New Imaging Parameters to Predict Sudden Cardiac Death in Chagas Disease

Moll-Bernardes, Renata; Rosado-de-Castro, Paulo Henrique; Camargo, Gabriel Cordeiro; Mendes, Fernanda Souza Nogueira Sardinha; Brito, Adriana Soares Xavier de; Sousa, Andréa Silvestre de

doi:10.3390/tropicalmed5020074

Cited by 7 publications

(12 citation statements)

References 41 publications

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“…In the early stages (B1 or B2), the echocardiogram may demonstrate alterations of LV segmental mobility ranging from hypokinesia to aneurysm formation [2,121,122]. The cardiac regions frequently affected are the basal segments of the inferior and inferolateral wall and the apex, alterations that cannot be attributed to obstructive coronary artery disease.…”

Section: Echocardiogrammentioning

confidence: 99%

“…The study of segmental mobility alterations is subjective, so the evaluation of deformation by two-dimensional speckle tracking (2DST) can become a useful tool in the early stages by identifying alterations in areas without apparent involvement [5,123]. The use of 2DST is less useful in patients with obvious segmental mobility disorders (Figure 6), but it still serves as a tool to assess the heterogeneity of systolic contraction (mechanical dispersion); these alterations are associated with ventricular arrhythmias independent of LVEF [122,124].…”

Section: Echocardiogrammentioning

confidence: 99%

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Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure

Montalvo-Ocotoxtle

Rojas‐Velasco

Rodríguez-Morales

et al. 2022

JCM

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Chagas cardiomyopathy (CC), caused by the protozoan Trypanosoma cruzi, is an important cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 to 7 million people worldwide are infected, and it is predicted that it will be responsible for 200,000 deaths by 2025. The World Health Organization (WHO) considers Chagas disease (CD) as a Neglected Tropical Disease (NTD), which must be acknowledged and detected in time, as it remains a clinical and diagnostic challenge in both endemic and non-endemic regions and at different levels of care. The literature on CC was analyzed by searching different databases (Medline, Cochrane Central, EMBASE, PubMed, Google Scholar, EBSCO) from 1968 until October 2022. Multicenter and bioinformatics trials, systematic and bibliographic reviews, international guidelines, and clinical cases were included. The reference lists of the included papers were checked. No linguistic restrictions or study designs were applied. This review is intended to address the current incidence and prevalence of CD and to identify the main pathogenic mechanisms, clinical presentation, and diagnosis of CC.

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Section: Echocardiogrammentioning

confidence: 99%

Section: Echocardiogrammentioning

confidence: 99%

Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure

Montalvo-Ocotoxtle

Rojas‐Velasco

Rodríguez-Morales

et al. 2022

JCM

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“…In this scenario, 18 F-FDG PET may be a promising tool to monitor disease activity and risk stratification of patients with CC. Future studies should address these new potential clinical applications of PET imaging 73,74 (Figure 6).…”

Section: Chagas Cardiomyopathymentioning

confidence: 99%

Autonomic Innervation Evaluation in Cardiac Disease

Brito¹,

Glavam²,

Bronchtein³

et al. 2021

International Journal of Cardiovascular Sciences

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Cardiovascular diseases are among the leading causes of mortality and morbidity in the world. In different cardiac diseases, the neuronal function of the heart is impaired. Nevertheless, the development of a simple method to assess the autonomic effects on the heart and/or autonomic dysfunction is a challenge. The evaluation of autonomic innervation in cardiac diseases has helped to improve the knowledge of the pathophysiology of these conditions, as well as to provide information on their prognosis. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are currently the only imaging methods that allow in vivo assessment of cardiac innervation. The majority of SPECT and PET radiotracers evaluate sympathetic neuronal integrity using presynaptic imaging agents that are either labeled as endogenous transmitters or analogues. Postsynaptic imaging agents have also been developed to study sympathetic neuronal integrity, as well as tracers to investigate the parasympathetic nervous system. These methods may be used to analyze the innervation of the heart and allow for early detection of abnormalities caused by, for example, ischemia, heart failure, cardiomyopathies, cardiotoxicity, and arrhythmogenic disorders. This review provides an overview of cardiac innervation evaluation and their application in the assessment of heart disease. Autonomic Nervous SystemThe autonomic nervous system (ANS) is broad and extends to most organic systems. Therefore, the study of

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“…27 The close relationship of MF, ventricular arrhythmias, and sudden cardiac death has been described by several studies on ischemic and nonischemic cardiomyopathies. [28][29][30][31][32] Distinguishing different patterns of MF and determining its extent by LGE-CMR provides important information that allows physicians to distinguish the etiology of cardiomyopathies and improve prognosis scores. White et al, 33 demonstrated that the etiology of aborted sudden cardiac death or sustained monomorphic ventricular tachycardia was changed in 50% of the cases where patients were evaluated by CMR in comparison to conventional diagnostic investigation with transthoracic echocardiography and coronary angiography.…”

Section: Cmr As a Risk Stratification Toolmentioning

confidence: 99%