New insights into the pathogenesis of systemic sclerosis

Tamby, Mathieu C.; Chanseaud, Youri; Guillevin, Loı̈c; Mouthon, Luc

doi:10.1016/s1568-9972(03)00004-1

Cited by 142 publications

(98 citation statements)

References 37 publications

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“…The onset and development of SSc requires complicated crosstalk among multiple biologic pathways, involving inflammatory cytokines, chemokines and their receptors, and growth factors (1,(6)(7)(8)(9). For example, proinflammatory cytokines, such as IL-1, IL-2, interferon-␥, and tumor necrosis factor ␣ (TNF␣), can induce the production of chemokines (23).…”

Section: Discussionmentioning

confidence: 99%

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

Lee¹,

Zhao²,

Kim³

et al. 2007

Arthritis & Rheumatism

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Objective. To examine genetic polymorphisms in the chemokine pathway, and to assess their interactions in relation to susceptibility to systemic sclerosis (SSc).Methods. To identify the risk of SSc conferred by genetic polymorphisms in the chemokine pathway, 10 single-nucleotide polymorphisms (SNPs) from 8 candidate genes were studied in 99 patients with SSc and 198 age-and sex-matched controls in a Korean population. SNPs were genotyped by polymerase chain reactionrestriction fragment length polymorphism or sequencespecific primer methods. Genetic associations between each SNP and SSc risk, calculated as odds ratios with 95% confidence intervals, were estimated using chisquare tests. Haplotypes for the 2 polymorphisms in the gene CCL5 (RANTES) were constructed, and their associations with SSc were tested. Gene-gene interactions were investigated using a recently described novel method, and the results were confirmed by conditional logistic regression. Adjustment for multiple testing was based on Bonferroni correction.Results. There was significant evidence of genegene interaction between polymorphisms in the genes CXCL8 (interleukin-8) and CCL5, and both of these were associated with an increased risk of SSc. This SNP-SNP interaction was confirmed by 2 independent statistical methods. The associations remained significant after Bonferroni adjustment for multiple testing. No significant association between each individual SNP or haplotype and the risk of SSc was found.Conclusion. Crosstalk between the 2 chemokines CXCL8 and CCL5 may contribute to the susceptibility to SSc.

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Section: Discussionmentioning

confidence: 99%

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

Lee¹,

Zhao²,

Kim³

et al. 2007

Arthritis & Rheumatism

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“…Lung fibroblasts play a central role as they are activated and produce extracellular matrix as well as many of the many of the inflammatory and fibrotic mediators [8]. This inflammatory response leads to fibrosis and occurs in the setting of vascular derangements [9].…”

Section: Lung Fibrosis In Sclerodermamentioning

confidence: 99%

Interstitial Lung Disease in Systemic Sclerosis: Diagnosis and Management

Schol

Carr²,

Frech³

et al. 2012

Rheumatology

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“…Systemic sclerosis (SSc; scleroderma) is a connective tissue disease characterized by an autoimmune reaction with specific autoantibodies, excessive collagen deposition, and vascular hyperreactivity and obliterative microvascular phenomena (1)(2)(3)(4). The American College of Rheumatology classification, developed to distinguish SSc from other connective tissue diseases, has provided a common definition of the disease (5).…”

Section: Introductionmentioning

confidence: 99%

Recommendations for the care of oral involvement in patients with systemic sclerosis

Alantar¹,

Cabané²,

Hachulla³

et al. 2011

Arthritis Care & Research

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Objective. To review the literature and collect expert advice for proposing preventive and curative treatments of mouth and dental involvement in patients with systemic sclerosis (SSc; scleroderma). Methods. The literature pertaining to mouth and/or dental involvement related to SSc was reviewed, and recommendations were developed according to the suggestions of a French multidisciplinary working group of experts and validated by a lecture committee. Results. Dentists face 3 main issues in caring for SSc patients: oral mucosa involvement, manducatory apparatus and mouth involvement responsible for limitations in mouth opening, and treatment-related adverse events. An increased risk of tongue carcinoma has been noted. In patients with severe limitation in mouth opening (<30 mm), recommended treatments are a specific mouth-opening rehabilitation program, flexible sectional dentures, and splint therapy. Indications for dental implants depend on the severity of SSc, comorbidities, and/or ongoing bisphosphonate treatment. Prevention of mouth infections and caries implies patient education and teaching about mouth and dental hygiene, periodontal maintenance, and treatment of sicca syndrome. Cessation of tobacco use is mandatory. Patient-tailored rehabilitation may improve limitations in mouth opening. Systematic dental panoramic radiography allows for the early detection of dental caries. Conclusion. Prevention of oral and dental complications is a major issue in patients with SSc. Dental treatment should be tailored to limitations in mouth opening, disease severity, and ongoing treatments.

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New insights into the pathogenesis of systemic sclerosis

Cited by 142 publications

References 37 publications

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

Interstitial Lung Disease in Systemic Sclerosis: Diagnosis and Management

Recommendations for the care of oral involvement in patients with systemic sclerosis

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