New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

Yang, Hang; Biermann, Mona; Brauner, Jan Markus; Liu, Yi; Zhao, Yi; Herrmann, Martin

doi:10.3389/fimmu.2016.00302

Cited by 246 publications

(242 citation statements)

References 90 publications

(142 reference statements)

Supporting

Mentioning

221

Contrasting

Unclassified

Order By: Relevance

“…NETs are composed of DNA, histones and microbicidal peptides, with the ability to kill some bacterial species 15. The NETs immobilize and kill invading microorganisms to prevent their spreading.…”

Section: Discussionmentioning

confidence: 99%

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients

Costa

Gut

Azevedo

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

The objective of our study was to evaluate the association between peptidylarginine deiminase 4 (PAD4) concentration and its polymorphisms with mortality in patients with septic shock. We prospectively evaluated 175 patients aged over 18 years with septic shock upon intensive care unit (ICU) admission. However, 48 patients were excluded. Thus, 127 patients were enrolled in the study. At the time of the patients’ enrollment, demographic information was recorded. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentrations and its polymorphism PADI4_89 [rs11203366], PADI4_94 [rs2240340] and PADI4_104 [rs1748033]. The mean age was 63.3 ± 15.2 years, 56.7% were male, PAD4 concentration was 4.62 (2.48‐6.20) ng/mL and the ICU mortality rate was 67.7%. The patients who died in the ICU had higher APACHE II and Sequential Organ Failure Assessment (SOFA) scores. In addition, PAD4 concentration was higher in patients who died during ICU stay. However, there were no differences regarding PADI4 polymorphisms and ICU mortality. In the logistic regression models, PAD4 concentrations were associated with ICU mortality when adjusted for APACHE II score and lactate (OR: 1.477; CI 95%: 1.186‐1.839; P < .001), and when adjusted for age, gender and APACHE II score (OR: 1.392; CI 95%: 1.145‐1.692; P < .001). In conclusion, PAD4 concentration, but not PADI4_89, PADI4_94 and PADI4_104 polymorphisms, is associated with ICU mortality in septic shock patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients

Costa

Gut

Azevedo

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Necrotic and apoptotic cells release DNA into tissues [136] as well as activated neutrophils, that release chromatin in form of anti-microbial NETs (neutrophil extracellular traps) [137]. Generally, this self-DNA is rapidly degraded by tissue nucleases or ingested by scavenging phagocytes.…”

Section: Activation In Autoimmune Diseasesmentioning

confidence: 99%

Dendritic cell recruitment and activation in autoimmunity

Sozzani

Prete

Bosisio

2017

Journal of Autoimmunity

103

View full text Add to dashboard Cite

“…A third mechanism for the induction of NETs, recently reported, is through autophagy [9,10]. It is worth mentioning that neutrophils are not the only cells that form extracellular traps (ETs), and other immune cells, such as mast cells, eosinophils, and macrophages, can also …”

Section: Understanding the Process Of Nets Formationmentioning

confidence: 99%

Beneficial and Deleterious Effects of Neutrophil Extracellular Traps on Infection

Moreno-Altamirano¹,

Cruz-Gómez²,

López-Luis³

2017

Role of Neutrophils in Disease Pathogenesis

View full text Add to dashboard Cite

Polymorphonuclear neutrophils (PMNs) are the most abundant leukocytes in the blood and are considered as the irst line of innate immune defence against infectious diseases. However, PMN cells have a crucial function in both innate and adaptive immune responses.Neutrophils have several mechanisms to control pathogens, and one of them is their capability to form neutrophil extracellular traps (NETs) that may control infection. NETs have the capacity to trap microorganisms, kill them, or avoid their dissemination. The aim of this chapter is to provide a comprehensive review on NETs, the cells that produce them, and some of the mechanisms involved in their formation, their role in the immune response, and the pros and cons of NETs, focusing mainly on infectious diseases.

show abstract

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

Cited by 246 publications

References 90 publications

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients

Dendritic cell recruitment and activation in autoimmunity

Beneficial and Deleterious Effects of Neutrophil Extracellular Traps on Infection

Contact Info

Product

Resources

About