New Insights into Roles of Tubulobulbar Complexes in Sperm Release and Turnover of Blood-Testis Barrier

Vogl, A. Wayne; Young, J'Nelle Sarah; Du, Min

doi:10.1016/b978-0-12-407697-6.00008-8

Cited by 67 publications

(69 citation statements)

References 82 publications

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“…For example, residual bodies are involved in the transport of Fe ++ and Fe ++ transport molecules released from mature germ cells at the apical seminiferous tubules, for utilization by the less mature meiotic germ cells located near the basal seminiferous tubule (65). In remodeling of the basal tight junctions, molecules have been shown to be recycled from the apical junctions of the Sertoli cell barrier in a process dependent on the endocytic uptake of the apical junction components into the ectoplasmic specialization of Sertoli cells (45,66,67). In addition, because the residual bodies We provided direct evidence for MGCA egress out of the seminiferous tubules by documenting the formation of immune complexes outside the Sertoli cell barrier following systemic LDH3 Ab transfer.…”

Section: Discussionmentioning

confidence: 99%

Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Tung

Harakal

Qiao

et al. 2017

Journal of Clinical Investigation

103

104

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Section: Discussionmentioning

confidence: 99%

Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Tung

Harakal

Qiao

et al. 2017

Journal of Clinical Investigation

103

104

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“…14,15 Sertoli cell actin-based microfilaments are abundant at 2 specialized testis-specific intercellular junctions. One of these junctions is the ectoplasmic specialization, 12,16 and the other is the tubulobulbar complex 17,18 (also see Cheng, this issue). Ectoplasmic specialization junctions occur at 2 locations: a basal location associated with tight junctions between adjacent Sertoli cells (blood-testis barrier) and an apical location between step 8 and more mature spermatids and Sertoli cells.…”

Section: Sertoli Cell Cytoskeleton Structure and Functionmentioning

confidence: 99%

Testicular histopathology associated with disruption of the Sertoli cell cytoskeleton

Johnson

2014

Spermatogenesis

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“…Soon after the commencement of spermiation, specialized structures called Tubulobulbar Complexes (TBCs) appear between the spermatid and the Sertoli cell, see 64,65 for recent review. These structures appear to be a modified form of endocytic machinery (Fig.…”

Section: An Overview Of Spermiationmentioning

confidence: 99%

Mechanisms of spermiogenesis and spermiation and how they are disturbed

2014

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Haploid round spermatids undergo a remarkable transformation during spermiogenesis. The nucleus polarizes to one side of the cell as the nucleus condenses and elongates, and the microtubule-based manchette sculpts the nucleus into its species-specific head shape. The assembly of the central component of the sperm flagellum, known as the axoneme, begins early in spermiogenesis, and is followed by the assembly of secondary structures needed for normal flagella. The final remodelling of the mature elongated spermatid occurs during spermiation, when the spermatids line up along the luminal edge, shed their residual cytoplasm and are ultimately released into the lumen. Defects in spermiogenesis and spermiation are manifested as low sperm number, abnormal sperm morphology and poor motility and are commonly observed during reproductive toxicant administration, as well as in genetically modified mouse models of male infertility. This chapter summarizes the major physiological processes and the most commonly observed defects in spermiogenesis and spermiation, to aid in the diagnosis of the potential mechanisms that could be perturbed by experimental manipulation such as reproductive toxicant administration. Signature LesionThere are a number of signature lesions that could indicate a disturbance in spermiogenesis or spermiation. These would include misshapen heads and/or tails of elongating/elongated spermatids. Multinucleated round spermatids may reflect disturbances in spermiogenesis, but could also reflect altered Sertoli cell function. Disruption of spermiation could present itself as spermatid retention at the lumen of post stage VIII tubules, failure of elongated spermatids to ascend to the lumen of stage VII/ VIII tubules, or phagocytosis of mature spermatids at the base of tubules in stages VII through to approximately XII (in mice) or XIV (in rats). The changes might occur in isolation or in combination with one another.

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New Insights into Roles of Tubulobulbar Complexes in Sperm Release and Turnover of Blood-Testis Barrier

Cited by 67 publications

References 82 publications

Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance

Testicular histopathology associated with disruption of the Sertoli cell cytoskeleton

Mechanisms of spermiogenesis and spermiation and how they are disturbed

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