New insights into the taxonomy of autoimmune diseases based on polyautoimmunity

Rojas, Manuel; Ramírez-Santana, Carolina; Acosta-Ampudia, Yeny; Monsalve, Diana M.; Rodríguez-Jiménez, Mónica; Zapata, Elizabeth; Naranjo-Pulido, Angie; Suárez-Avellaneda, Ana; Ríos-Serna, Lady J.; Prieto, Carolina; Zambrano-Romero, William; Valero, María Alejandra; Rodríguez, Yhojan; Mantilla, Rubén D.; Zhu, Chengsong; Li, Quan-Zhen; Gutierrez, C. E. Toro; Tobón, Gabriel J.; Anaya, Juan-Manuel

doi:10.1016/j.jaut.2021.102780

Cited by 12 publications

(12 citation statements)

References 49 publications

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“…In the last years, two important concepts in autoimmunity have been described: “Overt Polyautoimmunity” implying clinical coexistence of two or more ADs fulfilling classification criteria, and “Latent Polyautoimmunity” described as the presence of autoantibodies unrelated to an index AD, without clinical criteria fulfillment [ [28] , [29] , [30] ].…”

Section: Discussionmentioning

confidence: 99%

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Association of anti-SARS-COV-2 vaccine with increased incidence of myositis-related anti-RNA-synthetases auto-antibodies

García-Bravo

Rubio

Fernández‐Arquero

et al. 2022

Journal of Translational Autoimmunity

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Section: Discussionmentioning

confidence: 99%

“…Given the presence of MSAs autoantibodies, close monitoring should be necessary since prognostic and therapeutic implications may be important. Therefore, recent publications indicate that those patients with latent PolyA may develop overt PolyA in the future [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Association of anti-SARS-COV-2 vaccine with increased incidence of myositis-related anti-RNA-synthetases auto-antibodies

García-Bravo

Rubio

Fernández‐Arquero

et al. 2022

Journal of Translational Autoimmunity

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“…In this view, beside the acquired knowledge about regulatory T cells (Treg), regulatory B cells (Breg) gained interest in the pathogenesis of autoimmune diseases (3,4). Autoimmune diseases appear to follow a similar dysimmune pathogenic root and the association of multiple autoimmune disorders, both systemic and organspecific, is not unusual (5,6). Indeed, a recent study by Rojas et al (5) observed that polyautoimmunity more often occurs based on the presence of circulating autoantibodies without specific symptoms or signs, and this latent polyautoimmunity was found in about 100% of the patients with SSc.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Indeed, a recent study by Rojas et al. ( 5 ) observed that polyautoimmunity more often occurs based on the presence of circulating autoantibodies without specific symptoms or signs, and this latent polyautoimmunity was found in about 100% of the patients with SSc. In this context, Hashimoto’s thyroiditis (HT) represents the most common autoimmune disorder worldwide, whose clinical association with coexisting autoimmune diseases has also been described ( 7 – 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Regulatory B Cells in Systemic Sclerosis Isolated or Concomitant With Hashimoto Thyroiditis

et al. 2022

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Systemic sclerosis (SSc) is a systemic autoimmune disease in which gastrointestinal disorders represent a complication in up to 90% of patients. SSc may associate with thyroid autoimmune disorders, with Hashimoto’s thyroiditis (HT) being the more prevalent worldwide. Previous studies have examined the behavior of Th17 lymphocytes and Breg cells in patients with HT and concomitant autoimmune organ-specific disorders. These immune phenotypes seem to play a significant role in the pathogenesis of both these autoimmune processes, but their behavior when these two disorders coexist has not been described. We analyzed Th17 and Breg (CD24hiCD38hi) cell subsets in 50 subjects (45F/5M; median age = 49 years): 18 were healthy donors (HD), 20 had isolated HT, and 12 had SSc, seven of whom had both HT and SSc. Breg cells’ function was also evaluated by measuring their IL-10 production when stimulated by specific activators. An increased percentage of Th17 lymphocytes characterized HT patients as compared to both HD and the whole group of SSc patients (p = 0.0018). On the contrary, the percentage of unstimulated Breg cells in SSc patients was higher (p = 0.0260), either associated or not with HT, as compared to both HT patients and HD, which, instead, showed a similar percentage of Breg cells. Following a specific stimulation with CpG, the percentages of Breg cells were increased in the whole sample of SSc patients (p < 0.001) as well as in isolated SSc and in SSc+HT ones as compared to isolated HT. However, qualitative analysis, obtained through the detection of the IL-10-producing phenotype, revealed that the percentage of CpG-stimulated CD24hiCD38hi-IL10+cells was significantly decreased in SSc patients (p < 0.0001) with no difference between isolated SSc and SSc+HT patients. The IL-10-producing phenotype was instead slightly increased in HT patients as compared to HD (4.1% vs. 2.8%). The presence of SSc seems to be characterized by an enrichment of total Breg cells but by a reduced Breg IL-10-producing phenotype, representing functional Bregs. This last finding was entirely due to the presence of SSc independently from the association with HT. This behavior is different from the ones described about the association of HT with organ-specific autoimmune disorders.

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Ocular cicatricial pemphigoid: is there an association with autoimmune diseases?

Ringer,

Smichowski,

Gómez

et al. 2024

Int Ophthalmol

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New insights into the taxonomy of autoimmune diseases based on polyautoimmunity

Cited by 12 publications

References 49 publications

Association of anti-SARS-COV-2 vaccine with increased incidence of myositis-related anti-RNA-synthetases auto-antibodies

Association of anti-SARS-COV-2 vaccine with increased incidence of myositis-related anti-RNA-synthetases auto-antibodies

Regulatory B Cells in Systemic Sclerosis Isolated or Concomitant With Hashimoto Thyroiditis

Ocular cicatricial pemphigoid: is there an association with autoimmune diseases?

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