New insight into the role of the complement in the most common types of retinopathy-current literature review

Chrzanowska, Martyna; Modrzejewska, Anna; Modrzejewska, Monika

doi:10.18240/ijo.2018.11.19

Cited by 9 publications

(5 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The RPE cells are monolayered pigmented cells located just outside the neurosensory retina that nourish retinal visual cells; RPE is firmly attached to the underlying choroid and overlying retinal visual cells [ 25 ]. Therefore, dysfunction of the RPE is associated with various retinopathies including age-related macular degeneration and diabetic retinopathy [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells

et al. 2021

View full text Add to dashboard Cite

Primary cilia mediate the interactions between cells and external stresses. Thus, dysregulation of primary cilia is implicated in various ciliopathies, e.g., degeneration of the retina caused by dysregulation of the photoreceptor primary cilium. Particulate matter (PM) can cause epithelium injury and endothelial dysfunction by increasing oxidative stress and inflammatory responses. Previously, we showed that PM disrupts the formation of primary cilia in retinal pigment epithelium (RPE) cells. In the present study, we identified 2-isopropylmalic acid (2-IPMA) as a novel inducer of primary ciliogenesis from a metabolite library screening. Both ciliated cells and primary cilium length were increased in 2-IPMA-treated RPE cells. Notably, 2-IPMA strongly promoted primary ciliogenesis and restored PM2.5-induced dysgenesis of primary cilia in RPE cells. Both excessive reactive oxygen species (ROS) generation and activation of a stress kinase, JNK, by PM2.5 were reduced by 2-IPMA. Moreover, 2-IPMA inhibited proinflammatory cytokine production, i.e., IL-6 and TNF-α, induced by PM2.5 in RPE cells. Taken together, our data suggest that 2-IPMA ameliorates PM2.5-induced inflammation by promoting primary ciliogenesis in RPE cells.

show abstract

Section: Resultsmentioning

confidence: 99%

2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, C5a binds to receptors on retinal cells, triggering the production of in ammatory and angiogenic factors. Additionally, the interaction between C5aR and C5a in Müller cells results in the release of IL-6 and VEGF, which contribute to the pathology of DR 19,20 . Several studies have demonstrated that C5 levels are increased in human plasma and vitreous samples in cases of DR and AMD, respectively [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

Identification of key biomarkers in Diabetic retinopathy and age-related macular degeneration by integrated bioinformatics analysis

Feng,

Gao

2024

Preprint

View full text Add to dashboard Cite

Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the main causes of visual impairment in individuals aged 50 and above globally. Interestingly, there is a complex relationship between DR and AMD, although the specific mechanisms connecting them are not yet fully understood. This study aims to identify common gene signatures and uncover potential molecular mechanisms involved in the development of both DR and AMD. The gene expression profiles of GSE160306 and GSE29801 were obtained from the Gene Expression Omnibus (GEO) database to analyze the differences in gene expression between AMD, DR, and healthy samples. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the clusterProfiler package in R. The protein-protein interaction (PPI) network was constructed using the STRING database and Cytoscape software. Additionally, meaningful hub genes were identified through machine-learning algorithms. Receiver operating characteristic (ROC) analyses were conducted to assess the diagnostic value of the differentially expressed genes (DEGs) for DR and AMD. Overall, a total of 5 DEGs (C5, KRAS, FSTL1, KCNV2, and PILRB) were identified, and further analysis revealed key pathways, gene modules, and co-expression networks associated with DR and AMD.

show abstract

“…The complement system helps regulate the immune response and inflammation, and its dysfunction is linked to autoimmune disease [ 24 ]. DM affects the production of complement proteins, and elevated levels of CFB have been detected in the vitreous of patients with PDR, despite also being implicated in the early stages of DR [ 25 ]. Evidence from previous studies suggests the complement system is involved in the development of DR.…”

Section: Discussionmentioning

confidence: 99%

Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy

Pearce

Sivaprasad

Broadgate

et al. 2023

Vision

View full text Add to dashboard Cite

Diabetic Retinopathy (DR) is a leading cause of preventable visual impairment in the working age population. Despite the increasing prevalence of DR, there remain gaps in our understanding of its pathophysiology. This is a prospective case-control study comparing the genetic profiles of patients with no DR vs. non-proliferative DR (NPDR) focusing on intraretinal microvascular abnormalities (IRMA) and venous beading (VB) in Caucasians. A total of 596 participants were recruited to the study; 199 with moderate/severe NPDR and 397 with diabetes for at least 5 years without DR. Sixty-four patients were excluded due to technical issues. In total, 532 were analysed; 181 and 351 were in the NPDR group and no DR group, respectively. Those with severe IRMA and VB had distinctly different genetic profiles from each other and from the no DR group, which further supports the theory that these two features of DR might have different etiologies. This also suggests that IRMA and VB are independent risk factors for the development of PDR and may have different pathophysiologies. If these findings are confirmed in larger studies, this could pave the way for personalised treatment options for those more at risk of developing different features of NPDR.

show abstract

New insight into the role of the complement in the most common types of retinopathy-current literature review

Cited by 9 publications

References 87 publications

2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells

2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells

Identification of key biomarkers in Diabetic retinopathy and age-related macular degeneration by integrated bioinformatics analysis

Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy

Contact Info

Product

Resources

About