New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study

El-Miligy, Mostafa M.M.; Hazzaa, A. A. B.; El-Messmary, Hanan; Nassra, Rasha A.; El-Hawash, Soad A.M.

doi:10.1016/j.bioorg.2017.03.012

Cited by 53 publications

(28 citation statements)

References 38 publications

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“…Besides, new molecules containing rhodanine and benzofuran scaffolds were designed, synthesized, and reported to exhibit dual COX-2, and 5-LOX inhibitory potential [ 39 , 40 ]. A recent patent survey reported a review focused on benzofuran inhibitors [ 41 , 42 ].…”

Section: Anti-inflammatory Drugsmentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

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Section: Anti-inflammatory Drugsmentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

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“…Benzothiophene, takes its origin from the Coffee beans ( Spiller, 1998 ), is one of the aromatic molecules with benzene and five member heterocyclic sulphur-containing rings. Thank to the broad domain of medicinal activities of this family, the benzothiophene derivatives have attracted the attention of many research groups ( Ramos et al, 2016 ; Amr et al, 2010a ; El-Miligy et al, 2017 ). It finds applications in agrochemical and pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Design, molecular docking analysis of an anti-inflammatory drug, computational analysis and intermolecular interactions energy studies of 1-benzothiophene-2-carboxylic acid

Sagaama

Issaoui

2020

Computational Biology and Chemistry

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“…The interaction with COX-2 receptor was also supported by molecular docking studies. 48 The synthesis and analgesic and antiinflammatory activity of diphenyl thiazole and thiazolidine-4-one were reported. Thiazolidine-4-one was further attached with unsubstituted and substituted benzylidene.…”

Section: Thiazole Benzothiazole and Benzothiophene Containing Hybridsmentioning

confidence: 99%

Hybrid organic molecules as antiinflammatory agents; a review of structural features and biological activity

Mohsin¹,

Ahmad²

2018

Turk J Chem

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Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of pain and inflammation.Some undesirable effects are linked with NSAIDs such as the gastrointestinal tract (GIT) toxicity and cardiovascular disturbances. At present the preparation of a hybrid molecular technique is being used to produce new analgesic and antiinflammatory molecules. Attachment of NSAIDs with nitric oxide and hydrogen sulfide releasing molecules produced some gastroprotective agents with improved analgesic and antiinflammatory activities. Combination of NSAIDs with different biologically active 5-membered, 6-membered, and condensed heterocyclic rings has also led to the formation of some potent molecules. Some of these hybrid molecules, e.g., ibuprofen-thiazole, exhibited less GIT toxicity, while others showed selectivity for COX-2 enzyme, e.g., quinazolinone-pyrimidine and benzothiophene-rhodanine hybrids. COX-2 selectivity was also exhibited by hybrids of NSAIDs with natural molecules such as salicylates-resveratrol, chromoneoxindole, and chrysin-indole-pyrazole. The preparation of new hybrid molecules is significant because they can serve as a lead compound for the discovery and development of safer analgesic and antiinflammatory agents.

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New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study

Cited by 53 publications

References 38 publications

Plants as Sources of Anti-Inflammatory Agents

Plants as Sources of Anti-Inflammatory Agents

Design, molecular docking analysis of an anti-inflammatory drug, computational analysis and intermolecular interactions energy studies of 1-benzothiophene-2-carboxylic acid

Hybrid organic molecules as antiinflammatory agents; a review of structural features and biological activity

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