1997
DOI: 10.2165/00063030-199708040-00006
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New Immunosuppressive Drugs and Their Role in the Prevention of Islet Xenograft Rejection

Abstract: Islet transplantation offers an attractive future means to treat diabetes as long as prevention of xenograft rejection can be accomplished. This review analyses the role of 5 new immunosuppressive drugs [tacrolimus, sirolimus, mycophenolate mofetil, gusperimus (15-deoxyspergualin) and leflunomide] in the context of islet xenotransplantation. Although cytotoxic T cells are the major effector cells in allogeneic islet rejection, macrophages serve as important contributing effector cells in xenogeneic islet rejec… Show more

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“…The efficacy of various immunosuppressive drugs in the prevention of islet xenograft rejection (from pig-to-rat) was evaluated by a Swedish group [39]. Prednisolone 20 mg/kg/day was used in combination with CsA and cyclophosphamide.…”
Section: Discussionmentioning
confidence: 99%
“…The efficacy of various immunosuppressive drugs in the prevention of islet xenograft rejection (from pig-to-rat) was evaluated by a Swedish group [39]. Prednisolone 20 mg/kg/day was used in combination with CsA and cyclophosphamide.…”
Section: Discussionmentioning
confidence: 99%