New insights on metastrongyloid lungworms infecting cats of Sardinia, Italy

Tamponi, Claudia; Varcasia, Antonio; Brianti, Emanuele; Pipia, Anna Paola; Frau, V.; Parpaglia, Maria Luisa Pinna; Sanna, G.; Garippa, Giovanni; Otranto, Domenico; Scala, Antonio

doi:10.1016/j.vetpar.2014.04.001

Cited by 42 publications

(53 citation statements)

References 21 publications

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“…A field trial study was conducted in three geographical sites of Italy, (i.e., Messina, Sassari and Bari), where the occurrence of feline lungworm infections had been previously reported (Brianti et al, 2012;Annoscia et al, 2014;Giannelli et al, 2014a;Tamponi et al, 2014). From May to September 2014, client owned cats, which had regular access to the outdoor environment, were clinically examined.…”

Section: Prevalence Of Endoparasite Infections In Cats At the Enrolmentmentioning

confidence: 99%

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Giannelli

Brianti

Varcasia

et al. 2015

Veterinary Parasitology

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The increasing reports of Aelurostrongylus abstrusus infection and the new information on Troglostrongylus brevior have spurred the interest of the scientific community towards the research of pharmaceutical compounds effective against both pathogens. A novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®, Merial) has been released for the treatment of a variety of feline parasitic infections. The present study reports the efficacy of this spot-on in treating cats naturally infected by feline lungworms. Client owned cats (n=191) were enrolled from three geographical areas of Italy and faecal samples were examined by floatation and Baermann techniques. Twenty-three individuals were positive for L1 of A. abstrusus (n=18) or T. brevior (n=3) or for both species (n=2) and they were topically treated with Broadline®. Seventeen of them were also concomitantly infected by other parasites. Four weeks after treatment, faecal samples were collected and examined to assess the efficacy of a single administration of the product. Based on lungworm larvae counts, the efficacy of the treatment was 90.5% or 100% for A. abstrusus or T. brevior, respectively. Cats released significantly lower amounts of lungworm larvae after treatment compared to pre-treatment (p<0.0001). All but three cats were negative for other nematodes after treatment and all cats recovered from respiratory signs. Results of this study indicate that a single administration of the topical combination fipronil, (S)-methoprene, eprinomectin and praziquantel is effective and safe for the treatment of A. abstrusus and/or T. brevior infections in cats living under field conditions.

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Section: Prevalence Of Endoparasite Infections In Cats At the Enrolmentmentioning

confidence: 99%

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Giannelli

Brianti

Varcasia

et al. 2015

Veterinary Parasitology

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“…4,5 T brevior and A abstrusus have a similar indirect biological life cycle with estimated prepatent period of 4–6 weeks, while C aerophila has a direct life cycle. 4,6,7 It is possible that T brevior , found primarily in the Old World, might also be passed vertically in a transmammary fashion from queen to offspring.…”

Section: Discussionmentioning

confidence: 88%

“…4,5,8 Kittens and young cats seem to be particularly susceptible to infection with T brevior , and clinical signs include severe cough, respiratory distress and nasal discharge. Infection can lead to fatal respiratory failure in kittens, despite treatment.…”

Section: Discussionmentioning

confidence: 99%

Respiratory distress associated with lungworm infection in a kitten

Hawley

Johnson

Traversa

et al. 2016

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 5-month-old feral kitten developed worsening respiratory signs, including tachypnea, coughing and wheezing after standard anthelmintic treatment with fenbendazole at a local shelter. The kitten was referred to the University of California, Davis, William R Pritchard Veterinary Medicine Teaching Hospital for further evaluation. Thoracic radiographs revealed a severe diffuse bronchointerstitial pattern with bronchial cuffing, ill-defined nodules and lymphadenomegaly. Differentials included infectious etiologies such as toxoplasmosis, feline infectious peritonitis and cryptococcosis. Parasitic infection was considered less likely, owing to previous anthelmintic treatment. Bronchoalveolar lavage revealed marked neutrophilic and eosinophilic inflammation, and parasitic larvae were observed in a swab of trachea mucus. PCR confirmed the larvae as Aelurostrongylus abstrusus. The kitten recovered with two more rounds of anthelmintic treatment.Relevance and novel informationParasitic pneumonia should be considered as a cause of respiratory distress in kittens and cats. Lungworm infections have been more commonly reported in free-roaming young and adult cats, but cannot be excluded as a differential diagnosis in cats from varied environments and in kittens. Kittens appear to be especially sensitive to lungworm infections, manifested by the development of more severe clinical signs; thus lungworm infection should always be considered when presented with a kitten in respiratory distress. In the absence of cytologic confirmation of infection via bronchoalveolar lavage or oropharyngeal swab, PCR provides a valuable means for identification of lungworms, such as A abstrusus and Troglostrongylus brevior.

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“…17 C aerophila is found in the submucosa of the trachea, bronchi and bronchioles. 2,16 Mixed infections by respiratory nematodes are sometimes reported 7,9,14,[18][19][20] and both Troglostrongylus species and O rostratus may be more prevalent than presumed in domestic cats since there is a risk at UNIV MASSACHUSETTS AMHERST on July 6, 2015 jfm.sagepub.com Downloaded from that these infections are being misdiagnosed as A abstrusus because of morphometric similarities of their first-stage larvae (L1) in faeces. 3,4 Paragonimus species are lung flukes reported in many animals, including cats and humans, and some species are of zoonotic concern.…”

Section: Disease Agentsmentioning

confidence: 99%