2014
DOI: 10.1534/genetics.113.159368
|View full text |Cite
|
Sign up to set email alerts
|

New Insights Into the Roles of NADPH Oxidases in Sexual Development and Ascospore Germination in Sordaria macrospora

Abstract: NADPH oxidase (NOX)-derived reactive oxygen species (ROS) act as signaling determinants that induce different cellular processes. To characterize NOX function during fungal development, we utilized the genetically tractable ascomycete Sordaria macrospora. Genome sequencing of a sterile mutant led us to identify the NADPH oxidase encoding nox1 as a gene required for fruiting body formation, regular hyphal growth, and hyphal fusion. These phenotypes are shared by Δnor1, lacking the NOX regulator NOR1. Further ph… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

5
105
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
7
3

Relationship

3
7

Authors

Journals

citations
Cited by 84 publications
(112 citation statements)
references
References 82 publications
(111 reference statements)
5
105
0
Order By: Relevance
“…We reported that the regulated production of ROS is essential for fungal sexual development (Lara-Ortíz et al, 2003; Cano-Domínguez et al, 2008), a finding demonstrated in several fungi (Malagnac et al, 2004; Siegmund et al, 2013; Dirschnabel et al, 2014). In addition to their roles in the antioxidant response, AtfA and SrrA play different roles in gene regulation during development.…”
Section: Discussionmentioning
confidence: 92%
“…We reported that the regulated production of ROS is essential for fungal sexual development (Lara-Ortíz et al, 2003; Cano-Domínguez et al, 2008), a finding demonstrated in several fungi (Malagnac et al, 2004; Siegmund et al, 2013; Dirschnabel et al, 2014). In addition to their roles in the antioxidant response, AtfA and SrrA play different roles in gene regulation during development.…”
Section: Discussionmentioning
confidence: 92%
“…These included data from protoperithecia of the wild type and two developmental mutants as well as wild type total vegetative and sexual mycelium (Teichert et al. 2012, Dirschnabel et al. 2014) (table 1).…”
Section: Resultsmentioning
confidence: 99%
“…A second NADPH oxidase, NOX2, contributes to but is not essential for these cellular reactions [66][67][68][69]. A current question of great interest in fungal cell biology is the potential connection between NOX complexes and MAP kinase cascades.…”
Section: Reactive Oxygen Speciesmentioning
confidence: 99%