New Inhibitors for Aminoglycoside-Adenylyltransferase

Saleh, Najla; Zwiefak, A.; Peczyńska‐Czoch, Wanda; Mordarski, M; Pulverer, G.

doi:10.1016/s0176-6724(88)80142-1

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Two hydroxymethyltropolones and two tropolone acetate derivatives were found to inhibit an aminoglycosideadenylyltranferase in a gentamicin-resistant Escherichia coli strain [72]. Combinations of hydroxymethyltropolones with tobramycin were more active compared with tropolone acetates against gentamicin-resistant strains displaying adenylyltransferase activity [73]. The attachment of Staphylococcus aureus to cell surfaces is an essential for infection, and -thujaplicin, a wonderful cosmetic ingredient for antifungal, antibacterial, and anti-insect activity, interferes with this step.…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

Plant Troponoids: Chemistry, Biological Activity, and Biosynthesis

Zhao

2007

CMC

102

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Tropone or tropolone and its derivatives (here together called troponoids) belong to a family of natural products with a seven-membered aromatic ring and various side groups. They are mainly synthesized by plants and fungi, and most troponoids play roles of antibacterial defenses in these organisms. With an increasingly severe situation of antibiotic resistant bacteria, as well as a requirement for antifungal medicines, troponoids have attracted extensive studies since they have powerful antibacterial and antifungal activity, particularly against antibiotic-resistant bacteria. In addition, many other biological activities such as antiviral, antitumor, antioxidant, anti-inflammatory, insecticidal, or enzyme inhibitor activities are associated with troponoids. After extensive studies in the 1960s-70s, interests in natural troponoids dedclined. However, chemical and biomedical studies on troponoids bloom again from the 1990s. To date great progress has been made with troponoid study in terms of identification of new natural troponoids, chemical synthesis and properties, biological activity, biosynthesis and metabolism. Particularly, bioassay-guided screening strategy and structure-activity relation-directed structure modification and drug design has resulted in the synthesis and discovery of many new derivatives. Many of them have great promise to be developed into new medicines for their potent and specific activities. This review presents the recent advances in troponoid studies and highlights multiple faceted biological activities of troponoids, as well as their relationships with chemical structures. Chemistry, biosynthesis, and production via biotechnology of troponoids are also briefly reviewed. Applications of troponoids in daily life, agriculture, medicine, and industry, and the related patents have been considered to further extend our understanding of the increasing impact of troponoids on humans.

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Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

Plant Troponoids: Chemistry, Biological Activity, and Biosynthesis

Zhao

2007

CMC

102

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“…The type of carbon source and its availability was shown to affect the production of bacterial antimicrobials 7 , 23 or siderophores 24 , 25 in various bacterial genera, including Pseudomonas 6 , 26 – 29 . 7-HT has been described as the P. donghuensis iron scavenger relatively recently 20 , however, the antimicrobial activities of hydroxytropolones have been known earlier 30 , 31 . It has already been established that the genes of the 7-HT biosynthesis cluster in P. donghuensis are controlled by two regulatory systems: Gac-Rsm and LysR/TetR 18 , however, the information on the nutritional regulation of these genes is lacking.…”

Section: Introductionmentioning

confidence: 99%

The carbon source-dependent pattern of antimicrobial activity and gene expression in Pseudomonas donghuensis P482

Matuszewska

Maciag

Rajewska

et al. 2021

Sci Rep

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Pseudomonas donghuensis P482 is a tomato rhizosphere isolate with the ability to inhibit growth of bacterial and fungal plant pathogens. Herein, we analysed the impact of the carbon source on the antibacterial activity of P482 and expression of the selected genes of three genomic regions in the P482 genome. These regions are involved in the synthesis of pyoverdine, 7-hydroxytropolone (7-HT) and an unknown compound (“cluster 17”) and are responsible for the antimicrobial activity of P482. We showed that the P482 mutants, defective in these regions, show variations and contrasting patterns of growth inhibition of the target pathogen under given nutritional conditions (with glucose or glycerol as a carbon source). We also selected and validated the reference genes for gene expression studies in P. donghuensis P482. Amongst ten candidate genes, we found gyrB, rpoD and mrdA the most stably expressed. Using selected reference genes in RT-qPCR, we assessed the expression of the genes of interest under minimal medium conditions with glucose or glycerol as carbon sources. Glycerol was shown to negatively affect the expression of genes necessary for 7-HT synthesis. The significance of this finding in the light of the role of nutrient (carbon) availability in biological plant protection is discussed.

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New Inhibitors for Aminoglycoside-Adenylyltransferase

Cited by 2 publications

References 21 publications

Plant Troponoids: Chemistry, Biological Activity, and Biosynthesis

Plant Troponoids: Chemistry, Biological Activity, and Biosynthesis

The carbon source-dependent pattern of antimicrobial activity and gene expression in Pseudomonas donghuensis P482

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