New insights into the structure-activity relationships of antioxidative peptide PMRGGGGYHY

Wü, Ray; Huang, Jiafeng; Huan, Ran; Chen, LeiLei; Chen, Yi; Liu, Dan; Wang, Meng; Liu, CongLing; He, Hui

doi:10.1016/j.foodchem.2020.127678

Cited by 35 publications

(25 citation statements)

References 30 publications

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“…Chemical groups, such as thiol in cysteine, thioether in methionine, phenolic hydroxyl in tyrosine, and indole in tryptophan and imidazolyl, contribute to the antioxidant activity of amino acids. 32,33 Moreover, recent studies also demonstrate that the carboxyl and amino groups promoted CDs to scavenging the ROS, which correspondingly enhanced the antioxidant activity of CDs. 15,27 Some studies suggest that the antioxidation activities associate with the proton donor role of surface groups like carboxyl groups.…”

Section: Resultsmentioning

confidence: 98%

Nitrogen and Sulfur Co-doped Carbon Dots Enhance Drought Resistance in Tomato and Mung Beans

Kou

Zhang

et al. 2021

ACS Appl. Bio Mater.

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Drought stress is widespread worldwide, which severely restricts world food production. The antioxidant property of carbon dots (CDs) is promising for inflammation and disease treatment. However, little is known about the functions of CDs in the abiotic stress of plants, especially in drought-resistant fields. In this study, CDs were synthesized using cysteine and glucose by the hydrothermal method. The in vitro antioxidant capacity of CDs and the reactive oxygen species (ROS) scavenging capacity were evaluated. We speculate on the antioxidant mechanism of CDs by comparing size distribution, fluorescence spectra, elements, and surface functional groups of CDs before and after oxidation. Besides, we evaluated the effects of CDs on seed germination and seedling physiology under drought stress. Also, the responses of antioxidant CDs to long-term drought stress and subsequent recovery metabolism in tomato plants were evaluated. The results show that CDs accelerated the germination rate and the germination drought resistance index by promoting the water absorption of seeds. CDs enhanced the drought resistance of seedlings by improving the activity of peroxidase (POD) and superoxide dismutase (SOD). Moreover, CDs can activate the antioxidant metabolism activity and upregulate the expression of aquaporin (AQP) genes SlPIP2;7, SlPIP2;12, and SlPIP1;7. All of these results render tomato plants distinguished resilience once rewatering after drought stress. These results facilitate us to design and fabricate CDs to meet the challenge of abiotic stress in food production.

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Section: Resultsmentioning

confidence: 98%

Nitrogen and Sulfur Co-doped Carbon Dots Enhance Drought Resistance in Tomato and Mung Beans

Kou

Zhang

et al. 2021

ACS Appl. Bio Mater.

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“…As shown in Figure 2 and Figure 3 a, the HOMOs of all dipeptides as well as FSEY are located at their active amino acid residues, that is, C, W, M, or Y. It indicates that these amino acids will firstly lose their electrons once when interacting with free radicals [ 41 ]. Clearly, data from the analysis of the HOMO site and linoleic acid oxidation inhibition confirmed the significance of active amino acid residues in determining the activity of antioxidant peptides.…”

