New Insights on the Role of Sodium in the Physiological Regulation of Blood Pressure and Development of Hypertension

Polychronopoulou, Erietta; Braconnier, Philippe; Burnier, Michel

doi:10.3389/fcvm.2019.00136

Cited by 20 publications

(18 citation statements)

References 69 publications

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“…In this study, creatinine concentration in Group III decreased from day 3 to day 10 of oral administration of the extract. Sodium, one of the body's important extracellular electrolytes have various functions especially in the kidney where it regulates blood pressure and blood volume and also regulates the acid-base balance of blood and body fluids (Polychronopoulou et al, 2019). Sodium concentration across the groups were not significantly different on day 3.…”

Section: Discussionmentioning

confidence: 86%

Effect of ethanol extract of <i>Aframomum angustifolium</i> seeds on potassium bromate induced liver and kidney damage in Wistar rats

Ebhohimen¹,

Ebhomielen²,

Edemhanria³

et al. 2020

Glo Jnl Pure Appl Sci

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The continued use of potassium bromate in some food and cosmetic products in Nigeria against regulatory provision has continually exposed Nigerians to its deleterious effect. The mechanism of bromate induced damage in the liver and kidney is through oxidative stress. Phytochemicals have antioxidant capacity and have gained research interest in the management of oxidative stress. In this study, the effect of the ethanol extract of Aframomum angustifolium seed on kidney and liver damage induced by exposure to an acute dose of potassium bromate was measured using appropriate biomarkers. Eighteen male Wistar rats, randomly divided into 3 groups were used for the study. Group I (normal control) received distilled H2O; Group II (positive control) received 400 mg/kgbw bromate once while Group III (test) received same acute dose as Group II but thereafter treated with an oral dose of ethanol extract (750 mg/kgbw) for 10days. Half the populations of each group were sacrificed on day 3 while the remaining was sacrificed on day 10 of treatment. Liver and kidney tissues as well as blood samples were collected for analysis. Biochemical parameters; malondialdehyde, creatinine, electrolytes (Na+ and K+) concentration as well as catalase, alanine aminotransferase and alkaline phosphatase activities were measured using standard spectrophotometric procedures. In the kidney tissue, malondialdehyde concentration increased significantly in all groups from day 3 to day 10 but was highest in Group II. A similar trend was observed in the liver tissue but only group III increased significantly. Catalase activity was inhibited in Group II in both kidney and liver tissues and was significantly lower than test group. Serum Na+ decreased and K+ increased respectively but Group III were comparable to the Group I. Creatinine concentration increased in all groups but was highest in Group II though it was not significant. ALP activity was significantly higher (p<0.05) in Group III on day 3 compared to Group I but was not significantly different (p>0.05) on day 10. The results of this study suggests that ethanol extract of Aframomum angustifolium seeds can accelerate the in vivo repair of bromate induced hepato- and reno- toxicity in Wistar rats. Keywords: Aframomum angustifolium, bromate toxicity, malondialdehyde, antioxidant, phytochemicals.

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Section: Discussionmentioning

confidence: 86%

Effect of ethanol extract of <i>Aframomum angustifolium</i> seeds on potassium bromate induced liver and kidney damage in Wistar rats

Ebhohimen¹,

Ebhomielen²,

Edemhanria³

et al. 2020

Glo Jnl Pure Appl Sci

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show abstract

“…63,64 There is a proposed link between fluid overload, systemic inflammation and ensuing malnutrition and endothelial dysfunction (perhaps through gut congestion and endotoxaemia). 65 In vivo tissue sodium visualization through 23 Na MRI can be correlated with disrupted proinflammatory markers in larger studies to better understand mechanistic pathways of how tissue sodium can accelerate a pro-inflammatory profile, particularly in the CKD population.…”

Section: Changes In Tissue Sodium Concentration In Patients With Kidney Failurementioning

confidence: 99%

Magnetic resonance imaging determination of tissue sodium in patients with chronic kidney disease

2021

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Excess sodium is a major modifiable contributor to hypertension and cardiovascular risk. Knowledge of sodium storage and metabolism has derived mainly from indirect measurements of dietary sodium intake and urinary sodium excretion, however both attempt to measure body sodium and fluid in a two-compartment model of intracellular and extracellular spaces. Our understanding of total body sodium has recently included a storage pool in tissues. In the last two decades, sodium-23 magnetic resonance imaging ( 23 Na MRI) has allowed dynamic quantification of tissue sodium in vivo. Tissue sodium is independently associated with cardiovascular dysfunction and inflammation. This review explores (i) The revolution of our understanding of sodium physiology, (ii) The development and potential clinical adoption of 23 Na MRI to provide improved measurement of total body sodium in CKD and (iii) How we can better understand mechanistic and clinical implications of tissue sodium in hypertension, cardiovascular disease and immune dysregulation, especially in the CKD population.

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“…Both these factors result in initiation of inflammation, which could result in vascular and renal hypertension owing to impaired natriuresis. 6 Table 1 Types of salt and their uses…”

Section: Salt and Its Physiological Role In Immunity Hypertension And Gut Microbiomementioning

confidence: 99%

Salt and skin

Prarthana

Karthikeyan

2021

Int J Dermatology

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The introduction of salt as a therapeutic agent in dermatological disorders has been in use since ancient times. This ubiquitous agent is the most underrated substance after the advent of modern medicine. Though a commonly used agent in both traditional and modern medicine, it is important to understand its relationship to the skin to further enhance the comprehensive benefit. The complex history of the evolution of medicine and its skewed distribution among the countries of the world led to inclusion of locally available and economical agents into therapeutics as it becomes almost an inevitable need.Moreover, an inadequate knowledge about the harmful effects of chronic salt exposure led salt to have a unique role in occupational dermatoses. There is no adequate literature on both detrimental and therapeutic effects of salt and its relation to skin. Hence, a genuine attempt was made to summarize the known and the lesser known facts of this particular common seasoning agent.

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New Insights on the Role of Sodium in the Physiological Regulation of Blood Pressure and Development of Hypertension

Cited by 20 publications

References 69 publications

Effect of ethanol extract of <i>Aframomum angustifolium</i> seeds on potassium bromate induced liver and kidney damage in Wistar rats

Effect of ethanol extract of <i>Aframomum angustifolium</i> seeds on potassium bromate induced liver and kidney damage in Wistar rats

Magnetic resonance imaging determination of tissue sodium in patients with chronic kidney disease

Salt and skin

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