“…9,10 GPIs comprise a very broad array of compounds with high structural diversity due to the peculiarities of several binding clefts (the catalytic, allosteric and new allosteric, inhibitor, glycogen storage, benzimidazole, and quercetin sites) discovered so far. 11,12 Several nanomolar inhibitors with various heterocyclic scaffolds, amply discussed in review articles, 11,12 bind to the allosteric or the new allosteric sites of GP. The most populated class of GPIs is represented by glucose derivatives, which bind primarily to the catalytic site of the enzyme showing competitive inhibition.…”