New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke

Wei, Ziqing; Xie, Yi; Wei, Mingze; Zhao, Haitao; Ren, Kai-Di; Feng, Qi; Xu, Yuming

doi:10.3389/fphar.2022.1020918

Cited by 12 publications

(7 citation statements)

References 300 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have gradually uncovered the pathological process of ferroptosis in the neurovascular unit of acute stroke. Altered homeostasis of iron [ 54 ], the most abundant metal in the brain necessary for cerebral metabolism [ 46 ], produces abnormal overload in specific regions of the brain, promoting disease progression [ 37 ]. This process accompanies pathological aggravation and is considered to be an important pathophysiological factor involved in secondary damage after ischemic stroke [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

Ferroptosis and Senescence: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

IJMS

View full text Add to dashboard Cite

Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decay in cellular functions and proliferation, resulting in increased cellular damage and death. This condition plays an essential role in the aging process and significantly contributes to the development of age-related complications. On the other hand, ferroptosis is a systemic cell death pathway characterized by excessive iron accumulation followed by the generation of reactive oxygen species (ROS). Oxidative stress is a common trigger of this condition and may be induced by various factors such as toxins, drugs, and inflammation. Ferroptosis is linked to numerous disorders, including cardiovascular disease, neurodegeneration, and cancer. Senescence is believed to contribute to the decay in tissue and organ functions occurring with aging. It has also been linked to the development of age-related pathologies, such as cardiovascular diseases, diabetes, and cancer. In particular, senescent cells have been shown to produce inflammatory cytokines and other pro-inflammatory molecules that can contribute to these conditions. In turn, ferroptosis has been linked to the development of various health disorders, including neurodegeneration, cardiovascular disease, and cancer. Ferroptosis is known to play a role in the development of these pathologies by promoting the death of damaged or diseased cells and contributing to the inflammation often associated. Both senescence and ferroptosis are complex pathways that are still not fully understood. Further research is needed to thoroughly investigate the role of these processes in aging and disease, and to identify potential interventions to target such processes in order to prevent or treat age-related conditions. This systematic review aims to assess the potential mechanisms underlying the link connecting senescence, ferroptosis, aging, and disease, and whether they can be exploited to block or limit the decay of the physiological functions in elderly people for a healthy longevity.

show abstract

Section: Resultsmentioning

confidence: 99%

Ferroptosis and Senescence: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…With deepening research on ferroptosis in various diseases, increasingly regulatory mechanisms of ferroptosis have been discovered 14 , 15 , 50 . More importantly, several classical regulators of DKD have been identified to effectively modulate ferroptosis 83 , 88 .…”

Section: The Crosstalk Between Ferroptosis and Other Cellular Process...mentioning

confidence: 99%

“…Biochemically, the deposition of intracellular iron, abundance of reactive oxygen species (ROS) and aggregation of lipid peroxides are manifested during the occurrence of ferroptosis [12]. With more advanced research, ferroptosis was discovered to be pivotal in a range of diseases, including cancer, aging, neurological diseases, cardiovascular diseases and kidney diseases [13][14][15]. In kidney diseases, most scientists have paid more attention to the correlation of ferroptosis and acute kidney injury (AKI), renal cell carcinoma and polycystic kidney [15][16][17], and relatively little concrete evidence to support ferroptotic contribution to the development of DKD.…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of Ferroptosis in Diabetic Kidney Disease: Molecular Mechanisms and Therapeutic Opportunities

Wang¹,

Li²,

Zheng³

et al. 2023

Int. J. Biol. Sci.

Self Cite

View full text Add to dashboard Cite

Diabetic kidney disease (DKD) is one of the most common and severe microvascular complications of diabetes mellitus (DM), and has become the leading cause of end-stage renal disease (ESRD) worldwide. Although the exact pathogenic mechanism of DKD is still unclear, programmed cell death has been demonstrated to participate in the occurrence and development of diabetic kidney injury, including ferroptosis. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has been identified to play a vital role in the development and therapeutic responses of a variety of kidney diseases, such as acute kidney injury (AKI), renal cell carcinoma and DKD. In the past two years, ferroptosis has been well investigated in DKD patients and animal models, but the specific mechanisms and therapeutic effects have not been fully revealed. Herein, we reviewed the regulatory mechanisms of ferroptosis, summarized the recent findings associated with the involvement of ferroptosis in DKD, and discussed the potential of ferroptosis as a promising target for DKD treatment, thereby providing a valuable reference for basic study and clinical therapy of DKD.

show abstract

“…Recent studies have gradually uncovered the pathological process of ferroptosis in the neurovascular unit of acute stroke. Altered homeostasis of iron [38], the most abundant metal in the brain necessary for cerebral metabolism [39], produces abnormal overload in specific regions of the brain, promoting disease progression [37]. This process accompanies pathological aggravation and is considered to be an important pathophysiological factor involved in secondary damage after ischemic stroke [40].…”

Section: Brain Damagementioning

confidence: 99%

Ferroptosis and Senescence: A Systematic Review

Coradduzza¹,

Congiargiu²,

Chen³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Senescence is a cellular ageing process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. This condition plays an essential role in the ageing process and significantly contributes to the development of age-related complications. On the other hand, ferroptosis is a systemic cell death characterized by excessive iron accumulation followed by the generation of reactive oxygen species (ROS). Oxidative stress is a common trigger of this condition and may be induced by various factors such as toxins, drugs, and inflammation. Ferroptosis is linked to numerous illnesses, including cardiovascular disease, neurodegeneration, and cancer. Relevance of these conditions to ageing and disease: Senescence is believed to contribute to the decline in tissue and organ function that occurs with ageing. It has also been linked to the development of age-related pathologies, such as cardiovascular diseases, diabetes, and cancer. In particular, senescent cells have been shown to produce inflammatory cytokines and other pro-inflammatory molecules that can contribute to these conditions. On the other hand, ferroptosis has been linked to the development of various health disorders, including neurodegeneration, cardiovascular disease, and cancer [1]. It is known to play a role in developing these diseases by promoting the death of damaged or diseased cells and contributing to the inflammation often associated with them. Both senescence and ferroptosis are complex processes that are still not fully understood. Further research is needed to thoroughly understand the role of these processes in ageing and disease, and to identify potential interventions to target these processes to prevent or treat age-related conditions. Objectives: This systematic review aims to assess the potential mechanisms underlying the link connecting senescence, ferroptosis, ageing, and disease.

show abstract

New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke

Cited by 12 publications

References 300 publications

Ferroptosis and Senescence: A Systematic Review

Ferroptosis and Senescence: A Systematic Review

Emerging Role of Ferroptosis in Diabetic Kidney Disease: Molecular Mechanisms and Therapeutic Opportunities

Ferroptosis and Senescence: A Systematic Review

Contact Info

Product

Resources

About