New Insights into the Role of Respiratory Inputs in Hippocampal Oscillations

Lockmann, André L. V.; Belchior, Hindiael

doi:10.1523/jneurosci.1870-14.2014

Cited by 5 publications

(3 citation statements)

References 14 publications

(8 reference statements)

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“…Theta (4)(5)(6)(7)(8)(9)(10)(11)(12) and gamma are two of the most studied neuronal oscillations, though the exact definitions of their frequency ranges remain somewhat arbitrary and vary across laboratories. oscillations in the delta range associated with thalamocortical activity and up-and-down state transitions during sleep and deep anesthesia [8,14,15]. Figure 2A shows examples of respiration-entrained LFP oscillations during naturally occurring periods of awake immobility and exploration simultaneously recorded from the OB, mPFC, and parietal cortex of a mouse.…”

Section: Glossarymentioning

confidence: 99%

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

Tort

Brankačk

Draguhn

2018

Trends in Neurosciences

257

284

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We revisit recent evidence showing that nasal respiration entrains oscillations at the same frequency as breathing in several regions of the rodent brain. Moreover, respiration modulates the amplitude of a specific gamma sub-band (70-120Hz), most prominently in frontal regions. Since rodents often breathe at delta and theta frequencies, we caution that previous studies on delta and theta power and their cross-regional synchrony, as well as on delta-gamma and theta-gamma coupling, may have detected the respiration-entrained rhythm and respiration-gamma coupling. We argue that the simultaneous tracking of respiration along with electrophysiological recordings is necessary to properly identify brain oscillations. We hypothesize that respiration-entrained oscillations aid long-range communication in the brain.

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Section: Glossarymentioning

confidence: 99%

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

Tort

Brankačk

Draguhn

2018

Trends in Neurosciences

257

284

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“…The phase of low-frequency LFP oscillations can modulate the amplitude of faster oscillations (Colgin et al, 2009;Tort et al, 2009). During urethane anesthesia, the rat HPC exhibits three different rhythms with peak frequencies lower than 5 Hz: theta (~4 Hz), slow oscillations (SO,~0.7 Hz) coupled to the neocortical up-anddown states, and a rhythm coupled to nasal respiration (HRR,1 .2 Hz) (Wolansky et al, 2006;Lockmann & Belchior, 2014;Yanovsky et al, 2014;Lockmann et al, 2016). In our dataset, beta oscillations did not co-occur with SO, but co-occurred with HRR and theta.…”

Section: Nasal Respiration and Respiration-coupled Lfp Rhythms Modulamentioning

confidence: 99%

Olfactory bulb drives respiration‐coupled beta oscillations in the rat hippocampus

Lockmann

Laplagne

Tort

2017

Eur J of Neuroscience

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The synchronization of neuronal oscillations has been suggested as a mechanism to coordinate information flow between distant brain regions. In particular, the olfactory bulb (OB) and the hippocampus (HPC) have been shown to exhibit oscillations in the beta frequency range (10-20 Hz) that are likely to support communication between these structures. Here, we further characterize features of beta oscillations in OB and HPC of rats anesthetized with urethane. We find that beta oscillations simultaneously appear in HPC and OB and phase-lock across structures. Moreover, Granger causality analysis reveals that OB beta activity drives HPC beta. The laminar voltage profile of beta in HPC shows the maximum amplitude in the dentate gyrus (DG), spatially coinciding with olfactory inputs to this region. Finally, we also find that the respiratory cycle and respiration-coupled field potential rhythms (1-2 Hz)-but not theta oscillations (3-5 Hz)-modulate beta amplitude in OB and HPC. In all, our results support the hypothesis that beta activity mediates the communication between olfactory and hippocampal circuits in the rodent brain.

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“…These circuits for breathing have remarkable adaptive and emergent properties (Devinney et al 2013;Lindsey et al 1992Lindsey et al , 2012Ramirez et al 2012) and participate in the generation of numerous other behaviors (Bartlett and Leiter 2012), including vocal communication (McLean et al 2013), coughing and swallowing, and their coordinated expression as a metabehavioral response to aspiration Shannon et al 2000). Breathing may also bind orofacial sensations (Kleinfeld et al 2014) and be involved in hippocampal processes for learning and memory (Lockmann and Belchior 2014).…”

mentioning

confidence: 99%

Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network

Segers

Nuding

Ott

et al. 2015

Journal of Neurophysiology

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113: 352-368, 2015. First published October 15, 2014 doi:10.1152/jn.00542.2014.-Models of brain stem ventral respiratory column (VRC) circuits typically emphasize populations of neurons, each active during a particular phase of the respiratory cycle. We have proposed that "tonic" pericolumnar expiratory (t-E) neurons tune breathing during baroreceptor-evoked reductions and central chemoreceptor-evoked enhancements of inspiratory (I) drive. The aims of this study were to further characterize the coordinated activity of t-E neurons and test the hypothesis that peripheral chemoreceptors also modulate drive via inhibition of t-E neurons and disinhibition of their inspiratory neuron targets. Spike trains of 828 VRC neurons were acquired by multielectrode arrays along with phrenic nerve signals from 22 decerebrate, vagotomized, neuromuscularly blocked, artificially ventilated adult cats. Forty-eight of 191 t-E neurons fired synchronously with another t-E neuron as indicated by crosscorrelogram central peaks; 32 of the 39 synchronous pairs were elements of groups with mutual pairwise correlations. Gravitational clustering identified fluctuations in t-E neuron synchrony. A network model supported the prediction that inhibitory populations with spike synchrony reduce target neuron firing probabilities, resulting in offset or central correlogram troughs. In five animals, stimulation of carotid chemoreceptors evoked changes in the firing rates of 179 of 240 neurons. Thirty-two neuron pairs had correlogram troughs consistent with convergent and divergent t-E inhibition of I cells and disinhibitory enhancement of drive. Four of 10 t-E neurons that responded to sequential stimulation of peripheral and central chemoreceptors triggered 25 cross-correlograms with offset features. The results support the hypothesis that multiple afferent systems dynamically tune inspiratory drive in part via coordinated t-E neurons.

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New Insights into the Role of Respiratory Inputs in Hippocampal Oscillations

Cited by 5 publications

References 14 publications

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

Olfactory bulb drives respiration‐coupled beta oscillations in the rat hippocampus

Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network

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