New implant for drainage in glaucoma. Animal trial.

Molteno, A. C. B.

doi:10.1136/bjo.53.3.161

Cited by 153 publications

(42 citation statements)

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“…Çünkü valf içermeyen diğer implantlarda erken dönemde hipotoni riski daha yüksektir 5,6,11 . Her ne kadar valfsiz tüpler üzerinde çeşitli modifikasyonlar yapılsa, tüpün sütürasyonla daraltılması gibi önlemler alınsa da valfli sistemlere göre erken hipotoni oluşma riski daha yüksektir 12,13 .…”

Section: Discussionunclassified

“…Tüp drenaj implantlarında aköz hümör tüp aracılığıyla ön kamaradan orbital dokuya direkt olarak drene olur. İlk üretilen tüp olan Molteno implantı ve Baerveldt implantları valf yapısı içerme-dikleri için persiste hipotoni bu tip tüplerin en önemli komplikasyonları olarak bildirilmiştir 5,6 . Ancak belli bir basınçta drenaj sistemini devreye sokan bir valf sistemi içeren ve böylece kontrollü GİB düşüşü sağ-layan Ahmed glokom valfi ve Krupin implantları hipotoniyi engelleyerek bu cerrahiyi daha güvenilir hâle getirmişlerdir 6,7 .…”

Section: Introductionunclassified

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Long Term Results Of Refractory Glaucoma Cases With Ahmed Glaucoma Valve Implantation

Yazgan¹,

Çelik²,

Uğurbaş³

et al. 2016

MMJ

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To evaluate long-term effects of Ahmed glaucoma valve (AGV) implantation in refractory glaucoma cases on intraocular pres Key words: Ahmed glaucoma valve, refractory glaucoma, corneal edema Öz Dirençli glokom vakalarında Ahmed glokom valf (AGV) implantasyonunun göz içi basıncı, görme keskinliği ve kornea üzerindeki uzun dönem etkilerini değerlendirmektir. 2003-2014 yılları arasında dirençli glokom tanısıyla Ahmed valf implantasyonu yapı-lan vakalar geriye dönük incelendi. Görme keskinliği en az ışık hissi düzeyinde olan ve 12 ay takip süresi olan hastalar seçildi. Ameliyat öncesi ve son muayenedeki en iyi düzeltilmiş görme keskinliği (EİDGK), göz içi basıncı (GİB), medikasyon sayısı ve merkezi kornea kalınlığı (MKK) kaydedildi. Komplikasyonlar ve uygulanan ilave cerrahiler not edildi. İlave glokom cerrahilerine gereksinim duyulmadan GİB'nın ilaçlı/ilaçsız 5-22 mmHg olması ve görme keskinliğinin korunması ve kornea saydamlığının devamlılığı tam cerrahi başarı sayıldı. Neovasküler (n=13), afakik (n=13), penetran keratoplastiye ikincil (n=7), konjenital (n=4), travmatik (n=5)ve primer dirençli glokom (n=6) olmak üzere 47 dirençli glokom vakasının 48 gözü değerlendirildi. Yaş ortalaması 50,40±22,80 yıl, takip süresi 32,33±20,[78][79][80][81][82][83][84] operasyon öncesi ve son takipteki EİDGK sırasıyla 1,50±0,61 ve 1,60±0,57 LogMAR, GİB değerleri sırasıyla 39,22±9,47 ve 17,02±4,29 mmHg, medikasyon sayısı sırasıyla 3,47±0,92 ve 1,52±1,09, MKK sırasıyla 590,00±88,86 ve 655,25±170,88 mikron saptandı (p<0,05

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Section: Discussionunclassified

Section: Introductionunclassified

Long Term Results Of Refractory Glaucoma Cases With Ahmed Glaucoma Valve Implantation

Yazgan¹,

Çelik²,

Uğurbaş³

et al. 2016

MMJ

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“…Implants loosely attached to the sclera can stimulate inflammation in the surrounding tissue (MOLTENO, 1969). Optical microscopy analysis showed mild connective tissue formation at the site of the tube suture.…”

Section: Discussionmentioning

confidence: 99%

“…It does not cause undesirable reactions to the body when used aseptically (MARASSI & FERREIRA, 2005). Tubular implants have been tested for drainage of aqueous humor in rabbits (MOLTENO, 1969) and humans (OZDAMAR et al, 2003). The choice of a Teflon catheter for making the implant of this study was due to the tubular shape that enabled to pass it through the orifice made in the sclera with the catheter needle.…”

Section: Discussionmentioning

confidence: 99%

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INTRA-OCULAR PRESSURE IN NEW ZEALAND RABBIT AFTER TEFLON TUBE IMPLANT ASSOCIATED TO MITOMYCIN C /Pressão intra-ocular após implante de tubo de teflon associado à mitomicina c em coelhos da raça Nova Zelândia

