“…Moreover, the closure of retinal vessels leads to areas with loss of blood flow within retina, which causes its chronic ischaemia and hypoxia and subsequent increase in the production of growth factors that, in turn, induce angiogenesis, formation of arterio-venous anastomoses and proliferation of fibrous tissue within retina and optic nerve disc (Yoshida et al, 2004;Curtis et al, 2009;Roy et al, 2010;Lange et al 2011). It is commonly accepted that hyperglycaemia plays crucial role in pathogenesis of diabetic angiopathy (Roy et al, 2010;Kowluru et al, 2010). Hyperglycaemia leads to the formation of advanced glycation end products (AGEs) which are durable, irreversible and their characteristic feature is to create cross-links between proteins which in turn affects flexibility of vessels (Wa et al, 2007;Roy et al, 2010;Yamagishi et al, 2011).…”