interactions among polysaccharide molecules.…”

Section: Atomic Force Microscopy (Afm)supporting

confidence: 75%

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Selenylation of Guar Gum Mediated by N‐Methyl‐2‐pyrrolidone Hydrosulfate: Insights into Regulation of Selenium Content and Molecular Weight

Zhou

et al. 2022

ChemistrySelect

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Selenylation is an important modification strategy of polysaccharide, however, one of the main obstacles is that the weak esterification ability of selenide reagent, which leads to the low Se conversion efficiency during reaction. Here, we used N-methyl-2-pyrrolidone hydrosulfate ([HNMP]HSO 4 ) as acid catalyst efficiently synthesized selenized guar gum (Se-GGs) to improve the activity of selenide reagent. The chemical structure of GG and selenized derivatives was investigated using FT-IR, 1D/2D NMR spectrometry and atomic force microscopy (AFM).The results indicated that selenite groups existed in Se-GGs and the substitution position was at C6. Furthermore, it was also demonstrated that [HNMP]HSO 4 had a dual influence on GG by increasing the Se content (from 181.3 to 9072.8 μg/g) and regulating the molecular weight, which was due to strong Brönsted acidic proton (H + ). These results illustrated a new synthetic method for preparing functional polysaccharides with a broad range of potential applications.

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Section: Atomic Force Microscopy (Afm)supporting

confidence: 75%

“…Ahmed et al. also reported that chitosan modified with various types of alkyl chains formed elastic dome‐shaped particles [57] . These results further confirmed the aggregation tendency of polysaccharide chains with anionic groups, and corresponding changes of molecular morphology were observed following the selenylation of GG.…”

Section: Resultsmentioning

confidence: 60%

Selenylation of Guar Gum Mediated by N‐Methyl‐2‐pyrrolidone Hydrosulfate: Insights into Regulation of Selenium Content and Molecular Weight

Zhou

et al. 2022

ChemistrySelect

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“…[17] The NPs were formed by supramolecular and hierarchical self-assembly in water of HA hydrophobically modified with palmitic acid (HA-PA) and α-cyclodextrin. [18] In this investigation, the bioadhesion behaviors of NPs were evaluated ex vivo and in vivo in rats after intravesical instillation. The results were compared to nanospheres (NSs) with a comparable surface composition and surface potential.…”

Section: Introductionmentioning

confidence: 99%

Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder

Diaz-Salmeron

Toussaint

Cailleau

et al. 2022

Advanced NanoBiomed Research

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Intravesical instillation allows for direct exposure of the urothelium to a drug. However, the therapeutic efficacy is often limited by the rapid elimination of the drug from the bladder. In this investigation, it is hypothesized that the morphology of nanoparticulate drug delivery systems could significantly impact bioadhesion and bioelimination from the bladder. Bioadhesion kinetics evaluated ex vivo on rat bladder mucosa demonstrates that particles with a flattened morphology, denoted as nanoplatelets, are rapidly attached to the mucosa at a lower concentration than nanospheres. The two particles have comparable surface potentials and equivalent volumes and are composed of hyaluronan, a nonsulfated polysaccharide that plays a significant role in restoring the bladder glycosaminoglycan layer. The bioaccumulation and bioelimination studied in vivo reveal that the nanoplatelets are eliminated from the rat bladders less rapidly than nanospheres. This investigation suggests that the bioadhesion of HA could be improved by optimizing particle morphology, opening new opportunities for the treatment of local urothelial diseases, such as interstitial cystitis/painful bladder syndrome, by restoring the loss of the glycosaminoglycan layer.

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A Review: Uses of Chitosan in Pharmaceutical Forms

Frenț

Vicaş

Jurca

et al. 2021

Reviews of Physiology, Biochemistry and Pharmacology

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New insights on the structure of hexagonally faceted platelets from hydrophobically modified chitosan and α-cyclodextrin

Cited by 10 publications

References 32 publications

Selenylation of Guar Gum Mediated by N‐Methyl‐2‐pyrrolidone Hydrosulfate: Insights into Regulation of Selenium Content and Molecular Weight

Selenylation of Guar Gum Mediated by N‐Methyl‐2‐pyrrolidone Hydrosulfate: Insights into Regulation of Selenium Content and Molecular Weight

Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder

A Review: Uses of Chitosan in Pharmaceutical Forms

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