Baungarten

Eurides

Soares³

et al. 2013

Ars Vet

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SUMMARYFourteen healthy, adult New Zealand rabbits, males and females, were used to evaluate the histological and clinical aspects after the implant of Teflon tube associated to mytomicin C. The ten right eyes of group I and ten left eyes of group II were evaluated for 30 and 60 days of postoperative (PO), respectively. The other eight eyes of group III were observed for 48 hours. A bag was constituted in the bulbar conjunctive and inside of it mytomicin C was applied. A Teflon tube was introduced in the anterior chamber and fastened in the sclera, the conjunctive bag was approximated in the limbus over the implant. There was significant difference in the averages of the intraocular pressures (IOP) between the preoperative and the postoperative of 30 and 60 days. The animals of groups I and II presented hypotonia and shallow anterior chamber in the first 15 days of PO. In the histological evaluation of the conjunctive bag, descaling of the epithelium superficial cells and degeneration of the conjunctive tissue was verified, which indicated healing changes due to the action of mytomicin C. The implant of Teflon associated with mytomicin C demonstrated to be an effective method to decrease and to maintain the IOP from 30 to 60 days PO. KEY-WORDS:Antifibroblasts. Aqueous Humor. Glaucoma. Filtrative Surgery. Ophthalmology. Oryctolagus cuniculus. RESUMOForam utilizados 14 coelhos da raça Nova Zelândia, adultos, hígidos, machos e fêmeas, para avaliar os aspectos histológicos e clínicos após o implante de tubo de teflon associado a mitomicina C. Dez olhos direitos formaram o grupo I e dez olhos esquerdos formaram o grupo II avaliados por 30 e 60 dias de pós-operatório (PO), respectivamente. Os outros oito olhos formaram o grupo III observados por 48 horas. Foi constituído uma bolsa na conjuntiva bulbar e dentro dela foi aplicado mitomicina C. Um tubo de teflon foi introduzido na câmara anterior e fixado na esclera, a bolsa conjuntival foi aproximada no limbo sobre o implante. Houve diferença significativa nas médias das pressões intraoculares (PIO) entre o pré-operatório e o pós-operatório de 30 e 60 dias. Os animais dos grupos I e II apresentaram hipotonia e câmara anterior rasa nos primeiros 15 dias de PO. Na avaliação histológica da bolsa conjuntival foi verificado descamação das células superficiais do epitélio e degeneração do tecido conjuntivo, o que indicou alterações na cicatrização mediante ação da mitomicina C. O implante de teflon associado com mitomicina C demonstrou ser um método eficaz por diminuir e manter a PIO dos 30 aos 60 dias de PO.

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Comparison of Different Biomaterials for Glaucoma Drainage Devices<subtitle>Part 2</subtitle>

Ayyala¹

2000

Arch Ophthalmol

119

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Background: Inflammation associated with biomaterials may contribute to the failure of glaucoma drainage devices.Objective: To compare the inflammatory reaction associated with the insertion of Krupin silicone, Molteno polypropylene, and Acrosof end plates in the subconjunctival space of rabbits.Methods: Similar-sized glaucoma end plates made of 3 different biomaterials were sutured to the sclera in the superotemporal quadrant of the rabbit eye. Thirty eyes of 15 albino New Zealand rabbits were randomly assigned to the 3 groups. Conjunctival vascular hyperemia was graded in a masked fashion among the 3 groups. At the end of 3 weeks, the enucleated eyes were examined histologically and by scanning electron microscopy.Results: Molteno polypropylene was associated with more inflammation both in clinical observations and based on histological grading. Silicone and Acrosof were associated with less intense inflammation. One polypropylene end plate was extruded on day 21.Conclusions: Polypropylene appears to be more inflammatory than silicone. Flexible biomaterials appear to be less inflammatory than rigid ones.Clinical Relevance: Bleb failure following glaucoma drainage device implantation could be related to the biomaterial-associated inflammation. Choosing a biomaterial with the least inflammatory potential might enhance the success rate of the glaucoma drainage device.

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New implant for drainage in glaucoma. Animal trial.

Abstract: Thickness 0o75 mm. tapering to edge. Radius of curvature of undersurface 5 mm. at right angles to the limbus and 8 mm. parallel to the limbus.

Cited by 153 publications

References 4 publications

Long Term Results Of Refractory Glaucoma Cases With Ahmed Glaucoma Valve Implantation

Long Term Results Of Refractory Glaucoma Cases With Ahmed Glaucoma Valve Implantation

INTRA-OCULAR PRESSURE IN NEW ZEALAND RABBIT AFTER TEFLON TUBE IMPLANT ASSOCIATED TO MITOMYCIN C /Pressão intra-ocular após implante de tubo de teflon associado à mitomicina c em coelhos da raça Nova Zelândia

Comparison of Different Biomaterials for Glaucoma Drainage Devices<subtitle>Part 2</subtitle>

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