New imaging markers for preconceptional and first-trimester utero-placental vascularization

Reijnders, Igna F.; Mulders, A.; Koster, Maria P. H.; Koning, Anton H. J.; Frudiger, A.; Willemsen, Sten P.; Jauniaux, E; Burton, Graham J.; Steegers‐Theunissen, R.P.M.; Steegers, Eric A.P.

doi:10.1016/j.placenta.2017.11.013

Cited by 21 publications

(44 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A newly developed technique is Virtual Reality (VR) which can be combined with measurements of 3D power Doppler (PD) ultrasound volumes and visualizes the placental circulation from early pregnancy onward, in three dimensions with depth perception. As previously demonstrated by Reijnders et al (2018) this technique is feasible and reliable for use in the first trimester of pregnancy to measure placental parameters, that reflect PV and uteroplacental vascularization of the uterine/maternal side (i.e., the placental bed).…”

Section: Introductionmentioning

confidence: 85%

“…To minimize artifacts and measurement errors by movement, participants were asked to hold their breath for approximately 30 s during image acquisition. All ultrasound examinations were performed according to international guidelines on safe use of Doppler ultrasound in the first trimester of pregnancy (ALARA-principle) and, as such, total scanning time was kept as low as possible with a maximal duration of 30 min and a maximal thermal index of 1.3 (The British Medical Ultrasound Society, 2009;Bhide et al, 2013;World Federation For Ultrasound in Medicine and Biology, 2013;Reijnders et al, 2018).…”

Section: Ultrasoundmentioning

confidence: 99%

“…Currently it is not possible to distinct between the maternal blood space and embryonic vasculature within the uPVV. A more detailed description and validation of the methods for uPVV measurements has previously been published (Reijnders et al, 2018). After VOCAL and VR measurements, uPVV was divided by PV to calculate a placental vascular volume ratio (uPVV/PV ratio).…”

Section: Offline 3d Measurementsmentioning

confidence: 99%

See 2 more Smart Citations

Larger First-Trimester Placental Volumetric Parameters Are Associated With Lower Pressure and More Flow-Mediated Vasodilation of the Fetoplacental Vasculature After Delivery

et al. 2020

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 85%

Section: Ultrasoundmentioning

confidence: 99%

Section: Offline 3d Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Larger First-Trimester Placental Volumetric Parameters Are Associated With Lower Pressure and More Flow-Mediated Vasodilation of the Fetoplacental Vasculature After Delivery

et al. 2020

View full text Add to dashboard Cite

“…By assessing these 3D datasets in an innovative virtual reality system (Barco I-Space or 3D desktop), depth perception and three-dimensional interaction enables more accurate and detailed quantification of the utero(placental) vascular volumes. At the Erasmus MC, there is extensive experience with this novel technology and the uteroplacental vascular volume measurements have proven to be feasible and reliable 45 46…”

Section: Study Procedures/measurementsmentioning

confidence: 99%

Study protocol for a prospective cohort study to investigate Hemodynamic Adaptation to Pregnancy and Placenta-related Outcome: the HAPPO study

et al. 2019

View full text Add to dashboard Cite

IntroductionThe importance of cardiovascular health in relation to pregnancy outcome is increasingly acknowledged. Women who develop certain pregnancy complications, in particular preeclampsia, are at higher risk for future cardiovascular disease. Independent of its outcome, pregnancy requires a substantial adaptive response of the maternal cardiovascular system. In the Hemodynamic Adaptation to Pregnancy and Placenta-related Outcome (HAPPO) study, we aim to examine longitudinal maternal haemodynamic adaptation to pregnancy from the preconception period onwards. We hypothesise that women who will develop adverse pregnancy outcomes have impaired cardiovascular health before conception, leading to haemodynamic maladaptation to pregnancy and diminished uteroplacental vascular development.Methods and analysisIn this prospective cohort study embedded in the Rotterdam periconception cohort, 200 women with a history of placenta-related pregnancy complications (high-risk group) and 100 women with an uncomplicated obstetric history (low-risk group) will be included. At five moments (preconception, first, second and third trimester and postdelivery), women will undergo an extensive examination of the macrocirculatory and microcirculatory system and uteroplacental vascular development. The main outcome measures are differences in maternal haemodynamic adaptation to pregnancy between women with and without placenta-related pregnancy complications. In a multivariate linear mixed model, the relationship between maternal haemodynamic adaptive parameters, (utero)placental vascularisation indices and clinical outcomes (occurrence of pregnancy complications, embryonic and fetal growth trajectories, miscarriage rate, gestational age at delivery, birth weight) will be studied. Subgroup analysis will be performed to study baseline and trajectory differences between high-risk and low-risk women, independent of subsequent pregnancy outcome.Ethics and disseminationThis study protocol was approved by the Medical Ethics Committee of the Erasmus MC, Rotterdam, the Netherlands (MEC 2018–150). Results will be disseminated to the medical community by publications in peer-reviewed journals and presentations at scientific congresses. Also, patient associations will be informed and the public will be informed by dissemination through (social) media.Trial registration numberNL7394 (www.trialregister.nl)