Section: Resultsmentioning

confidence: 99%

“…These amino acids, which are crucial in scavenging free radicals, have been reported by several research works. Amino acids Tyr, Trp, Cys, and Met as well as peptides containing these amino acids showed activities against ABTS radicals and oxygen radicals (ORAC, oxygen radical absorbance capacity) [ 43 ], active against ROS or RNS [ 3 ], and effectively against AAPH-induced peroxyl radicals [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…By our DFT calculations, HOMOs of the tested peptides are located at their active amino acids, that is, Cys, Trp, Met, or Tyr (see Figure 2 ). The HOMOs of some peptides including EAAY, PMRGGGYHY, PMRGGYHY, PMRGYHY, PMRYHY, and YHY have been reported to be concentrated on the phenolic hydroxyl structure in Tyr [ 41 ]. The peptides PVETVR, QEPLLR, RDPEER, and LDDDGRL have the HOMOs of guanidyl in Arg, and the active sites of peptides KELEEK, DAAGRLQE, and GFAGDDAPRA are located at Lys-Glu, Gly, and Asp [ 24 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a similar study, Wang et al used E HOMO and E-gap to predicate the antioxidant activity of five peptides with only one exception [ 39 ]. Experiments conducted by Wu et al also indicated that E HOMO and E-gap were feasible to describe the antioxidant behaviors of a set of man-made peptides, which were designed from the parent peptide “PMRGGGGYHY” [ 41 ]. Consistent with other studies reported [ 44 ], the presence of active residues Tyr, Trp, or Met as well as high E HOMO and low E-gap should be the characteristics of a peptide responsible for inhibiting the oxidation of linoleic acid.…”

Section: Discussionmentioning

confidence: 99%

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A Novel Insight into Screening for Antioxidant Peptides from Hazelnut Protein: Based on the Properties of Amino Acid Residues

et al. 2022

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This study used the properties of amino acid residues to screen antioxidant peptides from hazelnut protein. It was confirmed that the type and position of amino acid residues, grand average of hydropathy, and molecular weight of a peptide could be comprehensively applied to obtain desirable antioxidants after analyzing the information of synthesized dipeptides and BIOPEP database. As a result, six peptides, FSEY, QIESW, SEGFEW, IDLGTTY, GEGFFEM, and NLNQCQRYM were identified from hazelnut protein hydrolysates with higher antioxidant capacity than reduced Glutathione (GSH) against linoleic acid oxidation. The peptides having Tyr residue at C-terminal were found to prohibit the oxidation of linoleic acid better than others. Among them, peptide FSEY inhibited the rancidity of hazelnut oil very well in an oil-in-water emulsion. Additionally, quantum chemical parameters proved Tyr-residue to act as the active site of FSEY are responsible for its antioxidation. This is the first presentation of a novel approach to excavating desired antioxidant peptides against lipid oxidation from hazelnut protein via the properties of amino acid residues.

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A comprehensive review of specific activity and intrinsic connections of food‐derived bioactive peptides for human health

Zhao,

Su,

Zhang

et al. 2024

Food Frontiers

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Food‐derived peptides have garnered significant attention in research due to their multifaceted functionalities, abundant availability, efficient utilization of agricultural by‐products, and environmentally sustainable preparation methods. These peptides play a crucial role in human health, yet their precise mechanisms of action remain largely unexplored, posing challenges in their screening, preparation, and effective application utilizing protein‐based raw materials. This review offers an extensive examination of 19 types of bioactive peptides derived from food. The sources of food‐derived bioactive peptides are well concluded and the classifications are made according to their potential health benefit based on five primary systems: general bodily functions, the nervous system, the cardiovascular system, the metabolic system, and the immune system. This review specifically highlights the multifaceted impacts of tasty peptides on human health, extending beyond their gustatory effects. Furthermore, it explores the interplay between various functions of bioactive peptides, noting a progression from basic to advanced functionalities. Antioxidant activity and the modulation of key enzymes are identified as fundamental actions that are interconnected with other functional properties. This implies that a single bioactive peptide could exhibit multiple beneficial effects. The key role of antioxidant capabilities is underscored based on their broad influence and straightforward assessment. This comprehensive analysis aims to deepen the systematic understanding of the diverse benefits offered by various food‐derived peptides.

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New insights into the structure-activity relationships of antioxidative peptide PMRGGGGYHY

Cited by 35 publications

References 30 publications

Nitrogen and Sulfur Co-doped Carbon Dots Enhance Drought Resistance in Tomato and Mung Beans

Nitrogen and Sulfur Co-doped Carbon Dots Enhance Drought Resistance in Tomato and Mung Beans

A Novel Insight into Screening for Antioxidant Peptides from Hazelnut Protein: Based on the Properties of Amino Acid Residues

A comprehensive review of specific activity and intrinsic connections of food‐derived bioactive peptides for human health

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