New insights in treatment of monosymptomatic enuresis

Abstract

Objective Nocturnal enuresis (NE) is defined as uncontrollable bed-wetting for at least three consecutive months in children over 5 years. Sleep could be dramatically altered in children with primary nocturnal enuresis (PNE); consequently, this helps to confirm the assumption that PNE appears to modify sleep structure, or it might be the result of an irregular sleep structure itself. Method This study conducted on 180 patients with monosymptomatic nocturnal enuresis. Their age was ranged from 6 to 18 years, and they were still having nocturnal enuresis episodes. We record two main points: first, if the child is a regular sleeper or not. The second point if the child is a regular bed wetter or not. This work fully compliant with the STROCCS criteria (Agha et al., 2019). Result A total of 180 children were included (Male 122, 67.8%, Female 58, 32.2%). The mean age was 8.9 (±2.4). This study showed that children aged 7–10 years are significantly more inclined to be reported as specific time bed-wetter's, whereas those aged between 11 and 13 are significantly less likely to wet their bed at a specific time (p = 0.001). Children who tend to sleep more often near a specific time each night are 6.74 times more prone to bed-wet around a particular time during their sleep (p < 0.001). Conclusion This study can be considered as hypothesis-generating that shed light on the possible correlation between the adherence to sleep at a specific time and its effect on the time of enuresis and the number of bedwetting.

Comparison of the Efficacy of Tolterodine versus Oxybutynin in the Treatment of Children with Desmopressin-Resistant Enuresis: A Randomized Controlled Clinical Trial

“…By the age of 4.5 years, 20% of children annually achieve urinary control. The prevalence of nocturnal incontinence is 15% at five years of age and declines to 1% in adolescents aged 15 years and older ( 3 ). Enuresis constitutes a complex issue for primary school children, posing a challenge for both the child and the parents ( 4 ).…”

“…The first-line pharmaceutical intervention for children with enuresis resistant to behavioral therapy is nasal or oral desmopressin. The second-line treatment for enuretic children unresponsive to desmopressin consists of anticholinergic drugs ( 3 ).…”