2017
DOI: 10.3389/fendo.2017.00323
|View full text |Cite
|
Sign up to set email alerts
|

New Insights into the Mechanism of Action of Soluble Klotho

Abstract: The klotho gene encodes a type I single-pass transmembrane protein that contains a large extracellular domain, a membrane spanning segment, and a short intracellular domain. Klotho protein exists in several forms including the full-length membrane form (mKl) and a soluble circulating form [soluble klotho (sKl)]. mKl complexes with fibroblast growth factor receptors to form coreceptors for FGF23, which allows it to participate in FGF23-mediated signal transduction and regulation of phosphate and calcium homeost… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
127
1
5

Year Published

2019
2019
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 155 publications
(135 citation statements)
references
References 129 publications
(168 reference statements)
2
127
1
5
Order By: Relevance
“…This hypothesis is consistent with the fact that Klotho orthologs in Caenorhabditis elegans encode only KL1 domain-like proteins that inhibit DAF-2, which is homologous to IGF-1 signaling in mammals (13). Additional studies found that sKL inhibits TNF-α, IGF-1, Wnt, and TGF-β signaling (1,(14)(15)(16)(17)(18). In addition, sKL is proposed to bind to gangliosides containing α-2-3-sialyllactose in lipid rafts to inhibit PI3K signaling (19), as well as regulate calcium-permeable transient receptor potential canonical type isoform 6 (TRPC6) channels (20).…”
Section: Introductionsupporting
confidence: 80%
“…This hypothesis is consistent with the fact that Klotho orthologs in Caenorhabditis elegans encode only KL1 domain-like proteins that inhibit DAF-2, which is homologous to IGF-1 signaling in mammals (13). Additional studies found that sKL inhibits TNF-α, IGF-1, Wnt, and TGF-β signaling (1,(14)(15)(16)(17)(18). In addition, sKL is proposed to bind to gangliosides containing α-2-3-sialyllactose in lipid rafts to inhibit PI3K signaling (19), as well as regulate calcium-permeable transient receptor potential canonical type isoform 6 (TRPC6) channels (20).…”
Section: Introductionsupporting
confidence: 80%
“…Klotho was originally identified as an aging suppressor gene that includes α-, β-, and γ-Klotho based on their predicted primary sequences [4]. Among these variants, α-Klotho has been widely studied in the kidney and heart and their related complications.…”
Section: Introductionmentioning
confidence: 99%
“…Klotho is a membrane protein, and a soluble form of this protein is identified in the blood, cerebral fluid and urine, presumably exhibiting pleiotropic actions [55]. Klotho was originally identified as an anti-aging protein mainly expressed in renal tubule epithelial cells [56].…”
Section: Discussionmentioning
confidence: 99%