New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2

Bouraoui, Aicha; Louzada, Ruy Andrade; Aimeur, Sana; Waeytens, Jehan; Wien, Frank; Dang, Pham My-Chan; Bizouarn, Tania; Dupuy, Corinne; Baciou, Laura

doi:10.1016/j.freeradbiomed.2023.02.019

Cited by 2 publications

(1 citation statement)

References 89 publications

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“…Recently, the regulatory protein Poldip2 was found to act as an isoform-specific tunable switch for the activities of different NADPH oxidases. This selective regulatory role of Poldip2, positive for Nox4 or negative for Nox2, could regulate the type and level of ROS generated by p22 phox -containing Nox isoforms in cells and tissues [ 67 ].…”

Section: Cross-talk Of Nadph Oxidases Inflammation Hypercholesterolem...mentioning

confidence: 99%

Cross-Talk of NADPH Oxidases and Inflammation in Obesity

Morawietz¹,

Brendel²,

Diaba-Nuhoho

et al. 2023

Antioxidants

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Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity. NADPH oxidases are major sources of reactive oxygen species in the cardiovascular system and in metabolically active cells and organs. An impaired balance due to the increased formation of reactive oxygen species and a reduced antioxidative capacity contributes to the pathophysiology of cardiovascular and metabolic diseases and is linked to inflammation as a major pathomechanism in cardiometabolic diseases. Non-alcoholic fatty liver disease is particularly characterized by increased oxidative stress and inflammation. In recent years, COVID-19 infections have also increased oxidative stress and inflammation in infected cells and tissues. Increasing evidence supports the idea of an increased risk for severe clinical complications of cardiometabolic diseases after COVID-19. In this review, we discuss the role of oxidative stress and inflammation in experimental models and clinical studies of obesity, cardiovascular diseases, COVID-19 infections and potential therapeutic strategies.

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Section: Cross-talk Of Nadph Oxidases Inflammation Hypercholesterolem...mentioning

confidence: 99%