New insights into therapeutic strategies for gut microbiota modulation in inflammatory diseases

Vieira, Angélica T.; Fukumori, Claudio; Ferreira, Caroline M.

doi:10.1038/cti.2016.38

Cited by 90 publications

(84 citation statements)

References 100 publications

(221 reference statements)

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“…Moreover, gut microbiota–host interactions serve as an essential target for development of new therapeutic strategies such as: fecal microbiota transplant (FMT) in the therapy of C. difficile infection, hepatic encephalopathy and gastrointestinal and behavioral symptoms of autism spectrum disorders; stool‐substitute therapies in the treatment of C. difficile infection; and the implementation of FMT, non‐traditional probiotics (e.g. F. prausnitzii and Clostridium butyricum ) and postbiotics (bacterial products and metabolic byproducts of probiotic organisms) in the therapy of inflammatory diseases . Studies on these treatment techniques are in progress worldwide.…”

Section: Resultsmentioning

confidence: 99%

Association between the gut microbiota and mineral metabolism

2017

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The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals, and the effect of this interaction on the health of the host. The Web of Science database from the years 2013-2017 on this topic was reviewed. Numerous in vitro studies have shown that iron significantly affects the intestinal microbiota. However, Bifidobacteriaceae are capable of binding iron in the large intestine, thereby limiting the formation of free radicals synthesized in the presence of iron, and thus reducing the risk of colorectal cancer. Animal studies have revealed that supplementation with probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic interaction between microbiota and zinc was shown. Human studies have provided evidence of the influence of probiotic bacteria on parathormone, calcium and phosphate levels and thus on bone resorption. Recent studies have produced new information mainly on the impact of the intestinal bacteria on the metabolism of calcium and iron. From a scientific perspective, the most urgent fields that remain to be investigated are the identification of all human gut microbes and new therapies targeting the interaction between intestinal bacteria and minerals. © 2017 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 99%

Association between the gut microbiota and mineral metabolism

2017

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“…Recently, interest in probiotic research expanded from the classical probiotic Lactobacillus and Bifidobacterium species to a more targeted manipulation of the host gut microbiota with ‘personalized probiotic therapies’ using functional important strict anaerobic gut microbes. The administration of specific bacterial strains could address distinct differences in colonic microbiota profiles associated with intestinal diseases (Vieira et al ., ). Strict anaerobic butyrate‐producing bacteria have been proposed as ‘next‐generation probiotics’ in the treatment of intestinal disorders (Van Immerseel et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Effect of cryopreservation and lyophilization on viability and growth of strict anaerobic human gut microbes

Bircher

Geirnaert

Hammes

et al. 2018

Microbial Biotechnology

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SummaryStrict anaerobic gut microbes have been suggested as ‘next‐generation probiotics’ for treating several intestinal disorders. The development of preservation techniques is of major importance for therapeutic application. This study investigated cryopreservation (−80°C) and lyophilization survival and storage stability (4°C for 3 months) of the strict anaerobic gut microbes Bacteroides thetaiotaomicron, Faecalibacterium prausnitzii, Roseburia intestinalis, Anaerostipes caccae, Eubacterium hallii and Blautia obeum. To improve preservation survival, protectants sucrose and inulin (both 5% w/v) were added for lyophilization and were also combined with glycerol (15% v/v) for cryopreservation. Bacterial fitness, evaluated by maximum growth rate and lag phase, viability and membrane integrity were determined using a standardized growth assay and by flow cytometry as markers for preservation resistance. Lyophilization was more detrimental to viability and fitness than cryopreservation, but led to better storage stability. Adding sucrose and inulin enhanced viability and the proportion of intact cells during lyophilization of all strains. Viability of protectant‐free B. thetaiotaomicron, A. caccae and F. prausnitzii was above 50% after cryopreservation and storage and increased to above 80% if protectants were present. The addition of glycerol, sucrose and inulin strongly enhanced the viability of B. obeum, E. hallii and R. intestinalis from 0.03–2% in protectant‐free cultures to 11–37%. This is the first study that quantitatively compared the effect of cryopreservation and lyophilization and the addition of selected protectants on viability and fitness of six strict anaerobic gut microbes. Our results suggest that efficiency of protectants is process‐ and species‐specific.

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“…Anti-inflammatory roles of the gut microbiota have shown promising results in treating colorectal cancer [240][241][242], ulcers [243,244] and chemical-induced damages in the small intestine [245,246]. Modulation of the gut microbiota can be efficiently used to manage several gastrointestinal disorders [247]. Different potential strategies viz.…”

Section: Gut Microbes As Therapeuticsmentioning

confidence: 99%

Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings

Mukherjee

Joardar

Sengupta

et al. 2018

The Journal of Nutritional Biochemistry

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The human gut microbiota has been the interest of extensive research in recent years and our knowledge on using the potential capacity of these microbes are growing rapidly. Microorganisms colonized throughout the gastrointestinal tract of human are coevolved through symbiotic relationship and can influence physiology, metabolism, nutrition and immune functions of an individual. The gut microbes are directly involved in conferring protection against pathogen colonization by inducing direct killing, competing with nutrients and enhancing the response of the gut-associated immune repertoire. Damage in the microbiome (dysbiosis) is linked with several life-threatening outcomes viz. inflammatory bowel disease, cancer, obesity, allergy, and auto-immune disorders. Therefore, the manipulation of human gut microbiota came out as a potential choice for therapeutic intervention of the several human diseases. Herein, we review significant studies emphasizing the influence of the gut microbiota on the regulation of host responses in combating infectious and inflammatory diseases alongside describing the promises of gut microbes as future therapeutics.

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New insights into therapeutic strategies for gut microbiota modulation in inflammatory diseases

Cited by 90 publications

References 100 publications

Association between the gut microbiota and mineral metabolism

Association between the gut microbiota and mineral metabolism

Effect of cryopreservation and lyophilization on viability and growth of strict anaerobic human gut microbes

Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings

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