New Insight into Intermediate Precursors of Brust–Schiffrin Gold Nanoparticles Synthesis

Zhu, Lili; Zhang, Chen; Guo, Chengchen; Wang, Xiaoliang; Sun, Pingchuan; Zhou, Dongshan; Chen, Wei; Xue, Gi

doi:10.1021/jp402116x

Cited by 39 publications

(43 citation statements)

References 35 publications

(58 reference statements)

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“…47,48 In an aqua regia-cleaned 500 mL round bottom flask, 400 mL of ultrapure water, 1.5 mL of The solution rapidly turns brown, then red-orange. 47,48 In an aqua regia-cleaned 500 mL round bottom flask, 400 mL of ultrapure water, 1.5 mL of The solution rapidly turns brown, then red-orange.…”

Section: Gold Nanoparticle Synthesis and Characterizationmentioning

confidence: 99%

Formation of supported lipid bilayers containing phase-segregated domains and their interaction with gold nanoparticles

Melby

Mensch

Lohse

et al. 2016

Environ. Sci.: Nano

104

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For nanoparticles that have been released into the environment, the cell membrane represents an initial site of interaction with eukaryotic cells. The encounter of nanoparticles with cellular membranes may alter membrane structure and function, lead to uptake into cells, or elicit adverse biological responses.Supported lipid bilayers have proven to be valuable ex vivo models for biological membranes, allowing investigation of their mechanisms of interaction with nanoparticles with a degree of control impossible in living cells. To date, the majority of research on nanoparticle interaction with supported lipid bilayers has employed membranes composed of single or binary mixtures of phospholipids. Cellular membranes contain a wide variety of lipids and exhibit lateral organization. Ordered membrane domains enriched in specific membrane components, also referred to as lipid rafts, have not been explored with respect to their interaction with nanoparticles. Here we develop model membranes containing segregated domains differing in fluidity that are amenable to investigation by a variety of surface-sensitive analytical techniques and demonstrate that these domains influence the extent of nanoparticle attachment to model membranes. We determined conditions that allow reliable formation of bilayers containing liquid-ordered domains enriched in sphingomyelin and cholesterol and confirmed their morphology by structured illumination and atomic force microscopies. We demonstrate that the presence of liquid-ordered domains increases attachment of cationic gold nanoparticles to model membranes relative to those lacking such domains under near physiological ionic strength conditions (0.1 M NaCl) at pH 7.4. We anticipate that these results will serve as the foundation for and motivate further study of nanoparticle interaction with phasesegregated domains.Environ. Sci.: Nano This journal isThe interaction of nanoparticles with cellular membranes can be a critical determinant in eliciting adverse outcomes in organisms. Model membranes composed of single or binary phospholipid mixtures have provided insight into the interaction with nanomaterials. Cytoplasmic membranes of living organisms, however, are made up of hundreds of components laterally organized into dynamic functional domains. We have established a platform to investigate the interaction of nanoparticles with model membranes containing ordered lipid domains with a variety of surface-sensitive analytical techniques. We demonstrate that the presence of these domains influences the interaction of cationic gold nanoparticles with model membranes under high ionic strength conditions. This study highlights the need to systematically investigate the interaction of nanoparticles with important membrane components and structures.

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Section: Gold Nanoparticle Synthesis and Characterizationmentioning

confidence: 99%

Formation of supported lipid bilayers containing phase-segregated domains and their interaction with gold nanoparticles

Melby

Mensch

Lohse

et al. 2016

Environ. Sci.: Nano

104

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“…[400][401][402] Of concern is how these results can be consistent with the details of the one-phase BrustSchiffrin synthesis [403] in a 5 : 1 methanol/water solvent containing a large excess of the strong reducing agent NaBH 4 . Au I -thiolate molecular compounds can be isolated as intermediates that must be subsequently reduced by borohydride to form nanoparticles.…”

mentioning

confidence: 80%

Putting David Craig’s Legacy to Work in Nanotechnology and Biotechnology

Reimers¹

2016

Aust. J. Chem.

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left us with a lasting legacy concerning basic understanding of chemical spectroscopy and bonding. This is expressed in terms of some of the recent achievements of my own research career, with a focus on integration of Craig's theories with those of Noel Hush to solve fundamental problems in photosynthesis, molecular electronics (particularly in regard to the molecules synthesized by Maxwell Crossley), and self-assembled monolayer structure and function. Reviewed in particular is the relation of Craig's legacy to: the 50-year struggle to assign the visible absorption spectrum of arguably the world's most significant chromophore, chlorophyll; general theories for chemical bonding and structure extending Hush's adiabatic theory of electron-transfer processes; inelastic electron-tunnelling spectroscopy (IETS); chemical quantum entanglement and the Penrose-Hameroff model for quantum consciousness; synthetic design strategies for NMR quantum computing; Gibbs free-energy measurements and calculations for formation and polymorphism of organic self-assembled monolayers on graphite surfaces from organic solution; and understanding the basic chemical processes involved in the formation of gold surfaces and nanoparticles protected by sulfur-bound ligands, ligands whose form is that of Au 0 -thiyl rather than its commonly believed Au I -thiolate tautomer.

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“…The mechanistic details of this two-phase method depend strongly on the type of employed ligand [64,[111][112][113] and are still in the process of being completely understood. [114][115][116] The reaction is accompanied by the concomitant formation of the corresponding disulfide.…”

Section: The Two-phase Brust-schiffrin Methodsmentioning

confidence: 99%

Building-block design

Ebeling

2015

Springer Theses

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In order to study AuNPs, they first have to be synthesized. As already described in Section 1.2.3.2, "gold nanoparticles" is just the umbrella term for particles with fundamentally different properties, which in particular depend on their size and the kind of stabilization and thus directly on the synthesis method. Several liquid-chemical synthesis methods were performed and surveyed regarding the suitability of the products for the envisaged functionalization experiments and the experimental ease of implementation with the accessible equipment. In this section, the results from these experiments, the characteristic properties of the produced nanoparticles and feasible analysis methods for them are discussed. In Chapter 8 "Nanohybrids of gold particles", the functionalization reactions of the synthesized AuNPs using coupling reactions on their surface, the study of their interactions with trithiocarbonate groups, and the employment in grafting-to reactions with different classes of polymers will be presented. General remarks on AuNP synthesis strategiesBecause of the high curvature, the gold atoms on the surface of AuNPs are unsaturated and especially reactive. In order to obtain a stable colloid in a AuNP synthesis, particle aggregation must be prevented. This can be achieved in three fundamentally different ways:Electrostatic stabilization: The nanoparticles carry a (remaining) charge, so that they (or the oppositely charged ligand layers) repel each other. Gold colloids stabilized in this manner are very sensitive to salts. * The list only refers to the stability of AuNPs. In order to form a colloidal solution, also a good solubility is required, which is a different matter concerning the interactions with the solvent.

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New Insight into Intermediate Precursors of Brust–Schiffrin Gold Nanoparticles Synthesis

Cited by 39 publications

References 35 publications

Formation of supported lipid bilayers containing phase-segregated domains and their interaction with gold nanoparticles

Formation of supported lipid bilayers containing phase-segregated domains and their interaction with gold nanoparticles

Putting David Craig’s Legacy to Work in Nanotechnology and Biotechnology

Building-block design

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