New insights into the organization of a gastroduodenal inhibitory reflex by the coeliac plexus

Mazet, Bruno; Miolan, J.P.; Niel, Jean-Pierre; Roman, C

doi:10.1016/0165-1838(94)90150-3

Cited by 20 publications

(25 citation statements)

References 31 publications

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“…Experiments of the last twenty years disclosed new complex function of these ganglia and nowadays prevertebral ganglia are considered to be an independent, autonomic nerve structures that are responsible for complex inter-and intra-organ regulations. Moreover, studies conducted in vivo have revealed that the celiac ganglion plays a crucial role in inhibitory reflex existing between the stomach and the duodenum (Mazet et al, 1994) as well as constitutes a connection between the central and peripheral nervous system (Simmons, 1985).…”

Section: Distribution Of Traced Neuronsmentioning

confidence: 99%

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Załęcki

2012

Journal of Chemical Neuroanatomy

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Section: Distribution Of Traced Neuronsmentioning

confidence: 99%

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Załęcki

2012

Journal of Chemical Neuroanatomy

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“…It is well known that prevertebral ganglionic neurones and visceral afferents fire Na¤ action potentials, as their spiking activity is abolished by tetrodotoxin or Na¤-free solution. However, these fibres also have the property of organizing at the prevertebral level, and without action potentials (Mazet et al 1993b), the gastroduodenal inhibitory reflex analysed in the present paper. Taken together, these results suggest that visceral afferents and prevertebral neurones have two levels of activity, one involving the genesis of action potentials and probably involved in fast regulation, and the…”

Section: Functional Implicationsmentioning

confidence: 97%

“…adjacent compartments: one received the viscera (stomach and duodenum), and the other the coeliac plexus (Mazet et al 1989(Mazet et al , 1993b. These compartments could be perfused separately with drugs.…”

Section: Methods Experimental Animals and In Vitro Preparationmentioning

confidence: 99%

“…In a previous study, we have shown that the gastrointestinal inhibitory reflex is organized by the coeliac plexus without action potentials along the afferent and efferent fibres (Mazet et al 1993b). Moreover, the delay between gastric distension and the occurrence of intestinal inhibition (range, 1-10 min; mean, 3·6 ± 0·3 min) excludes any modification of axonal transport along these fibres in the genesis of this reflex.…”

Section: Characteristics Of the Gastroduodenal Inhibitory Reflexmentioning

confidence: 99%

“…Inhibitory gastrointestinal reflexes organized by the coeliac plexus have also been demonstrated in in vitro models consisting of isolated stomach and duodenum connected only to the coeliac plexus by nervous rami (Kreulen et al 1983;Mazet et al 1993b). In a previous study (Mazet et al 1993b), we demonstrated that a delayed and long-lasting gastrointestinal inhibitory reflex was organized by the coeliac plexus. This nervous Release of nitric oxide within the coeliac plexus is involved in the organization of a gastroduodenal inhibitory reflex in the rabbit 1.…”

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confidence: 99%

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Release of nitric oxide within the coeliac plexus is involved in the organization of a gastroduodenal inhibitory reflex in the rabbit

Quinson

Catalin

Niel

et al. 1999

The Journal of Physiology

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The autonomic nervous system is involved in the regulation of visceral function, including the regulation of digestive tract motility. One characteristic of this system is that the nervous regulatory structures are not localized exclusively in the cerebrospinal axis. From a classic point of view, it could be described as having an intrinsic level of regulation located in the viscera and an extrinsic level of regulation in the prevertebral ganglia and central nervous structures, with each level of regulation having its own integrative properties. The prevertebral ganglia, which are part of the sympathetic system, have long been considered as a simple relay on the efferent central pathway. During the last 20 years, numerous studies devoted to the prevertebral ganglia have shown that they behave as true integrative nervous structures able to organize intra-and interorgan regulation.Experiments performed on in vitro preparations consisting of prevertebral ganglia connected to part of the digestive tract have revealed the involvement of these ganglia in the organization of gastrointestinal reflexes. Kreulen & Szurszewski (1979) showed that an inhibitory reflex occurred between two segments of the colon connected only via the coeliac ganglion and the inferior mesenteric ganglion by the mesenteric nerves. This reflex disappeared after sectioning of the intermesenteric nerves. Inhibitory gastrointestinal reflexes organized by the coeliac plexus have also been demonstrated in in vitro models consisting of isolated stomach and duodenum connected only to the coeliac plexus by nervous rami (Kreulen et al. 1983;Mazet et al. 1993b). In a previous study (Mazet et al. 1993b), we demonstrated that a delayed and long-lasting gastrointestinal inhibitory reflex was organized by the coeliac plexus. This nervous Journal of Physiology (1999) 1. The coeliac plexus can organize a gastroduodenal inhibitory reflex without action potentials. The involvement of the nitric oxide-cGMP pathway in this reflex was investigated in the rabbit on an in vitro preparation of the coeliac plexus connected to the stomach and duodenum. Intraluminal duodenal pressures were measured with water-filled balloons. Gastric distension inhibited duodenal motility, thus characterizing a gastroduodenal inhibitory reflex organized by the coeliac plexus. 2. ¬_Arginine, superfused at the coeliac plexus level, enhanced this reflex, whereas N ù -nitro¬_arginine (¬-NOARG) or 2-(4-carboxyphenyl)-4,4,5,5tetramethylimidazoline-1-oxyl-3-oxide (carboxyPTIO) reduced or abolished it. Moreover, diethylamineÏnitric oxide complex superfused at the coeliac plexus level inhibited duodenal motility in the absence of gastric distension. 3. The effects of nitric oxide were mediated through the activation of guanylyl cyclase, as 1H_[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) reduced or abolished the gastroduodenal inhibitory reflex, whereas zaprinast enhanced it. Moreover, 8-bromo-cGMP and cGMP, superfused at the coeliac plexus level, inhibited duodenal motility in the absence of gas...

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Gastric Motility and Gastric Emptying

Camilleri

2015

Yamada' S Textbook of Gastroenterology

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New insights into the organization of a gastroduodenal inhibitory reflex by the coeliac plexus

Cited by 20 publications

References 31 publications

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Release of nitric oxide within the coeliac plexus is involved in the organization of a gastroduodenal inhibitory reflex in the rabbit

Gastric Motility and Gastric Emptying

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