New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway

Yang, Wenshan; Yin, Hong; Wang, Yichen; Wang, Yuanbo; Li, Xia; Wang, Chaochen; Liu, Ping; Hu, Yuan

doi:10.1016/j.chmed.2022.06.012

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…[3] The pathogenesis of depression is very complex, generally believed to be the interaction of biological, psychological, social and other factors, but there is no unified understanding at present. [4,5] At present, dozens of drugs including tricyclic and tetracyclic anti-depressants, selective 5-hydroxytryptamine (5-HT) reuptake inhibitors and monoamine oxidase inhibitors, have been applied for depression treatment. However, these drugs have been reported to be ineffective in 50 % of patients, and two-thirds of patients did not relieve symptoms after treatment.…”

Section: Introductionmentioning

confidence: 99%

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Qu,

Zheng,

et al. 2024

Chemistry & Biodiversity

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Bupleurum scorzonerifolium willd. (BS) and its vinegar‐baked product (VBS) has been frequently utilized for depression management in clinical Chinese medicine. This paper aims to elucidate the antidepressant mechanism of BS and VBS from the perspectives of metabonomics and gut microbiota. A rat model of depression was established by CUMS combined with feeding alone to evaluate the antidepressant effects of BS and VBS. UPLC‐Q‐TOF‐MS/MS‐based metabolomics and 16S rRNA sequencing of rat feces were applied and the correlation of differential metabolic markers and intestinal floras was analyzed. The result revealed that BS and VBS significantly improved depression‐like behaviors and the levels of monoamine neurotransmitters in CUMS rats. There were 27 differential endogenous metabolites between CUMS and normal rats, which were involved in 8 metabolic pathways. Whereas, BS and VBS could regulate 18 and 20 metabolites respectively, wherein fifteen of them were shared metabolites. On the genus level, BS and VBS could regulate twenty‐five kinds of intestinal floras in CUMS rats, that is, they increased the abundance of beneficial bacteria and decreased the abundance of harmful bacteria. In conclusion, both BS and VBS exert excellent antidepressant effects by regulating various metabolic pathways and ameliorating intestinal microflora dysfunction.

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Section: Introductionmentioning

confidence: 99%

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Qu,

Zheng,

et al. 2024

Chemistry & Biodiversity

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“…Recently, there has been a growing body of evidence supporting the widespread use of transcriptomics and proteomics in enhancing our understanding of pathophysiological mechanisms and facilitating the development of diagnostic tools for various diseases ( Li et al, 2020 ; Mu et al, 2020 ; Yang et al, 2021 ; Yang et al, 2023 ). Moreover, the utilization of weighted gene coexpression network analysis (WGCNA) offers the ability to illustrate the interconnections between diverse genes through the creation of a co-expression network, which not only enables the identification of modules that are associated with specific phenotypes but also proves to be more efficient in the investigation of crucial pathways and genes involved in numerous human disorders ( Langfelder and Horvath, 2008 ; Zhang et al, 2024 ).…”

Section: Introductionmentioning

confidence: 99%

Integrative transcriptome-proteome approach reveals key hypoxia-related features involved in the neuroprotective effects of Yang Xue oral liquid on Alzheimer’s and Parkinson’s disease

Chen,

Cheng,

Tang

et al. 2024

Front. Pharmacol.

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Introduction: This study investigates the role of hypoxia-related genes in the neuroprotective efficacy of Yang Xue oral liquid (YXKFY) in Alzheimer’s disease (AD) and Parkinson’s disease (PD).Methods and results: Using differential expression and weighted gene co-expression network analysis (WGCNA), we identified 106 and 9 hypoxia-associated genes in AD and PD, respectively, that are implicated in the transcriptomic and proteomic profiles. An artificial intelligence-driven hypoxia signature (AIDHS), comprising 17 and 3 genes for AD and PD, was developed and validated across nine independent cohorts (n = 1713), integrating 10 machine learning algorithms and 113 algorithmic combinations. Significant associations were observed between AIDHS markers and immune cells in AD and PD, including naive CD4+ T cells, macrophages, and neutrophils. Interactions with miRNAs (hsa-miR-1, hsa-miR-124) and transcription factors (USF1) were also identified. Single-cell RNA sequencing (scRNA-seq) data highlighted distinct expression patterns of AIDHS genes in various cell types, such as high expression of TGM2 in endothelial cells, PDGFRB in endothelial and mesenchymal cells, and SYK in microglia. YXKFY treatment was shown to repair cellular damage and decrease reactive oxygen species (ROS) levels. Notably, genes with previously dysfunctional expression, including FKBPL, TGM2, PPIL1, BLVRB, and PDGFRB, exhibited significant recovery after YXKFY treatment, associated with riboflavin and lysicamine.Conclusion: The above genes are suggested to be central to hypoxia and neuroinflammation responses in AD and PD, and are potential key mediators of YXKFY’s neuroprotective action.

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A step‐by‐step progressive strategy exploring whole metabolic profiles in vivo for Polygalae Radix with/without licorice

Zhao,

Xing

et al. 2024

Phytochemical Analysis

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IntroductionPolygalae Radix (PR) is known to relieve toxicity and increase efficiency in various diseases after processing. However, there were few studies for aromatic carboxylic acids (ACAs) due to the limited detection, especially for the metabolites within m/z 100–2000.ObjectivesThis study aims to elucidate the whole metabolism of PR with/without licorice (LP), focusing on metabolites within m/z 100–2000 and pharmacodynamics in vivo.Material and methodsThis study was established by the combination of multidimensional ultra‐high performance liquid chromatography coupled with a mass spectrometer (UPLC–MS) technology with protein sedimentation method to analyze metabolites in plasma, brain, colon, and stomach contents. Quantitative monitoring ACAs was enhanced with our novel stable isotope derivatization (SILD) technique. And then the pharmacokinetics (PK) study of relatively large metabolites was carried out. A targeted network pharmacology approach was established to avoid false positive results, mapping interactions relevant to Alzheimer's disease (AD), and other conditions.ResultsThe 85 polygala metabolites were qualitatively analyzed in plasma, brain, colon, and stomach contents. The 11 types of relatively large metabolites and 8 types of ACAs were quantitatively monitored. Among them, nine types of relatively large metabolites were assessed through PK studies. In targeted network pharmacology, it highlighted the significance of small molecular metabolites, including ACAs et al, which were frequently overlooked. LP may play a more key role mainly through neural active ligand‐receptor interaction, AD, and pertussis pathways. These findings have outlined a step‐by‐step strategy for in‐depth research in vivo, laying a foundation for further verification of biological function.

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New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway

Cited by 4 publications

References 65 publications

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Two Omics Methods Expose Anti‐Depression Mechanism of Raw and Vinegar‐Baked Bupleurum Scorzonerifolium Willd

Integrative transcriptome-proteome approach reveals key hypoxia-related features involved in the neuroprotective effects of Yang Xue oral liquid on Alzheimer’s and Parkinson’s disease

A step‐by‐step progressive strategy exploring whole metabolic profiles in vivo for Polygalae Radix with/without licorice

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