New insights into leukotrichia in nonsegmental vitiligo: A cross-sectional study

Mogawer, Rania M.; Elmasry, Maha Fathy; Mostafa, Wedad Z.

doi:10.4103/ijdvl.ijdvl_49_18

Cited by 7 publications

(5 citation statements)

References 2 publications

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“…This agrees with Kim et al [19] who reported that leukotrichia occurs in 8.9-45% of vitiligo cases. But this disagrees with Elmasry et al [20] who found, leukotrichia was found in 46.5% of their studied patients. This difference may be explained by different age, duration and activity among the patients.…”

Section: Discussioncontrasting

confidence: 73%

The Epithelial Cytokeratins 15 and 19 Gene Expression in Non-Segmental Vitiligo Patients under NB-UVB Phototherapy

2019

Benha Journal of Applied Sciences

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Cytokeratins15 and 19 were first suggested as a specific stem cell marker, demonstrated their restricted expression in the bulge region of murine and human hair follicles. It was proved that they are valuable tools to monitor tissue homeostasis and the potential to self-renew.The aim of this work was to investigate the expression of CK15 and CK19 as possible stem cell markers in the skin of vitiligo patients during NB-UVB phototherapy repigmentation. The current study was a case-control study that was conducted on 40 participants. Fifty of them were patients with vitiligo, and they were located in group 1. Group 2 contained 20 age and sex matched healthy control participants. Approval of the Local Ethics Committee on Research involving human subjects of Benha Faculty of Medicine and written informed consents of participants were obtained before samples collection. Quantitative assessment of cytokeratins 15& 19 gene expression in all biopsies by Real Time Polymerase Chain Reaction. the level of cytokeratins were found to be higher in the patients after they received NB-UVB than control and it was found a significant relation with the improvement of the disease.Cytokeratin 15&19 are valuable tools to monitor vitiligo improvement.

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Section: Discussioncontrasting

confidence: 73%

The Epithelial Cytokeratins 15 and 19 Gene Expression in Non-Segmental Vitiligo Patients under NB-UVB Phototherapy

2019

Benha Journal of Applied Sciences

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“…face and hands), on genitalia or with disseminated lesions. [33][34][35][36][37][38][39][40][41] However in contrast, in two studies vitiligo on visible locations did not interfere with HRQoL and there was no difference found between vitiligo patients with or without genital involvement. 42,43…”

Section: Qol Impairment In Patients With Different Locations Of Vitil...mentioning

confidence: 80%

“…Several studies reported worse HRQoL in patients with vitiligo located on visible sites (e.g. face and hands), on genitalia or with disseminated lesions 33–41 . However in contrast, in two studies vitiligo on visible locations did not interfere with HRQoL and there was no difference found between vitiligo patients with or without genital involvement 42,43 …”

Section: Resultsmentioning

confidence: 98%

Quality of life measurement in vitiligo. Position statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes with external experts

Chernyshov

Aragonés

Manolache³

et al. 2022

Acad Dermatol Venereol

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“…The incidence of scalp leukotrichia also was higher in generalized symmetrical vitiligo than in acrofacial vitiligo. The Vellus Score showed significant associations with Vitiligo Area and Severity Index [16].…”

Section: Discussionmentioning

confidence: 91%

“…Opinion can be drawn in the same line, mucosal involvement might be assumed to be a risk factor of developing extensive vitiligo They didn't put leucotrichia a prognostic sign, though the present study differed. Leucotrichia has been reported in 9-48.4% of the patients with vitiligo [16].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Some common clinical factors in extensive vitiligo- a case control study

Das¹,

Das²

2019

Int J Med Res Rev

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Introduction: Vitiligo is a common depigmenting disorder with profound stigma. Prevalence of vitiligo is 0.5% to 1%. Information about association of progressive vitiligo are well known. Prognostic factors of vitiligo also enlisted. However, little information is available on the risk factors for developing extensive vitiligo. Aims and Objectives: Aims of the study was to identify-factors which are associated with extensive vitiligo (involving more than 5% of the body surface area). The following risk factors were evaluated, Onset before 20 years of age, Duration of disease greater than 2 years, Presence of Koebner's phenomenon, Family history of vitiligo, Presence of leucotrichia and Mucosal involvement. Materials and Methods: A case control study were designed. Patients with Vitiligo > 5% body surface area involvement were classified as cases and <5% body surface area were labeled as controls. The frequency of evaluating associated clinical factors among the cases and controls were used to evaluate the extensive vitiligo's association with risk factors (disease risk associated exposure). Results: Two hundred and eleven patients were evaluated. The mean age at onset was 19.07+13.51 (+SD) years. Acrofacial vitiligo was the commonest type of vitiligo. Duration of disease more than 2 years, presence of Koebner's Phenomenon, Family history, Symmetry of lesions, milky white colour of lesion, presence of Leucotrichia, mucosal involvement and Acrofacial type vitiligo had statistically significant (p<.05) association with extensive vitiligo. Ratio of the odds of the outcomes in two groups was noted significant with Duration of disease more than 2 years, Koebner,s Phenomenon, Mucosal involvement and Leucotrichia. Conclusion: This case-control study has demonstrated a weak association between extensive vitiligo and duration of disease greater than 2 years. It has also indicated that koebner's phenomenon, mucosal involvement and leucotrichia are additional risk factors.

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New insights into leukotrichia in nonsegmental vitiligo: A cross-sectional study

Cited by 7 publications

References 2 publications

The Epithelial Cytokeratins 15 and 19 Gene Expression in Non-Segmental Vitiligo Patients under NB-UVB Phototherapy

The Epithelial Cytokeratins 15 and 19 Gene Expression in Non-Segmental Vitiligo Patients under NB-UVB Phototherapy

Quality of life measurement in vitiligo. Position statement of the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes with external experts

Evaluation of Some common clinical factors in extensive vitiligo- a case control study

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