New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data

Shaghaghi, Mohammadreza; Soleyman-Jahi, Saeed; Abolhassani, Hassan; Yazdani, Reza; Azizi, Gholamreza; Rezaei, Nima; Barbouche, Mohamed‐Ridha; McKinlay, Mark A.; Aghamohammadi, Asghar

doi:10.1016/j.vaccine.2018.02.059

Cited by 37 publications

(55 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Egypt, due to the absence of neonatal screening programs for PIDs, such patients often present to medical care after having received repeated OPV doses. Prolonged intestinal replication of OPV virus in PID patients can lead to development of vaccine-derived polioviruses (VDPV), which are referred to as immunodeficiency-related VDPV (iVDPV) [ 4 ]. VDPV excretors pose a threat to polio eradication efforts because they may continue to excrete and act as a reservoir in the community.…”

Section: Introductionmentioning

confidence: 99%

Poliovirus excretion following vaccination with live poliovirus vaccine in patients with primary immunodeficiency disorders: clinicians’ perspectives in the endgame plan for polio eradication

et al. 2018

View full text Add to dashboard Cite

ObjectivePrimary immunodeficiency (PID) patients are prone to developing viral infections and should not be vaccinated with live vaccines. In such patients, prolonged excretion and viral divergence may occur and they may subsequently act as reservoirs in the community introducing mutated virus and jeopardizing polio eradication. One hundred and thirty PID cases were included for poliovirus detection in stool with assessment of divergence of detected polioviruses from oral polio vaccine (OPV) virus. Clinical presentations of PID patients with detectable poliovirus in stool specimens are described.ResultsSix PID patients (4.5%) had detectable vaccine-derived poliovirus (VDPV) excretion in stool specimens; of these, five patients had severe combined immunodeficiency (two with acute flaccid paralysis, one with meningoencephalitis and two without neurological manifestations), and one patient had X-linked agammaglobulinemia (paralysis developed shortly after diagnosis of immunodeficiency). All six case-patients received trivalent OPV. Five case-patients had type 2 immunodeficiency-related vaccine-derived polioviruses (iVDPV2) excretion; one had concomitant excretion of Sabin like type 3 virus and one was identified as iVDPV1 excretor. Surveillance for poliovirus excretion among PID patients is critical as these patients represent a potential source to reseed polioviruses into populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Poliovirus excretion following vaccination with live poliovirus vaccine in patients with primary immunodeficiency disorders: clinicians’ perspectives in the endgame plan for polio eradication

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Asymptomatic iVDPV excretion in patients with CIDs has been reported particularly after the implementation of poliovirus screening program in recent years (34, 35). The patient in our study never had paralysis and his iVDPV infection was detected only by screening.…”

Section: Discussionmentioning

confidence: 99%

Natural Clearance of Prolonged VDPV Infection in a Child With Primary Immunodeficiency Disorder

et al. 2019

View full text Add to dashboard Cite

The emergence of immunodeficiency-associated vaccine-derived polioviruses (iVDPV) from children with primary immunodeficiency disorders poses a threat to the eradication program. Herein, we report a patient with severe combined immunodeficiency (SCID), identified as a prolonged serotype 3 iVDPV (iVDPV3) excreter with 13 VDPV3 isolates and a maximum of 10.33% nucleotide divergence, who abruptly cleared infection after a period of 2 years. Occurrence of an episode of norovirus diarrhea associated with increased activated oligoclonal cytotoxic T cells, inverse CD4:CD8 ratio, significantly elevated pro-inflammatory cytokines, and subsequent clearance of the poliovirus suggests a possible link between inflammatory diarrheal illness and clearance of iVDPV. Our findings suggest that in the absence of B cells and sufficiently activated T/NK cells, macrophages and other T cells may produce auto-inflammatory conditions by TLR/RLR ligands expressed by previous/ongoing bacterial or viral infections to clear VDPV infection. The study highlights the need to screen all the patients with combined immunodeficiency for poliovirus excretion and intermittent follow-up of their immune parameters if found positive, in order to manage the risk of iVDPV excretion in the polio eradication endgame strategy.

show abstract

“…Given the significant threat that picornaviruses pose to humans and animals, resulting in enormous economic damage to the livestock industry, development of picornavirus vaccines is of great significance. Although inactivated virus vaccines can offer effective prevention, there are associated residual risk issues, including incomplete virus inactivation and escape during the vaccine production process [82,83,84]. Therefore, genetically engineered vaccines are considered more suitable options to overcome these shortcomings of inactivated viral vaccines.…”

Section: Potential Applications Of Targeting the Picornaviral 2b Pmentioning

confidence: 99%

Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development

Zou

Jiang

et al. 2019

Viruses

View full text Add to dashboard Cite

Picornaviruses are associated with acute and chronic diseases. The clinical manifestations of infections are often mild, but infections may also lead to respiratory symptoms, gastroenteritis, myocarditis, meningitis, hepatitis, and poliomyelitis, with serious impacts on human health and economic losses in animal husbandry. Thus far, research on picornaviruses has mainly focused on structural proteins such as VP1, whereas the non-structural protein 2B, which plays vital roles in the life cycle of the viruses and exhibits a viroporin or viroporin-like activity, has been overlooked. Viroporins are viral proteins containing at least one amphipathic α-helical structure, which oligomerizes to form transmembrane hydrophilic pores. In this review, we mainly summarize recent research data on the viroporin or viroporin-like activity of 2B proteins, which affects the biological function of the membrane, regulates cell death, and affects the host immune response. Considering these mechanisms, the potential application of the 2B protein as a candidate target for antiviral drug development is discussed, along with research challenges and prospects toward realizing a novel treatment strategy for picornavirus infections.

show abstract

New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data

Cited by 37 publications

References 48 publications

Poliovirus excretion following vaccination with live poliovirus vaccine in patients with primary immunodeficiency disorders: clinicians’ perspectives in the endgame plan for polio eradication

Poliovirus excretion following vaccination with live poliovirus vaccine in patients with primary immunodeficiency disorders: clinicians’ perspectives in the endgame plan for polio eradication

Natural Clearance of Prolonged VDPV Infection in a Child With Primary Immunodeficiency Disorder

Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development

Contact Info

Product

Resources

About