New Insights in the Clinical Understanding of Behçet's Disease

Abstract

Behçet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms (arthritis, gastrointestinal ulcers, epididymitis, vascular lesions, and central nervous system symptoms). Although the etiology of Behçet's disease is still unknown, there have been recent advances in immunopathogenic studies, genome-wide association studies, animal models, diagnostic markers, and new biological agents. These advances have improved the clinical understanding of Behçet's disease and have enabled us to develop new treatment strategies for this intractable disease, which remains one of the leading causes of blindness.

Bilateral Hemophthalmus — the First Symptom of Behcet’s Disease (Clinical Case)

“…В мае-июне 2014 г. пациенту проведено биохимиче-ское исследование крови: Альбумин -61,5% (норма-55,8-66,1%), альфа1-глобулин -4,6% (2,9-4,9), альфа2-глобулин -11,1% (7,(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)8), бета1-глобулин -5,7% (4,7-7,2), бета2-глобулин -5,6% (3,2-6,5), гамма-глобулин -11,5% (11,(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)8). ОАК: WBC 7,9-109%, LYM 38,7%, MON 7,3%, GRA 54 %, RBC 5,3-1012%, HGB 149g/l, HCT 406, MCV 78, PLT 376-109%.…”

“…The patient was counseled at the Institute of Rheumatology, where were determined the diagnosis of Behcet's disease.This paper shows the clinical data and the results of additional tests (OCT, fluorescein angiography, ultrasonography), the results of blood biochemical examination and immune status. Болезнь Бехчета (болезнь Адамантиада -Бехчета, болезнь «шелкового пути») -системное хроническое идиопатическое воспалительное заболевание неизвест-ной этиологии с рецидивирующим течением [1][2][3][4][5][6][7][8][9][10][11].…”

“…Известно, что в Японии и Корее данной патологией чаще страдают женщины, в то время как в странах Среднего Востока среди больных преобладают мужчины. Болезнью Бехчета страдают преимуществен-но молодые люди в возрасте 20-40 лет [2,3,6,9,10,12].…”

Oxidative stress markers in patients with Behcet’s disease

“…He also suggested the possible viral etiology. 1 Nowadays, Behcet's disease (BD) has been identified as an inflammatory disorder characterized by recurrent oral aphthous ulcers and at least two of the following features: recurrent genital ulcers, eye involvement, skin lesions, and a positive pathergy test. 2 Although the etiology of BD is obscure, it is believed to be triggered by environmental factors such as microbial agents in individuals with a particular genetic background and their interactions.…”

Clinical Characteristics of Patients with Behçet’s Disease Followed at Outpatient Clinic of Chronic Dermatological Diseases

“…Behçet hastalığı (BH); tekrarlayan oral aftlar, genital ülserler ve oküler tutulum ile karakterize, kronik seyirli bir hastalıktır (1). İlk kez 1937 yılında bir Türk Dermatolog olan Hulusi Behçet tarafından tekrarlayıcı oral ve genital ülserler ile birlikte oküler bulgular (hipopiyonlu iridosiklit) şeklinde tanımlanmıştır (2).…”