New insight into the mechanism of granulocyte colony-stimulating factor (G-CSF) that induces the mobilization of neutrophils

Theyab, Abdulrahman; Algahtani, Mohammad; Alsharif, Khalaf F.; Hawsawi, Yousef M.; Alghamdi, Abdulaziz; Alghamdi, Adel; Akinwale, Jude

doi:10.1080/16078454.2021.1965725

Cited by 35 publications

(29 citation statements)

References 77 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neutrophil-attracting chemokines, such as CXCL1, CXCL2, or CXCL8, are induced in hypoxic tumor tissue, through the activation of hypoxia-inducible factor 1 (HIF-1α or β) [46,57,71], and support neutrophil migration to the tumor site via CXCR1 and CXCR2 receptors [72]. Moreover, inflammatory cytokines stimulate G-CSF production in TME and further induce the generation of new neutrophils in bone marrow (cancer-related granulopoiesis) [73,74]. Neutrophils, in turn, contribute to cancer-related inflammation, thus promoting angiogenesis and tumor progression (Figure 1).…”

Section: Neutrophils In Cancermentioning

confidence: 99%

The Good, the Bad, and the Ugly: Neutrophils, Angiogenesis, and Cancer

Ozel

Duerig

Domnich

et al. 2022

Cancers

View full text Add to dashboard Cite

Angiogenesis, the formation of new blood vessels from already existing vasculature, is tightly regulated by pro- and anti-angiogenic stimuli and occurs under both physiological and pathological conditions. Tumor angiogenesis is central for tumor development, and an “angiogenic switch” could be initiated by multiple immune cells, such as neutrophils. Tumor-associated neutrophils promote tumor angiogenesis by the release of both conventional and non-conventional pro-angiogenic factors. Therefore, neutrophil-mediated tumor angiogenesis should be taken into consideration in the design of novel anti-cancer therapy. This review recapitulates the complex role of neutrophils in tumor angiogenesis and summarizes neutrophil-derived pro-angiogenic factors and mechanisms regulating angiogenic activity of tumor-associated neutrophils. Moreover, it provides up-to-date information about neutrophil-targeting therapy, complementary to anti-angiogenic treatment.

show abstract

Section: Neutrophils In Cancermentioning

confidence: 99%

The Good, the Bad, and the Ugly: Neutrophils, Angiogenesis, and Cancer

Ozel

Duerig

Domnich

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Although we included the patients treated with G-CSF to identify neutropenia, the role of G-CSF in neutropenic sepsis is controversial. G-CSF can increase peripheral blood leukocyte and lymphocyte cell counts [ 39 ]. The current guidelines recommend prophylactic use of G-CSF for patients treated with chemotherapy with the risk of developing febrile neutropenia [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study

Kim

2022

Cancers

View full text Add to dashboard Cite

(1) Background: Neutropenia’s prognostic impact on mortality in cancer patients with septic shock remains controversial despite recent advances in cancer and sepsis management. This population-based, case–control study aimed to determine whether neutropenia could be related to an increase in short-term and long-term mortality. (2) Methods: This population-based, case–control study used data from the National Health Insurance Service of Korea. Adult cancer patients who presented to the emergency department with septic shock from 2009 to 2017 were included. The 30-day and 1-year mortality rates were evaluated as short-term and long-term outcomes. Cox proportional hazard regression was performed after adjusting for age, sex, Charlson comorbidity index, and neutropenia. (3) Results: In 43,466 adult cancer patients with septic shock, the 30-day and 1-year mortality rates were 52.1% and 81.3%, respectively. In total, 6391 patients had neutropenic septic shock, and the prevalent cancer type was lung cancer, followed by leukemia, non-Hodgkin’s lymphoma, stomach cancer, and colon cancer. Furthermore, 30-day and 1-year mortality was lower in patients with neutropenia than in those without neutropenia. After adjustment for confounders, neutropenia was independently associated with decreased 30-day and 1-year mortality rates. (4) Conclusions: In cancer patients presenting to the emergency department with septic shock, the presence of neutropenia did not increase mortality. This suggests that neutropenia may not be used as a single triage criterion for withholding intensive care in cancer patients presenting to the emergency department with septic shock.

show abstract

“…But neutrophilic deficiency leads to poor efficacy of conventional periodontal treatment ( 45 ). Studies have shown that patients with neutropenia have a positive response to human granulocyte colony-stimulating factor (G-CSF) ( 5 , 11 , 44 , 46 , 47 ). The literature has also suggested that HPS-2 patients need hematologic follow-up to identify when G-CSF therapy is needed ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Hermansky-Pudlak syndrome type 2: A rare cause of severe periodontitis in adolescents—A case study

et al. 2022

View full text Add to dashboard Cite

Background and aimsHermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism (OCA) and platelet storage pool deficiency. The HPS-2 subtype is distinguished by neutropenia, and little is known about its periodontal phenotype in adolescents. AP3B1 is the causative gene for HPS-2. A 13-year-old Chinese girl presented to our department suffering from gingival bleeding and tooth mobility. Her dental history was otherwise unremarkable. Suspecting some systemic diseases as the underlying cause, the patient was referred for medical consultation, a series of blood tests, and genetic tests. In this case study, periodontal status and mutation screening of one HPS-2 case are presented.MethodsBlood analysis including a complete blood count (CBC) and glycated hemoglobin levels were measured. Platelet transmission electron microscopy (PTEM) was performed to observe the dense granules in platelets. Whole-exome sequencing (WES) and Sanger sequencing were performed to confirm the pathogenic variants.ResultsA medical diagnosis of HPS-2 was assigned to the patient. Following the medical diagnosis, a periodontal diagnosis of “periodontitis as a manifestation of systemic disease” was assigned to the patient. We identified novel compound heterozygous variants in AP3B1 (NM_003664.4: exon7: c.763C>T: p.Q255*) and (NM_003664.4: exon1: c.53_56dup: p.E19Dfs*21) in this Chinese pedigree with HPS-2.ConclusionThis case study indicates the importance of periodontitis as a possible indicator of underlying systemic disease. Systemic disease screening is needed when a young patient presents with unusual, severe periodontitis, as the oral condition may be the first of a systemic abnormality. Our work also expands the spectrum of AP3B1 mutations and further provides additional genetic testing information for other HPS-2 patients.

show abstract

New insight into the mechanism of granulocyte colony-stimulating factor (G-CSF) that induces the mobilization of neutrophils

Cited by 35 publications

References 77 publications

The Good, the Bad, and the Ugly: Neutrophils, Angiogenesis, and Cancer

The Good, the Bad, and the Ugly: Neutrophils, Angiogenesis, and Cancer

Prognostic Impact of Neutropenia in Cancer Patients with Septic Shock: A 2009–2017 Nationwide Cohort Study

Hermansky-Pudlak syndrome type 2: A rare cause of severe periodontitis in adolescents—A case study

Contact Info

Product

Resources

About