New insights into the dual recruitment of IgA+ B cells in the developing mammary gland

Bourges, Dorothée; Meurens, François; Berri, Mustapha; Chevaleyre, Claire; Zanello, Galliano; Levast, Benoît; Melo, Sandrine; Gerdts, Volker; Salmon, Henri

doi:10.1016/j.molimm.2008.04.017

Cited by 53 publications

(66 citation statements)

References 48 publications

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“…During pregnancy, immune cells are thought to be involved in regulating epithelial cell rearrangement and differentiation characteristic of the developing alveolar structures (26). This is followed by lactation during which immunoglobulin-secreting cells migrate to the mammary gland, releasing factors into the milk that are critical for immunity in the newborn (27, 28). Finally, macrophages are prominent in the environment of the involuting mammary gland and recent studies have linked macrophages to stromal rearrangements during this stage (29, 30).…”

Section: Immune Cells Associated With Post-natal Mammary Gland Develomentioning

confidence: 99%

Immune Cell Location and Function During Post-Natal Mammary Gland Development

Reed

Schwertfeger

2010

J Mammary Gland Biol Neoplasia

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Post-natal mammary gland development requires complex interactions between the epithelial cells and various cell types within the stroma. Recent studies have illustrated the importance of immune cells and their mediators during the various stages of mammary gland development. However, the mechanisms by which these immune cells functionally contribute to mammary gland development are only beginning to be understood. This review provides an overview of the localization of immune cells within the mammary gland during the various stages of post-natal mammary gland development. Furthermore, recent studies are summarized that illustrate the mechanisms by which these cells are recruited to the mammary gland and their functional roles in mammary gland development.

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Section: Immune Cells Associated With Post-natal Mammary Gland Develomentioning

confidence: 99%

Immune Cell Location and Function During Post-Natal Mammary Gland Development

Reed

Schwertfeger

2010

J Mammary Gland Biol Neoplasia

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“…However, further studies should be performed to evaluate if the yeast can proceed as an "immunobiotic" by modulating adaptive immune factors to act in other mucosal sites than the gut as the bronchial or the uro-genital mucosa (Clancy, 2003). Another question is to identify if the yeast can activate adaptive immune factors involved in the entero-mammary link, conferring better protection to the newborn (Bourges et al, 2008). Indeed, it has been shown that the yeast can modulate the migratory behaviour of lymphocytes by modification of lymph node endothelial cell adhesiveness (Dalmasso et al, 2006a).…”

Section: Resultsmentioning

confidence: 99%

Saccharomyces boulardiieffects on gastrointestinal diseases

Zanello

Meurens²,

Berri³

et al. 2009

Current Issues in Molecular Biology

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Health benefits attributed to probiotics have been described for decades. They include the treatment and the prevention of gastrointestinal diseases, vaginal and urinary infections and allergies. Saccharomyces boulardii, a species of yeast widely distributed, has been described as a biotherapeutic agent since several clinical trials displayed its beneficial effects in the prevention and the treatment of intestinal infections and in the maintenance of inflammatory bowel disease. All these diseases are characterized by acute diarrhoea. Administration of the yeast in combination or not with an antibiotherapy has shown to decrease significantly the duration and the frequency of diarrhoea. Experimental studies elucidated partially the molecular mechanisms triggered to improve the host health. The discovery of its anti-inflammatory and immuno-modulatory activities in correlation with the advances in the understanding of mucosal immunology opens a new field of perspectives in S. boulardii therapeutic applications.

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“…Unfortunately, we could not shed light on the mechanism responsible for the suggested PRL modulation of T-cell homing to MG as no major changes in the mRNA expression of CCR1, CCR2, CCR7, CXCR3, and CXCR5 chemokine receptors were found. To support this notion, reports indicate that at least two adhesion molecules, MadCam and a4 b7, are involved in MG homing during pregnancy and lactation (Tanneau et al 1999, van der Feltz et al 2001, Nishimura 2003, Bourges et al 2008. The possibility cannot be excluded that additional changes may occur during T-cell recruitment and maintenance in MG, involving addressins, integrins, and chemokine receptors' expression on T cells as well as chemokine production by mammary epithelial cells under hormone/cytokine stimulation.…”

Section: Discussionmentioning

confidence: 99%

Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats

Mackern-Oberti¹,

Valdéz²,

Vargas–Roig³

et al. 2013

Reproduction

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Mammary stroma is composed of various cell types, including migratory leukocytes. Although mammary antibody-secreting cells have been extensively studied, reports focusing on mammary T cells are scarce. It is thought that the recruitment mechanism of leukocytes to the mammary gland (MG) is controlled by pregnancy-and lactation-specific stimuli. But whether prolactin (PRL) modulates the T-cell population in MG is still unknown. Our aim was to study the relationship between PRL levels and T and B cells during early lactation (L2, day 2 post partum) and mid-lactation (L12, day 12 of lactation). In order to investigate whether PRL is associated with homing events to MG, female Sprague Dawley (SD) and SD-derived desmoglein 4 K/K hairless (phenotype with lactation deficit, OFA hr/hr) rats were killed during estrus, pregnancy, and post partum, and blood, MG, and corpora lutea were obtained to perform fluorescent-activated cell sorting (FACS), real-time PCR, and histological and RIA studies. Serum PRL levels were lower in OFA hr/hr rats than in SD rats during early lactation. MG of OFA hr/hr rats showed less secretory material compared with SD rats. FACS analysis showed lower percentage of MG CD3C cells in OFA hr/hr rats compared with SD rats on L2 and L12. OFA hr/hr rats showed higher absolute numbers of circulating CD3C cells compared with SD rats on L2 but not on L12. These results show that T-cell population in MG is affected in early lactating OFA hr/hr rats and strongly suggest that serum PRL levels may be involved in the homing events to MG, probably helping antibody-secreting cells and protecting the gland during lactation development.

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New insights into the dual recruitment of IgA+ B cells in the developing mammary gland

Cited by 53 publications

References 48 publications

Immune Cell Location and Function During Post-Natal Mammary Gland Development

Immune Cell Location and Function During Post-Natal Mammary Gland Development

Saccharomyces boulardiieffects on gastrointestinal diseases

Impaired mammary gland T cell population during early lactation in hypoprolactinemic lactation-deficient rats

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