New hydrogels based on carbohydrate and on carbohydrate-synthetic polymer networks

Crescenzi, V.; Paradossi, Gaio; Desideri, P.; Dentini, Mariella; Cavalieri, Francesca; Amici, E.; Lisi, R. De

doi:10.1016/s0966-7822(96)00051-2

Cited by 51 publications

(22 citation statements)

References 5 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Materials with these properties are extensively used for the design of systems with controllable release of drugs in pharmacology, for the creation of constructions with definite chemomechanical properties, etc. 107,127,133 Wang et al 126 obtained PEC by mixing equimolar amounts of an acetic-acid solution of chitosan (300 kDa, DD 86%) with aqueous solution of PAA (230 kDa). After covalent cross-linking with glutaraldehyde, pH-sensitive membranes were obtained from PEC.…”

Section: Polyelectrolyte Complexes Of Chitosan With Synthetic Polmentioning

confidence: 99%

Polyelectrolyte complexes of chitosan: formation, properties and applications

Krayukhina¹,

Самойлова²,

Yamskov³

2008

Russ. Chem. Rev.

View full text Add to dashboard Cite

The results of studies of polyelectrolyte complexes The results of studies of polyelectrolyte complexes of chitosan are summarised and described systematically. of chitosan are summarised and described systematically. Chitosan complexes with biopolyelectrolytes, with modified Chitosan complexes with biopolyelectrolytes, with modified natural polyelectrolytes and with synthetic polyanions natural polyelectrolytes and with synthetic polyanions are considered. Medical and biotechnological applications are considered. Medical and biotechnological applications of chitosan complexes are discussed. The bibliography of chitosan complexes are discussed. The bibliography includes 156 references includes 156 references. .

show abstract

Section: Polyelectrolyte Complexes Of Chitosan With Synthetic Polmentioning

confidence: 99%

Polyelectrolyte complexes of chitosan: formation, properties and applications

Krayukhina¹,

Самойлова²,

Yamskov³

2008

Russ. Chem. Rev.

View full text Add to dashboard Cite

show abstract

“…us, the nature of highly pH-sensitive swelling brings PEC to the application of oral drug delivery [7,8] because the pH varies at each organs or the diseased part of human body. Due to the consideration of biocompatible and nontoxic substance as the components of polyelectrolyte complexes in such applications, several chitosan-based PEC have been studied for controlled release formulations in combination with either synthetic or natural polyanions, such as alginate [9], polyacrylic acid [10], carboxymethyl-cellulose [11], dextran sulfate [12], xanthan [13], and collagen [14]. One of the natural polyanions under investigation is -carrageeenan, an acidic polysaccharide with sulfate groups [15].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Carrageenan Polyelectrolyte Complex for the Delivery of Protein Drugs

Hein

Wang

2013

ISRN Biomaterials

View full text Add to dashboard Cite

A chitosan-carrageenan polyelectrolyte complex (PEC) was prepared by salt induced impeding of polyplex formation method and was encapsulated with bovine serum albumin (BSA) to study the potential to be tailored to the pH responsive oral delivery of protein drugs. e FTIR spectra showed the successful formation of the PEC under the experimental condition. e release kinetics of BSA from the PEC was studied in the simulated gastrointestinal �uids with and without digestive enzymes. e prepared PEC showed the nature of pH-sensitivity. A typical controlled release of BSA from the PEC (180 g of BSA from 3 mg of PEC) was obtained in the simulated intestinal �uid (SIF, pH 7.5), which was due to the signi�cant swelling and disintegration of PEC, but little amount of BSA was released (11 g of BSA from 3 mg of PEC) in the simulated gastric �uid (SGF, pH 1.2), con�rming acidic stability of the prepared PEC. e presence of digestive enzymes was found not to affect the response of PEC to ambient pH value, but to speed up the release of BSA from carriers.

show abstract

“…7 Particularly important is the use of the dialdehydes as cross-linking agents for polymers such as proteins, 8 polysaccharides, 9 and other functionalized macromolecular compounds. 10 However, only in particular cases this method appears capable to give acceptable results.…”

Section: Introductionmentioning

confidence: 99%