New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes

Chen, Yanxia; Wang, Mian

doi:10.2147/dddt.s334325

Cited by 13 publications

(3 citation statements)

References 139 publications

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“… 14 Interestingly, intestinal barrier injury is independently driven by hyperglycemia, 15 and our previous study has further confirmed the relationship between intestinal barrier injury and hyperglycemia in humans. 16 In addition to the negative effects of hyperglycemia on the intestinal barrier and sepsis, some anti-hyperglycemic agents have been proven to protect against intestinal barrier injury 17 and alleviate sepsis-induced organ dysfunction in numerous animal experiments. 18 …”

Section: Introductionmentioning

confidence: 99%

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang¹,

Li²,

Wang³

et al. 2022

DDDT

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Intestinal barrier injury and hyperglycemia are common in patients with sepsis. Bacteria translocation and systemic inflammatory response caused by intestinal barrier injury play a significant role in sepsis occurrence and deterioration, while hyperglycemia is linked to adverse outcomes in sepsis. Previous studies have shown that hyperglycemia is an independent risk factor for intestinal barrier injury. Concurrently, increasing evidence has indicated that some anti-hyperglycemic agents not only improve intestinal barrier function but are also beneficial in managing sepsis-induced organ dysfunction. Therefore, we assume that these agents can block or reduce the severity of sepsis by improving intestinal barrier function. Accordingly, we explicated the connection between sepsis, intestinal barrier, and hyperglycemia, overviewed the evidence on improving intestinal barrier function and alleviating sepsis-induced organ dysfunction by anti-hyperglycemic agents (eg, metformin, peroxisome proliferators activated receptor-γ agonists, berberine, and curcumin), and summarized some common characteristics of these agents to provide a new perspective in the adjuvant treatment of sepsis.

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Section: Introductionmentioning

confidence: 99%

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Wang¹,

Li²,

Wang³

et al. 2022

DDDT

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“…In recent years, with the development of metagenomic studies, there has been a growing awareness of the important role of the gastrointestinal microbiome in public health and diseases, including digestive system diseases such as in ammatory bowel disease [28], colorectal cancer [29], irritable bowel symptoms [30], and parenteral diseases such as diabetes [31,32], coronary heart disease [33,34], and Alzheimer's disease [35,36]. An imbalance of the gastrointestinal microbiome occurs early in the development of SAP.…”

Section: Discussionmentioning

confidence: 99%

Interaction between Acute Pancreatitis and Gastrointestinal Microbiome: A Bidirectional Two-sample Mendelian Randomization Study

Wang,

Zhang

et al. 2024

Preprint

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Background: Previous studies have shown that the severity of acute pancreatitis correlates with the gastrointestinal microbiome and that the development of acute pancreatitis causes changes in the gastrointestinal microbiome. However, there is no known genetic mechanism of action to explain the relationship between acute pancreatitis and the gastrointestinal microbiome. Methods: We performed a two-sample MR analysis of publicly available GWAS data on the gastrointestinal microbiome and acute pancreatitis. We applied several MR methods to explore causal associations, including inverse variance weights, weighted medians, MR‒Egger, Wald ratios, and MR-PRESSO. Sensitivity analyses and Cochrane's Q tests were also performed to exclude the effects of pleiotropy and heterogeneity. Results: IVW showed that enrichment of the Eubacterium rectale group, Holdemania and Terrisporobacter was correlated with the severity of acute pancreatitis. Inverse MR analyses revealed that the acute pancreatitis affected the abundance of Allisonella, Anaerotruncus, Paraprevotella, Erysipelotrichaceae UCG003, Family XIII AD3011 group, Haemophilus, Intestinibacter, Turicibacter and Tyzzerella 3. Conclusions: This study elucidates the association between acute pancreatitis and gastrointestinal microbiome at the level of genetic variation, but the mechanism of action needs to be further explored.

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“…Palmitic acid has antibacterial activity [ 61 ], and a compressed mixture of insulin and palmitic acid can sustain a reduction in hyperglycemia in rodents [ 62 ]. Additionally, research shows that deoxycholic acid-triazole conjugates have good inhibitory effects against B. subtilis [ 63 ]; deoxycholic acid is involved in improving glucose metabolism to ameliorate hyperglycemia [ 64 ]. In short, we have found 6 possible components of corn silk with antibacterial and hyperglycemia activities.…”

Section: Discussionmentioning

confidence: 99%

Extraction Optimization, Preliminary Identification, and Bioactivities in Corn Silk

Ren

Sun

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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For thousands of years, corn silk has been widely used as an antidiabetic, antioxidant, and antihyperlipidemic and for other effects, but there is a lack of studies that correlate the extracts of flavonoid composition with their biological activities. Thus, the objectives of this study were to optimize the conditions for extracting flavonoids, identify flavonoids, and correlate the flavonoid composition with the biological activities in corn silk. The response surface experiments showed that the highest flavonoid content was predicted at 45.321 min, 57.349°C, 26.089 mL/g, and 71.269%, respectively. The verification experiment results under these optimized conditions showed an ultrasonic time of 45 min, an ultrasonic temperature of 57°C, a liquid-to-material ratio of 26, and an ethanol volume fraction of 70%. No significant differences (the relative error is 4.378%) were observed between the theoretical and experimental TFC values, indicating that the developed models were accurate. Under these optimum extraction conditions, 20 major compounds were identified and quantified by UPLC-LTQ/Orbitrap MS. Furthermore, these optimum ethanol extracts of corn silk are effective against Bacillus subtilis and hypoglycemic activity compared with the traditional heating reflux extraction method. Six corn silk components seem to be the main contributors to the inhibitory effect against Bacillus subtilis and hyperglycemia activities. These results are useful for the application of corn silk in the food or pharmaceutical industry.

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New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes

Cited by 13 publications

References 139 publications

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Anti-Hyperglycemic Agents in the Adjuvant Treatment of Sepsis: Improving Intestinal Barrier Function

Interaction between Acute Pancreatitis and Gastrointestinal Microbiome: A Bidirectional Two-sample Mendelian Randomization Study

Extraction Optimization, Preliminary Identification, and Bioactivities in Corn Silk

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