New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases

Chen, Jiali; Xiao, Yuhang; Li, Dongmei; Zhang, Shiqing; Wu, Yingzi; Zhang, Qing; Bai, Weibin

doi:10.1002/imt2.69

Cited by 41 publications

(23 citation statements)

References 139 publications

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“…[ 66 ] Bile acids, short‐chain fatty acids, and trimethylamine N‐oxide are the common substances in high‐fat diet (HFD)‐induced chronic diseases. [ 67 ] Our data found that proline‐hydroxyproline, and L‐glutamic acid were upregulated while prostaglandin h2 and dinoprostone were downregulated in PDMAPS/GelMA‐ECM, compared with PAC/GelMA‐ECM (Figure 7F,H–K, Figure S8B,D–G, Supporting Information). And threonine, leucine, and isoleucine were upregulated, while arachidonic acid, prostaglandin h2, and dinoprostone were downregulated in PDMAPS/GelMA‐ECM compared with PDAC/GelMA‐ECM.…”

Section: Resultsmentioning

confidence: 84%

Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration

Li,

Yue,

Peng

et al. 2023

Adv Funct Materials

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Zwitterionic materials containing both cationic and anionic ligands have been reported to promote hydroxyapaptite (HA)‐mineralization. However, how zwitterionic microenvironment regulates osteogenesis of bone marrow mesenchymal stem cells (BMSCs) and bone regeneration remains elusive. Here, a strategy using zwitterionic (2‐(N‐3‐sulfopropyl‐N, N‐dimethyl ammonium) ethyl methacrylate/ Methacrylated gelatin (DMAPS/GelMA) hydrogel to promote osteogenic differentiation of BMSCs in vitro and enhance bone defect repair in vivo is developed. This zwitterionic hydrogel exhibits high stereo‐affinity of fibronectin III7‐10 (FnIII7‐10) and accelerates endogenous stem cell recruitment during bone regeneration. Then, the metabolic architecture of zwitterion‐guided osteogenesis is explored by using precise untargeted metabolomics, and the metabolic profile is mapped in the zwitterionic microenvironment. The zwitterion‐dependent energetic metabolic profile reveals that amino acids capable of promoting osteogenesis, such as proline and hydroxyproline, are enriched in zwitterionic extracellular matrix (ECM); whereas, fatty acids suggestting the inflammatory response, such as dinoprostone and prostaglandin h2, are enriched in either positive‐charged ECM or negative‐charged ECM. This zwitterionic ECM‐dependent metabolic landscape is the underlying mechanism of zwitterionic hydrogel‐promoted osteogenic differentiation of BMSCs. Therefore, the study provides a deeper contextual understanding of zwitterionic‐directed bone regeneration, leading to stereochemical principles of valuable functionalized biomaterial design.

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Section: Resultsmentioning

confidence: 84%

Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration

Li,

Yue,

Peng

et al. 2023

Adv Funct Materials

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“…They reside on intestinal epithelial barriers and are symbiotic with the host. The complex microbial ecosystem is crucial in human health, and disruption of which is associated with chronic inflammation, auto‐immune diseases, heart failure, and even cancer [8, 9] (Figure 2). Previous studies have indicated commensal microbiota plays contrasting roles in cancer initiation, progression, and metastasis.…”

Section: The Cancer‐microbiota‐immune Axismentioning

confidence: 99%

Gut microbiota reshapes cancer immunotherapy efficacy: Mechanisms and therapeutic strategies

Xie,

Liu,

Deng

et al. 2024

iMeta

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Gut microbiota is essential for maintaining local and systemic immune homeostasis in the presence of bacterial challenges. It has been demonstrated that microbiota play contrasting roles in cancer development as well as anticancer immunity. Cancer immunotherapy, a novel anticancer therapy that relies on the stimulation of host immunity, has suffered from a low responding rate and incidence of severe immune‐related adverse events (irAEs). Previous studies have demonstrated that the diversity and composition of gut microbiota were associated with the heterogeneity of therapeutic effects. Therefore, alteration in microbiota taxa can lead to improved clinical outcomes in immunotherapy. In this review, we determine whether microbiota composition or microbiota‐derived metabolites are linked to responses to immunotherapy and irAEs. Moreover, we discuss various approaches to improve immunotherapy efficacy or reduce toxicities by modulating microbiota composition.

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“…It is worth noting that the intervention of dietary components on the gut microbiota and its metabolites, which in turn affects the progression of obesity and its complications, has been well established not only through in vitro and animal experiments but also through a multitude of clinical trials (Chambers et al., 2019; Chen et al., 2023; García‐Mantrana et al., 2018). For example, a randomized crossover trial demonstrated that dietary supplementation with inulin improved insulin sensitivity among overweight and obese adults, accompanied by distinctive alterations in both the composition of the gut microbiota and systemic inflammatory responses (Chambers et al., 2019).…”

Section: Effect Of Dp On Obesity and Its Multiple Complications Revea...mentioning

confidence: 99%

Macro insights into the shared and distinct regulations of dietary polysaccharides on gut microbiota and their roles in obesity

Xie,

Huang,

Cai

et al. 2023

Food Safety and Health

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Obesity has emerged as a global health epidemic, demanding a comprehensive understanding of its etiology and potential interventions. Recent studies have highlighted the crucial role of gut microbiota in maintaining host health. Additionally, dietary polysaccharides (DP), such as pectic polysaccharides, sulfated polysaccharides, glucan‐like polysaccharides, and fructan‐like polysaccharides, have been identified as crucial regulators that influence gut microbial composition, function, and metabolite production, thereby improving obesity and mitigating its complications. This review comprehensively summarizes the latest findings regarding the sources and structural characteristics of different DP, their shared and distinct effects on gut microbiota and associated metabolites, and the consequent influence on obesity and its complications. By unraveling the complex interplay among DP, gut microbiota, and obesity‐related outcomes, we strive to offer valuable insights that can inform the development of precise dietary interventions and therapeutic strategies aimed at tackling obesity and enhancing public health.

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New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases

Cited by 41 publications

References 139 publications

Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration

Metabolic Response Modulations by Zwitterionic Hydrogels for Achieving Promoted Bone Regeneration

Gut microbiota reshapes cancer immunotherapy efficacy: Mechanisms and therapeutic strategies

Macro insights into the shared and distinct regulations of dietary polysaccharides on gut microbiota and their roles in obesity

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