New Insights into Associated Co-morbidities in Patients with Cutaneous T-cell Lymphoma (Mycosis Fungoides)

Abstract

Studies of associated cancer in patients with mycosis fungoides (MF) have focused primarily on secondary cancers in North American and European populations. This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were collected from a database of population- based cohort (683 patients; 1,700 controls) and an institution- based cohort (343 patients; 846 controls) and analysed by univariate and multivariate methods. MF was significantly associated with Hodgkin's lymphoma in both cohorts (multivariate odds ratio (OR) 7.83, univariate OR ∞, respectively); acute leukaemia (multivariate OR 10.1, first cohort) and lung cancer (multivariate OR 10.15, second cohort). MF was significantly associated with anxiety and depression (multivariate OR 1.59, OR 1.51, respectively in first cohort). The current study provides support to the associations between MF and other cancers: Hodgkin's lymphoma, acute leukaemia and lung cancer. The study also emphasizes the association between MF and anxiety and depression.

Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa

“…Nevertheless, the validity of Clalit's registry of diagnoses has previously been found to be high . In recent years, we have utilized the Clalit database to study disease associations in patients with psoriasis, pemphigus, lichen planus and mycosis fungoides …”

“…12 In recent years, we have utilized the Clalit database to study disease associations in patients with psoriasis, [13][14][15][16][17] pemphigus, 18 lichen planus 19 and mycosis fungoides. 20 The study was designed as a cross-sectional study using data mining techniques utilizing the Clalit database. Patients were defined as having HS when there was at least one documented diagnosis of HS in the medical records between 1997 and 2011, registered by a Clalit dermatologist (3207 patients).…”

Frequency of primary cutaneous lymphoma variants in Austria: retrospective data from a dermatology referral centre between 2006 and 2013

“…2 MF and particularly LyP are known to appear in concomitance with other haematological and lymphoproliferative disorders and accordingly this association was found in four MF and three LyP patients in our cohort. 9, 22,23,24,25 In addition, other malignancies were found to be increased in MF. Hahtola et al described an increased risk of lung cancer in CTCL patients.…”

Patient education and support group for patients with cutaneous lymphoma and their caregivers

“…On average, the diagnosis of the most common form of CTCL, mycosis fungoides (MF), is delayed by several years and requires multiple biopsies . While the prognosis is good for early‐stage disease, the disease is typically chronic, with relapses despite treatment, and patients can feel isolated . Patient advocacy groups, such as the Cutaneous Lymphoma Foundation, have made efforts to bring more attention to this disease and address the psychosocial needs of patients.…”

“…There has been little research evaluating the nonmedical needs of patients with CTCL and their caregivers. Being diagnosed with CTCL, regardless of prognosis or stage, has an impact on patients’ physical, emotional and financial well‐being. This is the first time a support group for patients with CTCL has been evaluated.…”