New Insights into Breast and Endometrial Cancers

Miki, Yasuhiro

doi:10.3390/cancers12092595

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…Wang et al demonstrated the superiority of the prognostic accuracy of multiRNA combined with clinical-stage over clinical stage alone, according to FIGO and over some genetic prognostic predictive models available in the literature [95]. Some recent reviews had already highlighted the role of ncRNAs in developing female cancers [8,98,99], but they mainly focused on their mechanism in tumorigenesis. The present review is the first to identify and select a pool of ncRNAs that have a prognostic role and can influence the therapeutic choice based on the epigenetic profile of EC patients.…”

Section: Discussionmentioning

confidence: 99%

Towards Personalized Medicine: Non-Coding RNAs and Endometrial Cancer

et al. 2021

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Endometrial cancer (EC) is the most frequent female cancer associated with excellent prognosis if diagnosed at an early stage. The risk factors on which clinical staging is based are constantly updated and genetic and epigenetic characteristics have recently been emerging as prognostic markers. The evidence shows that non-coding RNAs (ncRNAs) play a fundamental role in various biological processes associated with the pathogenesis of EC and many of them also have a prognosis prediction function, of remarkable importance in defining the therapeutic and surveillance path of EC patients. Personalized medicine focuses on the continuous updating of risk factors that are identifiable early during the EC staging to tailor treatments to patients. This review aims to show a summary of the current classification systems and to encourage the integration of various risk factors, introducing the prognostic role of non-coding RNAs, to avoid aggressive therapies where not necessary and to treat and strictly monitor subjects at greater risk of relapse.

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Section: Discussionmentioning

confidence: 99%

Towards Personalized Medicine: Non-Coding RNAs and Endometrial Cancer

et al. 2021

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“…Hormones, especially steroids, are closely involved in the physiological functions and proliferation of various target tissues and have long been known to play a key role in the tumorigenesis or carcinogenesis of these target tissues. It is well known that sex steroid hormones, such as estrogen and androgen, have a close influence on the development and malignant behavior of endometrial, ovarian, and breast cancers in women and prostate cancer in men [ 1 , 2 ]. These cancers are hormone-dependent, and some of the mechanisms of hormone action have been identified as therapeutic targets.…”

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confidence: 99%

“…Therefore, research on the crosstalk between the ER and receptors for physiologically active substances, including hormones, is required to further elucidate ER signaling in breast cancer cells. Cancer tissue is composed of parenchymal cancer cells and surrounding stromal cells; the intratumoral stroma includes fibroblasts, adipocytes, inflammatory cells, and capillaries [ 1 ]. Adipose stem cells (ASCs) from obese donors secrete abundant leptin and increase ERα and aromatase expression in breast cancer [ 11 ].…”

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confidence: 99%