New insights into the molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease
Luis Antonio Diaz,
Gerald Scott Winder,
Lorenzo Leggio
et al.
Abstract:Alcohol use disorder (AUD) remains a significant public health concern, affecting around 5% of adults worldwide. Novel pathways of damage have been described during the last years, providing insight into the mechanism of injury due to alcohol misuse beyond the direct effect of ethanol byproducts on the liver parenchyma and neurobehavioral mechanisms. Thus, the gut-liver-brain axis and immune system involvement could be therapeutic targets for AUD. In particular, a change in gut microbiota composition and funct… Show more
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