New indole–isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies

Green synthesis of 3,4‐disubstituted isoxazol‐5(4H)‐ones using ZnO@Fe3O4 core–shell nanocatalyst in water

“…Among isoxazoles, 3,4‐disubstituted isoxazol‐5(4 H )‐ones are attractive targets in both medicinal chemistry and organic synthesis . These heterocyclic systems play an important role in the field of chemotherapy and agrochemicals owing to their properties, such as antitumor, anti‐HIV, fungicidal, antiobesity, selective inhibition of protein kinase C and enzyme inhibition . Owing to the broad biological and material importance of this heterocycle, researchers have reported various methods to construct different motifs depending on the target applications.…”

2,4‐Disubstituted Phenylhydrazonopyrazolone and Isoxazolone Derivatives as Antibacterial Agents: Synthesis, Preliminary Biological Evaluation and Docking Studies

“…Isoxazole and isoxazolone derivatives have also been reported to have potent antimicrobial properties against different Gram‐positive and Gram‐negative organisms ,. They also possess many other biological activities, some of which have recently been reported by Ilangovan et al and Panathur et al . Compounds bearing the isoxazole motif are reported to be Ca 2+ Channel blockers and other isoxazole‐incorporating compounds have been reported to be selective modulators of the multidrug resistant protein…”

The synthetic and therapeutic expedition of isoxazole and its analogs

“…10) exhibited potent cytotoxicity in both lymphoma and epithelial cancer cell lines with IC 50 ranging from 3 to 7 µM. Panathur et al (2015) synthesized a new series of indole-isoxazolone hybrids bearing substituted amide, substituted [(1,2,3-triazol-4-yl)methoxy]methyl group or substituted benzylic ether at position-2 of the indole. The molecules were screened for anticancer activity against three human cancer cell lines (MDA-MB-231, MCF-7, and HT-29).…”