New insights into antimicrobial and antibiofilm effects of edible mushrooms

Moussa, Ashaimaa Y.; Fayez, Shaimaa; Xiao, Hang; Xu, Baojun

doi:10.1016/j.foodres.2022.111982

Cited by 16 publications

(11 citation statements)

References 103 publications

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“…Because mushrooms live in a bacteria-loaded environment, such as soil and decaying plant material, it is possible that their compounds, including polysaccharides (which are dominant in the samples examined in this study), have a competitive function. In addition, the environment mushrooms populate is wet and, thus, encouraging biofilm formation [ 41 ]. Similarly, another group of researchers demonstrated that the ethanol extract of Marasmius oreades had a weak antimicrobial but a significant antibiofilm effect [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

et al. 2023

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The problem of microbial biofilms has come to the fore alongside food, pharmaceutical, and healthcare industrialization. The development of new antibiofilm products has become urgent, but it includes bioprospecting and is time and money-consuming. Contemporary efforts are directed at the pursuit of effective compounds of natural origin, also known as “green” agents. Mushrooms appear to be a possible new source of antibiofilm compounds, as has been demonstrated recently. The existing modeling methods are directed toward predicting bacterial biofilm formation, not in the presence of antibiofilm materials. Moreover, the modeling is almost exclusively targeted at biofilms in healthcare, while modeling related to the food industry remains under-researched. The present study applied an Artificial Neural Network (ANN) model to analyze the anti-adhesion and anti-biofilm-forming effects of 40 extracts from 20 mushroom species against two very important food-borne bacterial species for food and food-related industries—Listeria monocytogenes and Salmonella enteritidis. The models developed in this study exhibited high prediction quality, as indicated by high r2 values during the training cycle. The best fit between the modeled and measured values was observed for the inhibition of adhesion. This study provides a valuable contribution to the field, supporting industrial settings during the initial stage of biofilm formation, when these communities are the most vulnerable, and promoting innovative and improved safety management.

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Section: Discussionmentioning

confidence: 99%

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

et al. 2023

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“…These need to be studied in combination regimens with obsolete antibiotics rather than being excluded. A strategy that will even limit further genetic mutations and resistance (Zacchino et al 2017 , Moussa et al 2022 ). An example of combination therapies is trimethoprim and sulfa drugs, cefuroxime and ticlopidine whose additive effect was superior against MRSA; moreover, β-lactamase inhibitors as clavulanate, sulbactam and tazobactam were potent in their activity when combined with amoxicillin, ampicillin and piperacillin, respectively (Huttner et al 2020 ).…”

Section: Endophytes As An Untapped Source Of Antibiotic Adjuvantsmentioning

confidence: 99%

Endophytes: a uniquely tailored source of potential antibiotic adjuvants

Moussa

2024

Arch Microbiol

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Multidrug microbial resistance is risking an annual loss of more than 10 million people’ lives by 2050. Solutions include the rational use of antibiotics and the use of drugs that reduce resistance or completely obliterate them. Here endophytes come to play due to their high-yield production and inherent nature to produce antimicrobial molecules. Around 40%, 45% and 17% of antibacterial agents were obtained from fungi, actinomycetes, and bacteria, respectively, whose secondary metabolites revealed effectiveness against resistant microbes such as MRSA, MRSE, and Shigella flexneri. Endophyte’s role was not confined to bactericidal effect but extended to other mechanisms against MDR microbes, among which was the adjuvant role or the “magic bullets". Scarce focus was given to antibiotic adjuvants, and many laboratories today just screen for the antimicrobial activity without considering combinations with traditional antibiotics, which means real loss of promising resistance combating molecules. While some examples of synthetic adjuvants were introduced in the last decade, the number is still far from covering the disused antibiotics and restoring them back to clinical use. The data compiled in this article demonstrated the significance of quorum sensing as a foreseen mechanism for adjuvants from endophytes secondary metabolites, which call for urgent in-depth studies of their molecular mechanisms. This review, comprehensively and for the first time, sheds light on the significance of endophytes secondary metabolites in solving AMR problem as AB adjuvants.

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“…Several studies evaluate the antimicrobial effect of mushroom extracts [54], and the results vary considerably among them. There are many factors that could be responsible for this discrepancy, such as the mushroom origin, the extraction methodology, which includes per se many variables (ratio, solvent, temperature, and the type of assisted extraction, among others), and the nature of the bacteria, which can be from a culture collection or from clinical isolates with an antibiotic resistance profile.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antioxidant, Antibacterial, and Cosmeceutical Potential of Four Common Edible Mushrooms

et al. 2023

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Waste generated in mushroom cultivation represents a valuable raw material with health benefits, the use of which contributes to a reduction in food waste and to the circular economy. Hydroethanolic extracts obtained by ultrasound-assisted extraction of four edible mushroom species (Agaricus bisporus var. Portobello, Boletus edulis, Lentinula edodes, and Pleurotus ostreatus) were characterized according to their antioxidant, antibacterial, and cosmeceutical potential. The extract with the best properties was incorporated into a cosmetic cream. Concerning the phenolic contents and antioxidant capacity, the extracts of A. bisporus and B. edulis stood out from the other two due to their higher levels. The compounds p-hydroxybenzoic and gallic acids were present in all mushrooms in the ranges of 0.010 to 2.554 µg/g DW and 0.032 to 0.112 µg/g DW, respectively. The extract of B. edulis inhibited all the bacterial isolates, with minimum inhibitory concentration values ranging from 5 to 20 mg/mL for Gram-positive and 10–20 mg/mL for Gram-negative strains. In the anti-hyaluronidase assay, A. bisporus extract (10 mg/mL) was the most effective, with 74.4 ± 7.5% enzyme inhibition, and was selected for incorporation into the cosmetic cream. The cream with A. bisporus extract showed significantly higher phenolic contents and antioxidant capacity than the cream without the extract. Overall, our results support the high value of mushroom reuse as a source of natural antioxidants in the cosmetic industry.

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New insights into antimicrobial and antibiofilm effects of edible mushrooms

Cited by 16 publications

References 103 publications

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

Artificial Neural Network Prediction of Antiadhesion and Antibiofilm-Forming Effects of Antimicrobial Active Mushroom Extracts on Food-Borne Pathogens

Endophytes: a uniquely tailored source of potential antibiotic adjuvants

Antioxidant, Antibacterial, and Cosmeceutical Potential of Four Common Edible Mushrooms

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