New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease

Martins, Airton C.; Morcillo, Patricia; Ijomone, Omamuyovwi M.; Venkataramani, Vivek; Harrison, Fiona E.; Lee, Eun-Sook; Bowman, Aaron B.; Aschner, Michael

doi:10.3390/ijerph16193546

Cited by 60 publications

(31 citation statements)

References 154 publications

(181 reference statements)

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“…Alzheimer's disease(AD), the clinical features of which include memory impairment, agnosia, visual-spatial skill impairment, executive dysfunction, and personality and behavioural changes, is the most important neurodegenerative disease [82]. The neuropathological features of AD include mainly neuronal and synaptic damage [83].…”

Section: Roles Of the Pi3k/akt/mtor Signalling Pathway In Neurodegenementioning

confidence: 99%

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RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

et al. 2020

Cell Biosci

434

263

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The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with those of other signalling pathways, the components of the PI3K/AKT/mTOR signalling pathway are complicated. The regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway are important in many human diseases, including ischaemic brain injury, neurodegenerative diseases, and tumours. PI3K/AKT/mTOR signalling pathway inhibitors include single-component and dual inhibitors. Numerous PI3K inhibitors have exhibited good results in preclinical studies, and some have been clinically tested in haematologic malignancies and solid tumours. In this review, we briefly summarize the results of research on the PI3K/AKT/mTOR pathway and discuss the structural composition, activation, communication processes, regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway in the pathogenesis of neurodegenerative diseases and tumours.

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Section: Roles Of the Pi3k/akt/mtor Signalling Pathway In Neurodegenementioning

confidence: 99%

“…Parkinson's disease (PD), one of the most common neurodegenerative diseases, involves many motor symptoms (such as quiescent tremors, rigidity, and postural instability) and nonmotor symptoms (such as autonomic nervous, mental, sensory, and cognitive impairments) [82].…”

Section: Progress In Understanding the Role Of Pi3k/akt/mtor In Pdmentioning

confidence: 99%

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

et al. 2020

Cell Biosci

434

263

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“…AD is a neurodegenerative disease positively concerned with age and associated with memory, cognitive impairment and behavioral changes ( Martins et al, 2019 ). Two chiefly pathological features as following: senile plaque (SP) with amyloid protein (Aβ) as the core and abnormal high phosphorylation of Tau protein in brain nerve cells to form neurofibrillary tangles (NFT).…”

Section: Roles Of Pi3k/akt Pathway In Alzheimer’s Diseasementioning

confidence: 99%

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

et al. 2021

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Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.

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“…It also plays an important role in the process of body growth and reproduction processes and stabilises blood sugar levels. Chronic manganese deficiency may lead to bone deformation, stunted growth, motor coordination disorders, diabetes or even schizophrenia, toxicity and neurological disorders [ 26 , 28 , 55 ]. Such a high level of manganese in tea does not seem to pose the risk of its excessive consumption, provided that the amount of tea infusions consumed daily does not significantly exceed one litre.…”

Section: Resultsmentioning

confidence: 99%

Tea as a Source of Biologically Active Compounds in the Human Diet

et al. 2021

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Due to the different levels of bioactive compounds in tea reported in the literature, the aim of this study was to determine whether commercially available leaf teas could be an important source of phenolics and selected minerals (copper, manganese, iron, zinc, magnesium, calcium, sodium, potassium) and if the differences in the content of these components between various types of tea are significant. It was found that both the amount of these compounds in tea and the antioxidant activity of tea infusions were largely determined by the origin of tea leaves as well as the processing method, which can modify the content of the studied components up to several hundred-fold. The group of green teas was the best source of phenolic compounds (110.73 mg/100 mL) and magnesium (1885 µg/100 mL) and was also characterised by the highest antioxidant activity (59.02%). This type of tea is a great contributor to the daily intake of the studied components. The average consumption of green tea infusions, assumed to be 3–4 cups (1 L) a day, provides the body with health-promoting polyphenol levels significantly exceeding the recommended daily dose. Moreover, drinking one litre of an unfermented tea infusion provides more than three times the recommended daily intake of manganese. Tea infusions can be a fairly adequate, but only a supplementary, source of potassium, zinc, magnesium, and copper in the diet. Moreover, it could be concluded that the antioxidant activity of all the analysed types of tea infusions results not only from the high content of phenolic compounds and manganese but is also related to the presence of magnesium and potassium.

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New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease

Cited by 60 publications

References 154 publications

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Tea as a Source of Biologically Active Compounds in the Human Diet

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