New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio

Oylumlu, Mustafa; Özler, Ali; Yıldız, Abdülkadir; Oylumlu, Muhammed; Acet, Halit; Polat, Nihat; Soydinç, Hatice Ender; Yüksel, Murat; Ertaş, Faruk

doi:10.3109/10641963.2013.863324

Cited by 54 publications

(52 citation statements)

References 33 publications

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“…Contrary to our study, Kurt et al, reported that NLR was not significantly different between preeclampsia and control groups, although the neutrophil count was significantly higher in the group with preeclampsia [9]. However, recently NLR has been reported to be significantly higher in preeclamptic patients in two publications supporting our results [17,18]. The ROC analysis of our study showed the NLR value of 3.08 or higher, with the sensitivity of 74.6%, specificity of 70.1% and a PLR value of 126.8 or higher, with the sensitivity of 71.8%, specificity of 72.4% to predict preeclampsia.…”

Section: Discussionsupporting

confidence: 63%

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

Gezer¹,

Ekin²,

Ertaş³

et al. 2016

Ginekol Pol

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Objectives: The aim of our study is to determine whether first-trimester neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) would be useful as new predictors of subsequent preeclampsia. Material and methods:Medical records of women with preeclampsia and healthy controls from a tertiary referral center were retrospectively evaluated. The two groups were compared in terms of clinical characteristics and first-trimester levels of hemoglobin, leukocyte, neutrophil, lymphocyte, platelet, NLR and PLR. Receiver operating characteristic curve (ROC) analysis was performed to identify the optimal NLR and PLR levels predicting preeclampsia.Results: Neutrophil (p < 0.001), platelet (p < 0.001), NLR (p < 0.001) and PLR (p < 0.001) levels were significantly elevated, whereas hemoglobin concentration (p = 0.003) was significantly lower in the group with preeclampsia as compared to the control group. On multivariate regression analysis, NLR (OR 1.43; 95% CI 1.21-1.76; p = 0.005) and PLR (OR 1.38; 95% CI 1.15-1.63; p = 0.008) were the most powerful predictive variables. The area under the ROC was 0.716 and 0.705 for NLR and PLR, respectively. The cut-off values of NLR ≥ 3.08 and PLR ≥ 126.8 predicted preeclampsia with the sensitivity of 74.6% and 71.8% and specificity of 70.1% and 72.4%, respectively. Conclusions:High NLR and PLR during the first trimester are independent predictors of subsequent preeclampsia.

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Section: Discussionsupporting

confidence: 63%

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

Gezer¹,

Ekin²,

Ertaş³

et al. 2016

Ginekol Pol

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“…Despite several reports regarding the relationship between EFT and essential hypertension, there are only three reports that investigate EFT in patients with PE. Oylumlu et al ., demonstrated a significant relationship between EFT and the presence of PE. Both the presence and severity of PE were found to be associated with increased EFT in another report by Can et al, These findings have been confirmed by a recent study conducted by Cakmak et al .…”

Section: Discussionmentioning

confidence: 97%

Assessment of epicardial fat and carotid intima media thickness in gestational hypertension

Altın

Yılmaz

Ozsoy

et al. 2018

J of Obstet and Gynaecol

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“…Therefore, EFT may play a substantial role in the pathogenesis of various CVDs. Previous studies have shown an association between EFT and EDassociated conditions such as coronary artery disease, preeclampsia, arterial stiffness, and hypertension [38][39][40]. We found that EFT is increased in BD patients compared to healthy controls.…”

Section: Discussionmentioning

confidence: 47%

Novel markers of endothelial dysfunction and inflammation in Behçet’s disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

et al. 2015

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The etiology of Behçet's disease (BD) has not been fully elucidated. However, immunological and environmental factors, endothelial dysfunction (ED), and genetic susceptibility have been proposed to play a role. In this study, we aimed to evaluate epicardial fat thickness (EFT) together with serum asymmetric dimethylarginine (ADMA), carotid intima media thickness (CIMT), and neutrophil-to-lymphocyte ratio (NLR) in BD patients with ocular involvement. Thirty-six ocular BD patients (17 active and 19 inactive ocular involvement), and 35 age and sex-matched healthy controls were enrolled to this cross-sectional study. All patients underwent examinations with transthoracic echocardiography and carotid Doppler ultrasound. Serum ADMA levels, CIMT, EFT, and NLR were compared between groups, and their association with disease activity was evaluated. Behçet's disease patients had higher WBC counts, neutrophil counts, NLR, CIMT, EFT values, and serum ADMA levels than do healthy controls. The other biochemical, hematological, and echocardiographic parameters were comparable between the two groups. Behçet's disease duration was positively correlated with EFT and CIMT. Multivariate logistic regression analysis revealed that increased serum ADMA concentration and CIMT are independently associated with BD. Neutrophil counts, NLR, and serum ADMA level were higher, and lymphocyte count was lower in patients with active ocular BD compared to those of inactive ocular BD group. Carotid intima media thickness, serum ADMA level, EFT, and NLR were increased in ocular BD patients compared to healthy subjects. In addition, both serum ADMA level and NLR were associated with disease activity of ocular involvement. Increase in disease duration was associated with increase in CIMT and EFT which suggests that anatomical changes occur in time during the disease course. Increased CIMT, serum ADMA level, EFT, and NLR may provide new clues about the role of ED and inflammation in the etiopathogenesis of BD.

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New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio

Abstract: Unlike many other inflammatory markers and bioassays, NLR and echocardiographic EFT are inexpensive and readily available biomarkers that may be useful for risk stratification in patients with pre-eclampsia.

Cited by 54 publications

References 33 publications

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia

Assessment of epicardial fat and carotid intima media thickness in gestational hypertension

Novel markers of endothelial dysfunction and inflammation in Behçet’s disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio

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