New insights into folliculotropic mycosis fungoides (FMF): A single-center experience

Hodak, Emmilia; Amitay‐Laish, Iris; Atzmony, Lihi; Prag-Naveh, Hadas; Yanichkin, Natalia; Barzilai, Aviv; Kershenovich, Ruben; Feinmesser, Meora

doi:10.1016/j.jaad.2016.03.009

Cited by 100 publications

(170 citation statements)

References 28 publications

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“…Infiltration of the epidermis and follicular mucinosis may be associated or not . Recently, two distinct patterns of clinicopathologic features have been described, with different prognostic outcomes . While many clinical and histopathological features have been reported, dermoscopic findings in FMF are largely unknown .…”

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confidence: 99%

Dermoscopic characterization of folliculotropic mycosis fungoides selectively localized on trunk and limbs

et al. 2019

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confidence: 99%

Dermoscopic characterization of folliculotropic mycosis fungoides selectively localized on trunk and limbs

et al. 2019

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“…However, recent data revealed a more complex relationship between folliculotropism and clinical outcomes. It has been suggested that there is a group of FMF patients for whom the disease is more indolent, and the prognosis is like that of classic MF [4,9] . A distinction can also be made between patients with advanced FMF and early FMF, with the latter having a favorable treatment response and prognosis [5] .…”

mentioning

confidence: 99%

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Giberson

Mourad²,

Gniadecki³

2017

Dermatology

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Background: Folliculotropic mycosis fungoides (FMF) is a distinct subtype of mycosis fungoides (MF) with unique clinicopathological features. The medical literature suggests that FMF has a more aggressive course and worse survival than classic MF. Previous studies do not use standardized treatment, and no studies have reported an association between treatment response and overall survival (OS). Objective: To compare OS for MF, FMF, and Sézary syndrome (SS) patients. Methods: Data were collected retrospectively from 218 patients (171 MF, 15 SS, 32 FMF) treated in a single academic center between 1970 and 2016. Results: Negative predictors of OS were age (OR = 1.07), male sex (OR = 1.63), and stage IIB, III, and IV (OR = 4.10, 5.42, and 7.54, respectively, vs. stage IA). Lack of initial PUVA response was strongly associated with negative OS (OR = 3.08). Kaplan-Meier analysis of age-, sex-, and stage-matched MF and FMF patients found similar OS between the 2 groups. The 5-year OS was 91% for FMF and 74% for MF. Meta-analysis of current data and 2 published studies where survival of FMF patients was compared to MF did not reveal statistically significant differences between these 2 diseases. Conclusions: When patients were matched for age, sex, and disease stage, folliculotropism did not affect OS in MF.

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“…[1][2][3][4][5][6][7][8][9][10] The mechanism by which the malignant cells home toward the follicle has not been clarified yet. [1][2][3][4][5][6][7][8][9][10] The mechanism by which the malignant cells home toward the follicle has not been clarified yet.…”

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confidence: 99%

Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression

et al. 2018

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Our data support the hypothesis of disruption of immune privilege based on the lower expression of HLA-G and higher expression of MHC-II in the follicular epithelium in mycosis fungoides compared to alopecia areata and normal scalp skin. The lack of difference between FMF and CMF groups did not support the role of these molecules as a driver of folliculotropism. The expression of MHC molecules seems to be different between neoplastic and inflammatory infiltrates. The definitive significance of expression of the MHC molecules remains unclear, and more studies are necessary to fully understand the role of these molecules in cutaneous lymphomas.

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New insights into folliculotropic mycosis fungoides (FMF): A single-center experience

Cited by 100 publications

References 28 publications

Dermoscopic characterization of folliculotropic mycosis fungoides selectively localized on trunk and limbs

Dermoscopic characterization of folliculotropic mycosis fungoides selectively localized on trunk and limbs

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression

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