New insights into the function of melatonin and its role in metabolic disturbances

Amaral, Fernanda Gaspar do; Andrade-Silva, Jéssica; Kuwabara, Wilson Mitsuo Tatagiba; Cipolla‐Neto, José

doi:10.1080/17446651.2019.1631158

Cited by 48 publications

(45 citation statements)

References 96 publications

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“…The beneficial effects of perinatal melatonin administration are attributed to several mechanisms that are known to interrelate with the pleiotropic functions of melatonin, but on the other hand, these biofunctions might cause negative effects. Maternal melatonin is able to cross the placenta and enter the fetal circulation, this being another form of action which is called the transgenerational effect [111]. Considering this, additional studies are needed to clarify whether there is any negative consequence caused by its perinatal use on their offspring.…”

Section: Resultsmentioning

confidence: 99%

Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases

Hsu

Huang

Tain

2019

IJMS

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Cardiovascular and neurological diseases can originate in early life. Melatonin, a biologically active substance, acts as a pleiotropic hormone essential for pregnancy and fetal development. Maternal melatonin can easily pass the placenta and provide photoperiodic signals to the fetus. Though melatonin uses in pregnant or lactating women have not yet been recommended, there is a growing body of evidence from animal studies in support of melatonin as a reprogramming strategy to prevent the developmental programming of cardiovascular and neurological diseases. Here, we review several key themes in melatonin use in pregnancy and lactation within offspring health and disease. We have particularly focused on the following areas: the pathophysiological roles of melatonin in pregnancy, lactation, and fetal development; clinical uses of melatonin in fetal and neonatal diseases; experimental evidence supporting melatonin as a reprogramming therapy to prevent cardiovascular and neurological diseases; and reprogramming mechanisms of melatonin within developmental programming. The targeting of melatonin uses in pregnancy and lactation will be valuable in the prevention of various adult chronic diseases in later life, and especially cardiovascular and neurological diseases.

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Section: Resultsmentioning

confidence: 99%

Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases

Hsu

Huang

Tain

2019

IJMS

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“…Результати експериментальних і клінічних наукових досліджень довели, що введення екзогенного МТ призводить до зниження осмолярності сечі, концентрації іонів натрію, калію, збільшенню швидкості клубочкової фільтрації (ШКФ). Адже під впливом МТ відбувається зменшення пошкодження паренхіматозних клітин та фіброзу, простежується зниження рівня протеїнурії [12][13][14][15]. Проте на сьогодні існує багато невирішених питань щодо особливостей синтезу МТ у хворих на гемодіалізі (ГД) залежно від часу добу, причини ХХН, тривалості гемодіалізу, віку та статі пацієнтів, що безсумнівно, потребує подальшого дослідження та обговорення.…”

Section: петрова аннаunclassified

Characteristics of melatonin-forming disorders of the epiphysis in hemodialysis patients depending on clinical and demographic parameters

Кondratiuk¹,

Petrová²

2020

Ukr. J. Nephrol. and Dial.

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Український журнал нефрології та діалізу №1 (65) 2020Ukrainian Journal of Nephrology and Dialysis, 1 (65)'2020 Оригінальні наукові роботи Original PapersAbstract. Current scientific studies' results have shown the relationship between the epiphysis functional state and the kidneys function. However, the impaired of the epiphysis melatonin-forming function (MFE) in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) is a poorly understood issue.Methods. 130 HD patients (50% of men) were examined in this study. Based on the melatonin level, the patients were allocated into 2 groups: group I included 110 HD patients with impaired MFE and group II consisted of 20 HD patients with preserved MFE. 20 healthy individuals were included in the control group.Results. The melatonin level was significantly lower in HD patients compared to the control group at daytime and night (p <0.001). MFE disorder were diagnosed in 84.6% HD patients. The group I patients had significantly higher BMI (p = 0.01), waist volume (p = 0.04), duration of HD treatment (p = 0.01) and arterial pressure (p <0.001) compared with the second group. Moreover, the increased level of C-reactive protein (p <0.001), total cholesterol (p < 0.05), triglycerides (p <0.05) and a lower serum albumin level (p <0.01) were observed in the patients of group I compared with the second one. The melatonin levels at daytime and night were significantly correlated with the patients' age p <0.001), p <0.001), p <0.001). In addition, albumin, hemoglobin and serum uric acid concentration were associated with the melatonin level.Conclusions. The violation of MFE was diagnosed in 84.6% of HD patients and determined by the duration of the dialysis treatment, the blood pressure, body weight, hemoglobin level, the degree of impaired protein and purine metabolism.

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“…Thus, melatonin sensitizes central and peripheral insulin action. The absence or reduction of pineal melatonin production, whether by the effect of light, aging or pinealectomy, could lead to insulin resistance and this resistance could be reversed by melatonin replacement (5,6). On the other hand, type 1 diabetes, either in humans or experimentally in animals can cause an accentuated reduction in melatonin synthesis (7).…”

Section: Introductionmentioning

confidence: 99%

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

et al. 2021

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The pineal gland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes. Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different aged male and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.

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New insights into the function of melatonin and its role in metabolic disturbances

Cited by 48 publications

References 96 publications

Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases

Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases

Characteristics of melatonin-forming disorders of the epiphysis in hemodialysis patients depending on clinical and demographic parameters

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

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