New insights on the role of autophagy in the pathogenesis and treatment of melanoma

Rahmati, Mohammad; Ebrahim, Shiva; Hashemi, S. Behnam; Motamedi, Marjan; Moosavi, Mohammad Amin

doi:10.1007/s11033-020-05886-6

Cited by 23 publications

(18 citation statements)

References 93 publications

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“…It is natural to question how these findings relate to the role of autophagy in human melanoma. Like in many cancers, autophagy is considered tumour suppressive in the transition from benign to malignant disease, but conversely tumour promoting in established melanoma [15,16]. Our data support a tumour preventive role in the early stages of melanoma development, and as mentioned above, a previous study has shown that ATG5 is down-regulated at this stage of human melanoma resulting in enhanced proliferation and bypass of senescence [9].…”

supporting

confidence: 87%

Loss of autophagy affects melanoma development in a manner dependent on PTEN status

et al. 2021

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supporting

confidence: 87%

Loss of autophagy affects melanoma development in a manner dependent on PTEN status

et al. 2021

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“…The isoxazole [4,5-e] [1,2,4] triazepine derivatives were tested on six tumor cell lines. The best compound was 6-acetyl-8-phenyl-5-(propan-2-yl)-5,6-dihydro-4H [1,2] oxazolo [4,5-e] [1,2,4]-triazepine-3-carboxamide. At a dose of 10 µmol, it inhibited the growth of colon cancer cells (Colo-205, HCC-2988 and HT-29), CNS tumor cells (9F-296 and SF-539), melanoma cells (M-14, MDA-MB-435 and SK -ME), ovarian cancer cells (NCJ/ADR-RES), kidney cancer cells (RXF-393), prostate cancer cells (DV), and breast cancer cells (BT-549) [23].…”

Section: Discussionmentioning

confidence: 99%

“…Despite our in-depth knowledge of the pathogenesis of melanoma, prognosis and patient survival remain a challenge. It is estimated that melanoma is responsible for 65-75% of skin cancer deaths each year [1]. Although the mean age of diagnosis is 63 years, the incidence increases with age.…”

Section: Introductionmentioning

confidence: 99%

Preclinical Study of Immunological Isoxazole Derivatives as a Potential Support for Melanoma Chemotherapy

Jęśkowiak

Wiatrak

Szeląg

et al. 2021

IJMS

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(1) Background: Melanoma is an aggressive neoplasm derived from melanocyte precursors with a high metastatic potential. Responses to chemotherapy and immunotherapy for melanoma remain weak, underlining the urgent need to develop new therapeutic strategies for the treatment of melanoma. (2) Methods: The viability of NHDF and A375 cell cultures after the administration of the tested isoxazole derivatives was assessed after 24-h and 48-h incubation periods with the test compounds in the MTT test. ROS and NO scavenging analyses, a glycoprotein-P activity analysis, a migration assay, a test of apoptosis, and a multiple-criteria decision analysis were also performed. (3) Results: All compounds that were tested resulted in a slower migration of melanoma neoplastic cells. The mechanism of the antitumor activity of the tested compounds was confirmed—i.e., the pro-apoptotic activity of the compounds in A375 cell cultures. Compound O7K qualified for further research. (4) Conclusions: All the tested compounds inhibited the formation of melanoma metastases and demonstrated the ability to reduce the risk of developing drug resistance in the tumor. The MCDA results showed that O7K showed the strongest antitumor activity.

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“…Melanoma is an aggressive and often fatal form of skin cancer, and its global incidence is increasing, constituting a serious public health problem [1,2]. This pathology is characterized by the malignant proliferation of melanocytes, cells responsible for melanin production, that can be caused by genetic, epigenetic, and/or environmental factors [1,3,4]. The risk of developing this type of cancer appears to be sex-independent but varies according to the skin phototype and geographic location, with a higher incidence rate in Caucasian individuals and inhabitants of regions with an excessive exposition to ultraviolet (UV) radiation [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval

Matias

Pinho

Penetra

et al. 2021

Cells

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Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and safer therapies is required. In this review, the different research steps involved in the process of antimelanoma drug evaluation and selection are explored, including information regarding in silico, in vitro, and in vivo experiments, as well as clinical trial phases. Details are given about the most used cell lines and assays to perform both two- and three-dimensional in vitro screening of drug candidates towards melanoma. For in vivo studies, murine models are, undoubtedly, the most widely used for assessing the therapeutic potential of new compounds and to study the underlying mechanisms of action. Here, the main melanoma murine models are described as well as other animal species. A section is dedicated to ongoing clinical studies, demonstrating the wide interest and successful efforts devoted to melanoma therapy, in particular at advanced stages of the disease, and a final section includes some considerations regarding approval for marketing by regulatory agencies. Overall, considerable commitment is being directed to the continuous development of optimized experimental models, important for the understanding of melanoma biology and for the evaluation and validation of novel therapeutic strategies.

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New insights on the role of autophagy in the pathogenesis and treatment of melanoma

Cited by 23 publications

References 93 publications

Loss of autophagy affects melanoma development in a manner dependent on PTEN status

Loss of autophagy affects melanoma development in a manner dependent on PTEN status

Preclinical Study of Immunological Isoxazole Derivatives as a Potential Support for Melanoma Chemotherapy

The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval

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