New Insights on Saccus vasculosus Evolution: A Developmental and Immunohistochemical Study in Elasmobranchs

Sueiro, Catalina; Carrera, Iván; Ferreiro, Susana; Molíst, Pilar; Adrio, Fátima; Anadón, Ramón; Rodríguez‐Moldes, Isabel

doi:10.1159/000104309

Cited by 47 publications

(44 citation statements)

References 106 publications

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“…These results suggest that coronet cells in the SV contain entire photoperiodic signalling pathway from light input (photoreceptor) to neuroendocrine output (TSHb and DIO2). The coronet cells have traditionally been considered to be responsible for the function of the SV [14][15][16] , and our results are consistent with this notion. As the circadian clock is involved in photoperiodic time measurement, we also examined and confirmed expression of circadian clock genes in the SV ( Supplementary Fig.…”

Section: Resultssupporting

confidence: 91%

“…1a-e). The SV is a specialised circumventricular organ found in the caudal hypothalamus of many jawed fish, but its physiological function remains unclear [14][15][16] . Biological activity of TSH requires heterodimerization of the TSH b-subunit and a common glycoprotein a-subunit.…”

Section: Resultsmentioning

confidence: 99%

“…The SV consists of three types of cells: coronet (crown) cells, cerebrospinal fluid (CSF)-contacting cells and supporting cells. Coronet cells are characterized by an apical crown of globule-tipped cilia protruding into the ventricle 16 ( Fig. 3a), whereas the CSF-contacting neurons are bipolar neurons with a knob-like structure; their morphology resembles that of photoreceptor cells in the developing retina 18 .…”

Section: Resultsmentioning

confidence: 99%

“…Since then, its existence was confirmed in various species, and Gottsche (1835) 26 named this tissue the 'saccus vasculosus' and demonstrated that the SV has secretory function. Thereafter, the SV has been suggested to be involved in sensory and transport functions as well as secretory functions (for example, liquor pressure perception, osmoregulation, calcium homeostasis, glucose loading and transcellular ion exchange between blood vessels and CSF) 15,16,27 . However, its function has remained mysterious.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we cannot exclude the possibility that the SV has other physiological functions in addition to serving as the seasonal sensor. Afferent and efferent fibre systems relating the SV and the hypothalamus to each other have been reported 14,16,27,35 . A close developmental relationship between the neurohypophysis and caudal wall of the infundibulum has also been reported 36 .…”

Section: Discussionmentioning

confidence: 99%

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The saccus vasculosus of fish is a sensor of seasonal changes in day length

et al. 2013

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The pars tuberalis of the pituitary gland is the regulatory hub for seasonal reproduction in birds and mammals. Although fish also exhibit robust seasonal responses, they do not possess an anatomically distinct pars tuberalis. Here we report that the saccus vasculosus of fish is a seasonal sensor. We observe expression of key genes regulating seasonal reproduction and rhodopsin family genes in the saccus vasculosus of masu salmon. Immunohistochemical studies demonstrate that all of these genes are expressed in the coronet cells of the saccus vasculosus, suggesting the existence of a photoperiodic signalling pathway from light input to neuroendocrine output. In addition, isolated saccus vasculosus has the capacity to respond to photoperiodic signals, and its removal abolishes photoperiodic response of the gonad. Although the physiological role of the saccus vasculosus has been a mystery for several centuries, our findings indicate that the saccus vasculosus acts as a sensor of seasonal changes in day length in fish.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The saccus vasculosus of fish is a sensor of seasonal changes in day length

et al. 2013

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Development of the serotoninergic system in the central nervous system of a shark, the lesser spotted dogfish Scyliorhinus canicula

Carrera

Molíst

Anadón

et al. 2008

J of Comparative Neurology

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Chondrychthyans (cartilaginous fishes) are key to understanding the ancestral gnathostome condition since they provide an outgroup to sarcopterygians and actinopterygians. To gain comparative knowledge about the development of the vertebrate serotoninergic systems, we studied by immunohistochemistry the origin, spatiotemporal organization, and migration patterns of serotonin-containing neurons and the growth of axonal pathways in the central nervous system of a shark, the lesser spotted dogfish. Hindbrain serotonin-immunoreactive cells arose close to the floor plate and most populations migrated ventrally and mediolaterally to form the various raphe and reticular groups. The order of appearance of serotoninergic populations in the rhombencephalon and spinal cord (first the superior groups and then the inferior and spinal populations) roughly matched with that reported in other vertebrates but important differences were noted in the formation of prosencephalic groups in fishes. In addition to preoptic and hypothalamic areas, serotoninergic cerebrospinal fluid-contacting cells were observed in the isthmus (raphe dorsalis anterioris). Transient serotonin-immunoreactive cells were noted in the pineal organ, habenula, and pretectum. Further, we provide a revised anatomical framework for reticular and raphe serotoninergic populations considering their origin and segmental organization. Two distinct phases of development of the serotoninergic innervation were distinguished, that of the formation of the main axonal pathways and that of the branching of fibers. The development of main serotoninergic ascending pathways in dogfish was notably similar to that described in mammals. Our findings suggest the conservation of developmental patterns in serotoninergic systems and enhance the importance of elasmobranchs for understanding the early evolution of this system in vertebrates.

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Distribution of glycine immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): Comparison with γ-aminobutyric acid

2011

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Glycine and γ-aminobutyric acid (GABA) are the main inhibitory neurotransmitters in the central nervous system (CNS) of vertebrates. Studies on the distribution of glycinergic neurons and fibers have been carried out mainly in rodents and lampreys. With the aim of discovering more about the early evolution of this system in vertebrates, we analyzed the distribution of glycine-immunoreactive (Gly-ir) neurons and fibers in the CNS of a basal ray-finned fish, the Siberian sturgeon (Chondrostei, Acipenseriformes), by use of immunohistochemical techniques. We also compared the distribution of glycine and GABA by the use of double-immunofluorescence techniques and confocal microscopy. Our results revealed the presence of Gly-ir cells in different regions of the CNS, such as olfactory bulbs, preoptic area, hypothalamus, thalamus, pretectum, optic tectum, tegmentum and rostral spinal cord, although most of the Gly-ir cells and the most intensely immunoreactive cells were located in the rhombencephalon, mainly in the octavolateral area and reticular formation. In addition, coronet cells of the basal hypothalamus and saccus vasculosus were Gly-ir. Glycinergic fibers coursed along most brain regions and were more abundant in the thalamus, hypothalamus, optic tectum, tegmentum, isthmic region, and basal rhombencephalon. The Mauthner cell perikaryon was richly innervated by Gly-ir boutons, as reported for teleosts. With regard to the colocalization of glycine and GABA, double-immunoreactive cells were located mainly in the rhombencephalon. The results enable us to conclude that the distribution of glycine in the sturgeon brain is more similar to that observed in lampreys than that observed in mammals.

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New Insights on Saccus vasculosus Evolution: A Developmental and Immunohistochemical Study in Elasmobranchs

Cited by 47 publications

References 106 publications

The saccus vasculosus of fish is a sensor of seasonal changes in day length

The saccus vasculosus of fish is a sensor of seasonal changes in day length

Development of the serotoninergic system in the central nervous system of a shark, the lesser spotted dogfish Scyliorhinus canicula

Distribution of glycine immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): Comparison with γ-aminobutyric acid

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