New insights into the pathogenesis and therapy of Behçet's disease

Arayssi, Thurayya; Hamdan, Ayad

doi:10.1016/j.coph.2003.10.009

Cited by 45 publications

(28 citation statements)

References 42 publications

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“…Both Th1 and Th17 responses have been associated with human uveitis (Arayssi and Hamdan 2004;Amadi-Obi and others 2007;others 2007, 2008). Extrapolating from data in animal models, it is conceivable that at least some of those differences may be attributed to differences in the effector T cell lineage driving disease.…”

Section: Figmentioning

confidence: 97%

Cytokines in Autoimmune Uveitis

Horai

Caspi

2011

Journal of Interferon & Cytokine Research

150

114

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Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a known infectious trigger. The disorder is often associated with immunological responses to retinal proteins. Experimental models of autoimmune uveitis targeting retinal proteins have led to a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and have provided a template for the development of novel therapies. The disease in humans is believed to be T cell-dependent, as clinical uveitis is ameliorated by T cell-targeting therapies. The roles of T helper 1 (Th1) and Th17 cells have been major topics of interest in the past decade. Studies in uveitis patients and experiments in animal models have revealed that Th1 and Th17 cells can both be pathogenic effectors, although, paradoxically, some cytokines produced by these subsets can also be protective, depending on when and where they are produced. The major proinflammatory as well as regulatory cytokines in uveitis, the therapeutic approaches, and benefits of targeting these cytokines will be discussed in this review.

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Section: Figmentioning

confidence: 97%

Cytokines in Autoimmune Uveitis

Horai

Caspi

2011

Journal of Interferon & Cytokine Research

150

114

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“…58 A rare disorder in childhood that is characterized by pyrexia, pharyngitis, cervical lymphadenopathy and aphthous-like ulcers, sometimes termed PFAPA (periodic fever, aphthae, pharyngitis and adenitis), has also been described. 59 …”

Section: Recurrent Aphthous Stomatitismentioning

confidence: 99%

Ulcerative Lesions of the Mouth: An Update for the General Medical Practitioner

Leão

Gomes

Porter

2007

Clinics

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Leão JC, Gomes VB, Porter S. Ulcerative lesions of the mouth: an update for the general medical practitioner. Clinics. 2007;62(6):769-80.Oral ulceration is a common complaint of patients attending out-patient clinics. Because of the diversity in causes of oral ulceration, patients presenting with oral mucosal disease can be challenging to diagnose and manage. Patients with signs or symptoms of oral ulcers are sometimes referred to gastroenterology clinics; however, in most instances the ulcers do not result from gastrointestinal disease. The aim of the present article is to review aspects of the etiology, diagnosis and management of common ulcerative disorders of the oral mucosa. A search in the National Library of Medicine computerized bibliographic database MEDLINE was performed. Selection of publications, extraction of data, and validity assessment were then performed by the authors. Based upon the searched literature, it is concluded that there are several systemic disorders that can present with similar clinical signs and symptoms, and knowledge of each disease is necessary for the clinician to provide proper management.

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“…A variety of vascular lesions, such as small-vessel vasculitis and large venous or arterial lesions, can develop, and venous lesions including superficial thrombophlebitis and deep vein thrombosis (DVT) are characteristic manifestations of the disease [4,5,11,12]. Although the exact pathogenesis for BD is not completely understood, it has been suggested that the disease is triggered in genetically susceptible individuals by environmental factors, such as infectious agents [4,5,[12][13][14][15]. Recent studies have strengthened the significance of genetic factors in the pathogenesis of the disease.…”

mentioning

confidence: 99%

Update on the Molecular Genetic Studies of Behcets Disease

Chang

2005

CRR

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Although the pathogenesis of Behcet's disease (BD) is not fully elucidated, a genetic susceptibility to the disease appears to be affected by a polygenic inheritance, including the major histocompatibility complex (MHC) and non-MHC genes. As is true for the well-known regional differences in the disease expression of BD, a genetic susceptibility to BD appears to be different in various ethnic groups. Although HLA-B51 is a genetic factor with the strongest association in most ethnic populations who reside in countries adjacent to the ancient Silk Road, it is still uncertain whether this HLA molecule is directly involved in the pathogenesis of BD. In addition to HLA-B51, the association of BD with the MICA gene has been reported to be the consequence of linkage disequilibrium with HLA-B51, whereas the TNF-1031C allele among TNF gene polymorphisms has been observed to be another risk factor independent of the presence of HLA-B51 in UK Caucasoid patients with BD. Recently, intensive investigations on non-MHC genes, some of which are noted to be associated with a susceptibility to BD in several ethnic groups, are under way.

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New insights into the pathogenesis and therapy of Behçet's disease

Cited by 45 publications

References 42 publications

Cytokines in Autoimmune Uveitis

Cytokines in Autoimmune Uveitis

Ulcerative Lesions of the Mouth: An Update for the General Medical Practitioner

Update on the Molecular Genetic Studies of Behcets Disease

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