New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species

A Systematic Review on Phytochemistry, Ethnobotany and Biological Activities of the Genus Bunium L.

“…Turkey Quinic acid, salvianic acid A, pantothenic acid, esculin, kynurenic acid, chlorogenic acid, crypto-chlorogenic acid, naringenin-6.8-di-C-glucoside, 4-hydroxy-mellein, vicenin-2, indole-4-carbaldehyde, orientin, iso-orientin, vitexin, iso-vitexin, cynaroside, narirutin, iso-quercitrin, rutin, cosmosiin, diosmin, bergapten, naringenin, luteolin, kaempferol, apigenin, salcolin A, angelicin, salcolin B, imperatorin [l] Methanol HPLC/MS [69] B. paucifolium DC.…”

“…A perusal of the obtained results revealed that none of EO sample or the studied extracts resulted to be more effective with IC 50 values equal to 23.4, 45.7, 79.6 13 mmol TE/g. [69] The methanol/dichloromethane (1 : 1 v/v), ethyl acetate and butanol extracts of B. alpinum, as well as the isolated compound, i. e., iso-quercetin, were evaluated through the DPPH * assay. The best result was obtained by the butanol extract with an EC 50 value equal to 1.89 μg/mL, whereas the EC 50 value for one of the isolated and characterized flavonoid compounds, namely quercetin-3-O-β-glucoside was equal to 0.28 μg/mL.…”

“…B. pinnatifolium also exhibited the highest antibacterial effect against M. flavus and E. cloacae with MIC and MBC values equal to 0.56 and 0.75 mg/mL, respectively. [69] Using broth microdilution method, antibacterial activities of BPEO have been determined against a panel of six bacteria involving E. coli, P. aeruginosa, B. cereus, S. aureus, S. epidermidis and E. faecalis considering MIC and MBC values. [122] In this relation, the best MIC and MBC values, as 4.0 and 15.0 μL/mL, respectively, were observed against S. epidermidis which were comparable to those obtained by ciprofloxacin (MIC = 4.0 μg/mL; MBC = 12 μg/mL) as standard.…”

“…Again, for what concerns the growth inhibition zone values, they all were seen to increase with the concentration raising. [18] More recently, Zengin et al [69] showed that all the extracts were mostly less potent than the standard compounds. Nevertheless, in many cases, the values were highly comparable with those of the used standards and also very similar to each other except a few cases.…”

“…B. microcarpum extract was the best glucosidase inhibitor with a value equal to 11.96 mmol ACAE/g, whereas the best lipase inhibitor was B. brachyactis extract with a value equal to 95.74 mg OE/g. [69] 5.12. Mosquito-Deterrent Activity BPEO was tested for its mosquito-deterrent activity against Aedes aegypti.…”