New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Khair, Shanawaj; Brenner, Lisa A.; Koval, Michael; Samuelson, Derrick R.; Cucinello-Regland, Jessica A.; Anton, Paige; Piano, Mariann R.; Simon, Liz; Crotty, Kathryn; Sharieh, Farah; Travers, Jeffrey B.; Singh, Vaibhav; Cannon, Abigail R.; Kim, Adam; McCullough, Rebecca L.; Yeligar, Samantha M.; Wyatt, Todd A.; McMahan, Rachel H.; Choudhry, Mashkoor A.; Kovacs, Elizabeth J.

doi:10.1016/j.alcohol.2022.05.004

Cited by 3 publications

(1 citation statement)

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“…Alcohol misuse associated with burn or trauma injury has been extensively researched and is associated with increased complications including lung inflammation, injury and death and susceptibility to infection and AUD patients require more resuscitation and have a longer hospital stay (Khair et al, 2022; Silver et al, 2008; Yeligar et al, 2016). Alcohol exacerbates posttrauma or burn levels of inflammatory cytokines especially IL‐1β, IL‐6 and TNF‐α production by monocytes and other immune cells (Luck et al, 2021; Szabo & Saha, 2015).…”

Section: Alcohol Abuse As An Established Risk Factor For Sars Severit...mentioning

confidence: 99%

Alcohol use disorder as a potential risk factor forCOVID‐19 severity: A narrative review

Forsyth

Voigt

Swanson

et al. 2022

Alcoholism Clin & Exp Res

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In Dec. 2019‐January 2020, a pneumonia illness originating in Wuhan, China, designated as coronavirus disease 2019 (COVID‐19) was shown to be caused by a novel RNA coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). People with advanced age, male sex, and/or underlying health conditions (obesity, type 2 diabetes, cardiovascular disease, hypertension, chronic kidney disease, and chronic lung disease) are especially vulnerable to severe COVID‐19 symptoms and death. These risk factors impact the immune system and are also associated with poor health, chronic illness, and shortened longevity. However, a large percent of patients without these known risk factors also develops severe COVID‐19 disease that can result in death. Thus, there must exist risk factors that promote exaggerated inflammatory and immune response to the SARS‐CoV‐2 virus leading to death. One such risk factor may be alcohol misuse and alcohol use disorder because these can exacerbate viral lung infections like SARS, influenza, and pneumonia. Thus, it is highly plausible that alcohol misuse is a risk factor for either increased infection rate when individuals are exposed to SARS‐CoV‐2 virus and/or more severe COVID‐19 in infected patients. Alcohol use is a well‐known risk factor for lung diseases and ARDS in SARS patients. We propose that alcohol has three key pathogenic elements in common with other COVID‐19 severity risk factors: namely, inflammatory microbiota dysbiosis, leaky gut, and systemic activation of the NLRP3 inflammasome. We also propose that these three elements represent targets for therapy for severe COVID‐19.

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