show abstract

“…12 A high intraobserver and interobserver reproducibility and its potential interest for placental function study were reported by our team. [13][14][15] The main limit of this technique is that the calculated 3DPD indices are dependent on different physiological parameters (such as body mass index (BMI), placenta location) and machine settings. This has been proved in vitro, and it is also considered as a main cause of heterogeneous previously published data.…”

mentioning

confidence: 99%

First trimester screening for pre-eclampsia and intrauterine growth restriction using three-dimensional Doppler angiography (SPIRIT): protocol for a multicentre prospective study in nulliparous pregnant women

et al. 2020

View full text Add to dashboard Cite

IntroductionPre-eclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to chronic uteroplacental hypoperfusion. Nowadays, there is no screening or diagnostic test for uteroplacental vascularisation deficiency in pregnant women. Since 2004, 3 three-imensional power Doppler (3DPD) angiography has been used for the evaluation of uteroplacental vascularisation and three vascular indices are usually calculated: Vascularisation Index (VI), Flow Index (FI) and vascularisation-FI (VFI). A high intraobserver and interobserver reproducibility and a potential interest for placental function study were reported by our team and others.The main objective of our study is to determine differences in 3DPD indices at first trimester between pregnancies defined at their outcome as uncomplicated pregnancy, PE (mild and severe) and IUGR in nulliparous women.Methods and analysisThis is a national multicentre prospective cohort study conducted in four French maternity units. We expect to include 2200 women in a period of 36 months. The nulliparous pregnant women will be recruited during their first trimester consultation (11–13+6 gestation week (GW)).The 3DPD and uterine artery Doppler acquisition will be included in the current routine 11–13+6 GW ultrasound. Also, additional blood samples will be taken for biomarker analysis (PAPP-A and P1GF) and biological collection. Uteroplacental VIs (FI and VFI) will be measured. For each subgroup (uncomplicated pregnancy, PE and IUGR), mean values in 3DPD indices will be computed and compared using a pairwise t test with a Bonferroni correction p value adjustment.Ethics and disseminationThe study was approved by the French Ethics Committee, the Comité de Protection des Personnes SUD MEDITERRANEE IV on 13 February 2018 with reference number 17 12 03. The results of this study will be published in a peer-reviewed journal and will be presented at relevant conferences.Trial registration numberNCT03342014; Pre-results. PHRCN-16-0567.

show abstract

New imaging markers for preconceptional and first-trimester utero-placental vascularization

Cited by 21 publications

References 24 publications

Larger First-Trimester Placental Volumetric Parameters Are Associated With Lower Pressure and More Flow-Mediated Vasodilation of the Fetoplacental Vasculature After Delivery

Larger First-Trimester Placental Volumetric Parameters Are Associated With Lower Pressure and More Flow-Mediated Vasodilation of the Fetoplacental Vasculature After Delivery

Study protocol for a prospective cohort study to investigate Hemodynamic Adaptation to Pregnancy and Placenta-related Outcome: the HAPPO study

First trimester screening for pre-eclampsia and intrauterine growth restriction using three-dimensional Doppler angiography (SPIRIT): protocol for a multicentre prospective study in nulliparous pregnant women

Contact Info

Product

Resources

About